Taehee Han
Citizenship: South Korea
E-mail: th3138@cumc.columbia.edu
Hi!
I am Taehee Han, born in Seoul. I attended the Korea Science Academy (KSA) of KAIST in 2010.
I earned my bachelor's degree in Chemical and Biomolecular Engineering from KAIST and then went on to get my Master's and Ph.D. degree in the same department.
I conducted my research on metabolic engineering, synthetic biology, and microbiology in the Metabolic & Biomolecular Engineering Laboratory (MBEL) at KAIST under the guidance of Professor Sang Yup Lee (Google scholar, lab). Currently, I am working as a postdoctoral fellow at Columbia University (lab) and I am always eager to explore any research opportunities!
Education
Korea Science Academy of KAIST, Busan, Korea (2010.02~2013.02)
Minnesota Institute of Talented Youth Summer camp, Minnesota, United States (2011.07)
KAIST (Korea Advanced Institute of Science and Technology), Daejeon, Korea
- B.S. Chemical and biomolecular engineering, (2013.03~2017.02)
- M.S. Chemical and biomolecular engineering, (2017.03~2019.02)
- Ph.D. Chemical and biomolecular engineering, (2019.03~2023.02)
Research experiences
Research on developing solar cell at Pusan National University, Busan, Korea (2011.02~2011.08)
Research course at Korea Science Academy of KAIST, Busan, Korea (2012.07~2012.12)
Individual research at Metabolic and Biomolecular Engineering Laboratory(MBEL), KAIST, Korea (2013.09~2014.01, 2016.03~2016.08)
Postdoctoral researcher at Bioprocess Engineering Center, KAIST, Korea (2023.03~ 2024.03)
Postdoctoral Fellow, Columbia University Irving Medical Center, New York, United States (2024.04~)
Research Interests
Biotechnology
Metabolic engineering
Synthetic biology
Protein/Enzyme engineering
Microbiology
Systems biology
Publications (Google scholar)
*: corresponding author
Chang, M. J., Ahn, S. J., Han, T.*, and Yang, D., "Gene expression modulation tools for bacterial synthetic biology", Biotechnology for Sustainable Materials, accepted (2024)
Han, T., Nazarbekov, A., Zou, X., Lee, S.Y., “Recent advances in systems metabolic engineering”, Curr. Opin. Biotechnol., 84:103004 (2023)
Han, T., Choi, K.R., Choi, S.Y., Chae, T. U., Lee, S.Y., “Synthetic Biology: Past, Present, and Future”, The National Academy of Sciences, Republic of Korea (2023) link
Han, T. and Lee, S.Y. "Metabolic engineering of Corynebacterium glutamicum for the production of valerolactam, a nylon-5 monomer", Metab. Eng., 79: 78-85 (2023)
Cho, J.S., Yang, D., Prabowo, C.P.S., Ghiffary, M.R., Han, T., Choi, K.R., Moon, C.W., Zhou, H., Ryu, J.Y., Kim, H.U., Lee, S.Y., “Targeted and high-throughput gene knockdown in diverse bacteria using synthetic sRNAs”, Nat. Commun., 14: 2359 (2023)
Luo, Z.W., Ahn, J.H., Chae, T.U., Choi, S.Y., Park, S.Y., Choi, Y., Kim, J., Prabowo, C.P.S., Lee, J.A., Yang, D., Han, T., Xu, H., Lee, S.Y., "Metabolic Engineering: Concepts and Applications, Volume 13a - Chapter 11 – Metabolic Engineering of Escherichia coli", Nielsen, J., Stephanopoulos, G. and Lee, S.Y. (series eds.), WILEY-VCH, Weinheim, Germany (2021)
Han, T., Kim, G.B., and Lee, S.Y. "Glutaric acid production by systems metabolic engineering of an L-lysine–overproducing Corynebacterium glutamicum", Proc. Natl. Acad. Sci. (PNAS), 117(48): 30328-30334 (2020)
Ko, Y.-S., Kim, J.W., Lee, J.A., Han, T., Kim, G.B., Park, J.E. and Lee, S.Y., "Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production", Chem. Soc. Rev., 49: 4615-4636 (2020)
Cho, J.S., Gu, C., Han, T., Ryu, J.Y., and Lee, S.Y., "Reconstruction of context-specific genome-scale metabolic models using multiomics data to study metabolic rewiring", Curr. Opin. Sys. Biol., 15: 1-11 (2019)
Patents
Lee, S.Y., Cho, J.S., Kim, J.W., Ko, Y.S., Prabowo, C.P.S., Han, T., "Variant Microorganism Producing 1,3-propanediol and Method for Preparing 1,3-propanediol Using thereof" Korean patent: appl 10-2018-0005451. Registered 10-2103408-0000
PCT patent: PCT/KR2019/000571
US patent: 16962213
JP patent: 2020-540381
EP patent: 19740842.0
CN patent: 201980016833.8
Lee, S.Y., Cho, J.S., Kim, J.W., Ko, Y.S., Prabowo, C.P.S, Han, T., “Recombinant Corynebacterium Producing 1,3-PDO and Inhibited 3-HP Production and Method for Preparing 1,3-PDO Using Thereof" Korean patent: appl 10-2018-0058952. Registered 10-2201720
PCT patent: appl PCR/KR2019/004961
US patent: 17055971
CN patent: 201980044658.3
JP patent: 2020-565891
EP patent: 19808016.0
Lee, S.Y., Han, T., “Recombinant Microorganism Introduced Glutaric Acid Transporter Gene and Method for Preparing Glutaric Acid Using the Same” Korean patent: appl 10-2020-0183087
US patent: 17549757
DE patent: 2021 134 081.0
CN patent: 202111587989.7
Academic Activities
Journal Reviewer
Early Career Reviewer Board of BioMedCentral (BMC), part of Springer Nature
- Biotechnology for Sustainable Materials
- Biotechnology for the Environment
- Blue Biotechnology
Peer-review
Journal, Biotechnology and Bioprocess Engineering (2023)
Journal, Microbial Cell Factories (2023)
Awards & Honors
The National Scholarship for Science and Engineering, Korea Student Aid Foundation (KOSAF), ~$5,300/year (2013~2017)
Young researcher grant, Metabolic engineering 12, Munich, Germany, $700 (2018)
Selected as the member of 한국을 빛내는 사람들(한빛사) link
KAIST News link
BRIC Bio TOP 5 research (2020) link
KAIST breakthrough research (2021) link
Top prize at PONY Chung Essay competition 포니정 에세이 공모전 최우수상 (2021) link
Best poster presentation award in KSBB Spring meeting and International Symposium (2022) link link
Best oral presentation award in KAIST Dpt. Chemical&Biomolecular Engineering Graduate Symposium, $97 (2022) link
Registration Support, Metabolic engineering 15, Marina Bay Sands, Singapore, $400 (2023)
KAIST breakthrough research (2023) link
Presentations
Oral presentations/Seminars
Han, T., "Systems metabolic engineering for the production of monomers for polymer synthesis", Synthetic Biology Young Speaker Series (SynBYSS), March 14, 2024
Han, T., Lee, S.Y., “High-level Production of Valerolactam, a Nylon 5-monomer, by Metabolic Engineering of Corynebacterium glutamicum” 2023 KSBB Fall Meeting and International Symposium, BEXCO, Busan, Korea, 4-6 October 2023
Han, T., Lee, S.Y., “Metabolic Engineering of Corynebacterium glutamicum for the Production of Valerolactam, a Nylon 5-Monomer” KMB 50th Anniversary 2023 Annual Meeting & International Symposium, HICO, Gyeongju, Korea, 21-23 June 2023
Han, T., Lee, S.Y., “Glutaric acid Production by Systems Metabolic Engineering of Corynebacterium glutamicum”, KAIST Dpt. Chemical & Biomolecular Engineering Graduate Symposium, KAIST, Daejeon, Korea, 27 May 2022
Han, T., Shin, J., Cho, J., Lee, S. Y., “Corynebacterium glutamicum as a Biofactory for Large-scale Production of Glutaric acid”, 2019 KIChE Spring Meeting and International Symposium, The Korean Institute of Chemical Engineers, ICC Jeju, Jeju, Korea, 24-26 April 2019
Han, T., Lee, S.Y., “Metabolic Engineering of Corynebacterium glutamicum for production of glutaric acid”, Metabolic Engineering 2018, Munich, Germany, 24-28 June 2018
Poster presentations
Han, T., Lee, S.Y., “Sustainable production of glutaric acid by systems metabolic engineering of L-lysine overproducing Corynebacterium glutamicum” 2023 KSBB Fall Meeting and International Symposium, BEXCO, Busan, Korea, 4-6 October 2023
Han, T., Lee, S.Y., “Metabolic Engineering of Corynebacterium glutamicum for the Production of Valerolactam, a Nylon 5-Monomer”, KMB 50th Anniversary 2023 Annual Meeting & International Symposium, HICO, Gyeongju, Korea, 21-23 June 2023
Han, T., Kim, G.B., Lee, S.Y., “Systems metabolic engineering of an L-lysine overproducing Corynebacterium glutamicum strain for the production of glutaric acid”, KMB 50th Anniversary 2023 Annual Meeting & International Symposium, HICO, Gyeongju, Korea, 21-23 June 2023
Han, T., Kim, G.B., Lee, S.Y., “Systems metabolic engineering of Corynebacterium glutamicum for the production of glutaric acid”, Metabolic Engineering 15, Marina Bay Sands, Singapore, 11-15 June 2023
Han, T., Lee, S.Y., “Microbial production of nylon-5 monomer valerolactam by metabolic engineering of Corynebacterium glutamicum”, Metabolic Engineering 15, Marina Bay Sands, Singapore, 11-15 June 2023
Han, T., Kim, G.B., Lee, S.Y., “Systems metabolic engineering of Corynebacterium glutamicum for the production of glutaric acid”, 2023 KSBB Spring Meeting and International Symposium, ICC Jeju, Korea, 12-14 April 2023
Park, S.Y., Binkely, R.M., Lee, M.H., Eun, H., Han, T., Lee, S.Y., “Enhanced astaxanthin production by metabolic engineering of Escherichia coli”, 2023 KSBB Spring Meeting and International Symposium, ICC Jeju, Korea, 12-14 April 2023
Han, T., Bang, J., Hwang, C. H., Ahn, J. H., Lee, J. A., Lee, S. Y., “Development of an Engineered Escherichia coli Strain Grows on CO2 and Formic Acid”, 2022 KSBB Fall Meeting and International Symposium, Advanced Biotechnology for Bioindustry 4.0, Jeju Shinhwa world, Jeju, Korea, 28 - 30 September, 2022
Han, T., Cho, J. S., Choi, K. R., Prabowo, C.P.S., Shin, J. H., Yang, D., Jang, J., Lee, S. Y., “Development of CRISPR-assisted Genome Engineering for Corynebacterium glutamicum”, 2022 KSBB Fall Meeting and International Symposium, Advanced Biotechnology for Bioindustry 4.0, Jeju Shinhwa world, Jeju, Korea, 28 - 30 September, 2022
Han, T., Ahn, J. H., Seo, H., Park, W., Seok, J., Lee, J. A., Kim, W. J., Kim, G. B., Kim, K.-J., Lee, S. Y., “Utilization of Optimal Malate Dehydrogenase for Enhanced Succinic Acid Production by Mannheimia succiniciproducens”, 2022 KSBB Fall Meeting and International Symposium, Advanced Biotechnology for Bioindustry 4.0, Jeju Shinhwa world, Jeju, Korea, 28 - 30 September, 2022
Han, T., Kim, G. B., Lee, S. Y, “Glutaric acid production by systems metabolic rngineering of Corynebacterium glutamicum”, 2022 KSBB Spring Meeting and International Symposium, Advanced Biotechnology for Human Society, DCC, Daejeon, Korea, 13-15 April 2022
Han, T., Shin, J. H., Park, S. H., Oh, Y. H., Choi, J. W., Lee, S. Y., “Microbial production of 5-aminovaleric acid using Corynebacterium glutamicum as a platform strain”, 2022 KSBB Spring Meeting and International Symposium, Advanced Biotechnology for Human Society, DCC, Daejeon, Korea, 13-15 April 2022
Shin, J. H., Park, S. H., Oh, Y. H., Choi, J. W., Han, T., Lee, S. Y., “Corynebacterium glutamicum as a Biofactory for 5-Aminovaleric acid Production”, 2020 KSBB Spring Meeting and International Symposium: e-conference, 25-26 June 2020
Luo, Z. W., Cho, J. S., Han, T., Lee, S. Y., “Production of Methyl-anthranilate, a Grape Flavor Compound by Metabolically Engineered Microbes”, 2020 KSBB Spring Meeting and International Symposium: e-conference, 25-26 June 2020
Han, T., Shin, J.H., Park, S.K., Oh, Y.H., Choi, J.W., Lee, S.Y., “Corynebacterium glutamicum as a biofactory for 5-aminovaleric acid production”, Metabolic Engineering Summit 2019, Tianjin, China, 20-22 October, 2019
Han, T., Park, S.H., Lee, S.Y., “Enhanced production of cadaverine by metabolically engineered Corynebacterium glutamicum”, Metabolic Engineering Summit 2019, Tianjin, China, 20-22 October,2019
Han, T., Yang, J. E., Kim, J. W., Oh Y. H., Choi, S. Y., Park, S. J., Lee, S. Y., “Production of poly(2-hydroxyisovalerate-co-lactate) through engineered Escherichia coli”, Metabolic Engineering Summit 2019, Tianjin, China, October 20-22,2019
Han, T., Shin, J. H., Cho, J. S., Lee, S. Y., “Production of 5-Aminovaleric acid from metabolically engineered Corynebacterium glutamicum”, 2019 KIChE Spring Meeting and International Symposium, The Korean Institute of Chemical Engineers, ICC Jeju, Jeju, Korea, 24-26 April, 2019
Han, T., Shin, J., Cho, J., Lee, M., Lee, S. Y., “Metabolic Engineering of Corynebacterium glutamicum for Enhanced Production of 5-Aminovaleric acid”, 2018 KSBB International Academia-Industry Joint Meeting, The Korean Society for Biotechnology and Bioengineering, Sejong University Convention Center, Seoul, 10-12 October 2018
Han, T., Kim, S., Lee, J., Lee, S. Y., “Metabolic Engineering of Corynebacterium glutamicum for Enhanced Production of L-ornithine”, 2018 KSBB International Academia-Industry Joint Meeting, The Korean Society for Biotechnology and Bioengineering, Sejong University Convention Center, Seoul, 10-12 October 2018
Han, T., Park, S., Kim, H. U., Kim, T., Kim, J., Kim, S., Lee, S. Y., “Metabolic Engineering of Corynebacterium glutamicum for Large-scale Production of L-Arginine”, 2018 KSBB International Academia-Industry Joint Meeting, The Korean Society for Biotechnology and Bioengineering, Sejong University Convention Center, Seoul, 10-12 October 2018
Han, T., Shin, J., Cho, J., Lee, S.Y., “Metabolic engineering of Corynebacterium glutamicum for enhanced production of 5‑aminovaleric acid”, Metabolic Engineering 2018, Munich, Germany, June 24-28, 2018
Han, T., Kim, S. Y., Lee, J. M., Lee, S. Y., “Metabolic engineering of Corynebacterium glutamicum for enhanced production of L-ornithine”, 2018 KIChE Spring Meeting and International Symposium, The Korean Institute of Chemical Engineers, Ceco, Changwon, Korea, 25-27 April, 2018
Han, T., Sin, J. H., Cho, J. S., Lee, S. Y., “Metabolic Engineering of Corynebacterium glutamicum for enhanced production of 5-aminovaleric acid”, 2018 KIChE Spring Meeting and International Symposium, The Korean Institute of Chemical Engineers, Ceco, Changwon, Korea, 25-27 April, 2018
Han, T., Cho, J. S., Park, S. H., Kim, H. U., Kim, T. Y., Lee, S. Y., “Metabolic Engineering of Corynebacterium glutamicum for Large-scale production of L-Arginine”, 2017 KIChE Fall Meeting and International Symposium, The Korean Institute of Chemical Engineers, DCC, Daejeon, 25-27 October 2017
Han, T., Cho, J. S., Park, S. H., Lee, S. Y., “Metabolic Engineering of Corynebacterium glutamicum for Production of 1,5-diaminopentane”, 2017 KIChE Fall Meeting and International Symposium, The Korean Institute of Chemical Engineers, DCC, Daejeon, 25-27 October 2017