What is Sorafenat 200 mg?

Drug indications:

- metastatic renal cell carcinoma;

- hepatocellular carcinoma

Method of application:

Inside. The recommended dose is 800 mg / day. Sorafenat can be taken on an empty stomach and with food. It is desirable that the food does not contain a large amount of fat, because it helps to reduce the bioavailability of sorafenib.

Treatment with Sorafenib 200mg is discontinued if the clinical effect disappears.

The drug should also be discontinued if an unacceptable toxic effect occurs during the treatment with Sorafenat.

A dose reduction of up to 400 mg / day may be required if various side effects occur.

There are no data on the use of Sorafenat in patients with severely impaired liver function and in patients who are on hemodialysis.

Special instructions:

Sorafenat treatment is carried out under the supervision of a physician who has experience in antitumor therapy.

During the entire course of Sorafenat administration, monitoring of peripheral blood parameters (leukocyte formula and platelets) is required.

The most common adverse reactions when taking Sorafenat were skin reactions, especially in the limbs, and rash. As a rule, they were of the 1st or 2nd degree of severity, and their manifestation was noted during the first 6 weeks of therapy. Such adverse reactions can be stopped by lowering the dose of Sorafenat, appropriate treatment. With repeated repetition of these side effects, as well as in the case of their severe manifestation, treatment with sorafenib cannot be continued.

During the course of taking Sorafenat, it is necessary to regularly monitor the patient's blood pressure to prevent the development of arterial hypertension. If necessary, prescribe antihypertensive drugs. With the development of severe or persistent hypertension, drug withdrawal is possible.