Finding a Clue in (Population) Cohorts

Cohort dataset provides a wide range of metadata (i.e. food intake, lifestyle, medication, blood chemistry and clinical assessments). Assocition study between various factors reported in the cohort and the human microbiome will tell us where to begin our in-depth investigation! For example, the red wine study identified a negative link between redwine consupmtion frequency and BMI based on multiple international population cohort. Then, we can further move on to the mechanistic study to learn how it happens. Also, we have discovered a clue about the relationship between Bacteroides and Akkermansia based on one of the largest cohorts in Korea. We are currently working across many intriguing cohorts to determine how host health is regulated by interactions between the host and the microbiome.

Microbial Cross-Talk In the Host and With the Host

In addition to the trillions of mcrobes already present in our bodies, there are additional potent compounds that could be part of the microbial cells or the compounds they produce. These extra substances can expand the explation on the host-microbes interactions and their effect in host health modulation. We utilize small intestine organoids/animal models to understand the mehanistic links we observed in cohort studies.