Towards the end of a race, a masked driver nicknamed Frankenstein is nearing the finish line, pursued by his rival Machine Gun Joe. His navigator, Case, reports that all of his defensive weapons have malfunctioned. Against her protests, Frankenstein refuses to let Joe finish first. Case ejects herself out of the car just before Joe destroys it as it crosses the finish line.

Six months later, Jensen is transferred to Terminal Island Prison. Hennessey's second in-command Ulrich calls Jensen to her office. She tells him that Frankenstein had died from the injuries he received at the end of the previous race, and offers to let Jensen go free if he drives Frankenstein's car to win one more race. Jensen accepts the offer and meets Frankenstein's maintenance crew consisting of Coach, Gunner, and Lists; they explain to Jensen that Hennessey wants him to become Frankenstein to rebuild the profits and audience of "Death Race", which has halved since Frankenstein's "disappearance".




The Death Race