Welcome to Han Lab 

Dr. Han's research group within the Department of Biological Sciences at the University of North Texas, Denton, develops predictive multiscale simulators to investigate the molecular mechanisms underlying autonomic control of the heart. By integrating molecular dynamics (MD) and enhanced sampling simulations, the lab deciphers how neurotransmitters like norepinephrine interact with β1- and β2-adrenergic receptors, revealing how these interactions regulate myocardial electrical activity. The team’s models capture key conformational changes and binding events that inform functional kinetic models of cardiac stimulation, advancing our understanding of arrhythmogenic processes.

In addition to cardiovascular modeling, the Han Lab focuses on protein and peptide design for therapeutic applications. This includes the previously engineered peptides, inspired by natural toxins, to selectively target ion channels like Nav1.7 for pain therapy. The lab also explores the antimicrobial potential of designed peptides as next-generation antibiotics.

By bridging molecular insights with functional outcomes, the Han Lab aims to drive innovations in precision cardiovascular medicine and therapeutic peptide design.