We delve deep into Alzheimer's disease (AD) research, focusing on the impact of the gut microbiome on AD development, as well as the interactions between neuropsychiatric symptoms and AD pathology.
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Assistant Professor
Department of Neuroscience and Regenerative Medicine
The Medical College of Georgia at Augusta University
Former Research Assistants associated with previous institutions/labs (selected in the USA)
Ben B. (2019, graduate), MD/PHD Program, a lab rotation, Current: WU-MD program.
Laura M. (2015-2018, undergraduate), Amgen Scholar, Current: Resident at Emory.
Bryan S. (2010, undergraduate), IE-Pre Grad internship, Current: MIT.
Publications (Selected first-authorship Journal Articles; Google Scholar: https://t.co/AwmLP59fI8)
#corresponding author; *equal contribution with first author
Seo DO#, Holtzman DM. (2024). Current understanding of Alzheimer’s disease-associated microbiome and therapeutic strategy. Experimental & Molecular Medicine. 56, 86–94 (2024).
Seo DO, O'Donnell D, Jain N, Ulrich JD, Herz J, Li Y, Lemieux M, Cheng J, Hu H, Serrano JR, Bao X, Franke E, Karlsson M, MeierM, Deng S, Desai C, Dodiya H, Lelwala-Guruge J, Handley SA, Kipnis J, Sisodia SS, Gordon JI, Holtzman DM. (2023). ApoE isoform and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science, 379, 6628.
Highlighted by Science and Nature
Commentaries: by Jain & Li (Science), Martín-Peña & Tansey (Nature), Kazmi & Hsiao (Cell), Yates (Nature Review Neuroscience).
Seo DO*, Zhang ET*, Piantadosi SC, Marcus DJ, Motard LE, Kan BK, Gomez AM, Nguyen TK, Xia Li, Bruchas MR. (2021). Locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing. Neuron,109(13):2116-2130.
Seo DO, Holtzman DM. (2020). Gut microbiota: from the forgotten organ to a potential key player in the pathology of Alzheimer disease. The Journals of Gerontology: Series A,75(7):1232-1241.
Seo DO, Boros BD, & Holtzman DM. (2019). The microbiome: A target for Alzheimer disease. Cell Research, 29, 779–780.
Seo DO, Motard LE, Bruchas MR. (2019). Contemporary strategies for dissecting the neuronal basis of neurodevelopmental disorders., Neurobiology of Learning and Memory, 165, 106835.
Roquet RF*, Seo DO*, Jones CE, Monfils MH. (2018). Differential effects of predictable vs. un-predictable aversive experience early in development on fear memory and learning in adulthood. Behavioral Neuroscience, 132(1), 57-65.
Seo DO, Bruchas MR. (2017). Polymorphic computation in locus coeruleus networks. Nature Neuroscience, 20: 1517-1519.
Seo DO*, Funderburk SC*, Bhatti DL, Motard LE, Newbold D, Girven KS, McCall JG, Krashes MJ, Sparta, DR, Bruchas MR (2016). Centromedial nuclei of the amygdala GABAergic projections to ventromedial prefrontal cortex modulate reward behavior, Journal of Neuroscience, 36(42):10831-10842.
Seo DO, Carillo MA, Chih-Hsiung Lim, S, Tanaka KF, Drew MR (2015). Adult Hippocampal Neurogenesis Modulates Fear Learning through Associative and Nonassociative Mechanisms. Journal of Neuroscience, 35(32), 11330-11345.
Seo DO, Pang MH, Shin MS, Kim HT, Choi JS. (2008). Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats. Behavioral Brain Research, 192(2), 264-268.
Seo DO, Lee YK, Choi JS. (2006). Making of fear: a systematic dissection of Pavlovian fear conditioning. The Korean Journal of Experimental Psychology, 18: 1-19.
Book Chapter
Seo DO, Monfils MH. (2012). Linking fear learning to memory consolidation, Seel, N.M.(ed.), Encyclopedia of the Sciences of Learning, Springer Science+Business Media, Berlin, Germany.
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