Dr. Chalermchai Somboonpatarakun obtained a PhD in Biochemistry from Khon Kaen University. For his PhD thesis, he explored the roles of His101 on structure and function of goose-type lysozyme. After finishing the PhD, he worked as a postdoc for two years in Parasitology, Faculty of Medicine, Khon Kaen University. He identified and cloned the parasite antigen that was specific to antibody in patient serum and used this recombinant as a target antigen in ICT kit to detect antibodies for rapid diagnosis of human angiostrongyliasis. He is currently a researcher of Siriraj Center of Research Excellence for Cancer Immunotherapy, Faculty of Medicine, Siriraj Hospital, Mahidol University. His current research interest is in cancer cellular immunotherapy, especially adoptive T cell transfer using chimeric antigen receptor (CAR) T cells and the use of self-differentiated monocyte-derived dendritic cells (SD-DC) to improve ex vivo activation of autologous effector T cells.

• Molecular cloning

• Protein-protein interaction

• Chimeric antigen receptor

• Cancer immunotherapy

1. Somboonpatarakun C., Shinya S., Kawaguchi Y., Araki T., Fukamizo T., Klaynongsruang S. (2016) A goose-type lysozyme from ostrich (Struthio camelus) egg white: multiple roles of His101 in its enzymatic reaction. Biosci Biotechnol Biochem 80(2): 264-272.

2. Somboonpatarakun C., Fukamizo T., Araki T., Klaynongsruang S. (2016) Role of His101 in the protein folding/unfolding of a goose-type lysozyme from ostrich (Struthio camelus) egg white. Protein J 35(6): 416-423.

3. Somboonpatarakun C., Rodpai R., Intapan P.M., Sanpool O., Sadaow L., Wongkham C., Insawang T., Boonmars T., Maleewong W. (2018) Immuno-proteomic analysis of Trichinella spiralis, T. pseudospiralis, and T. papuae extracts recognized by human T. spiralis-infected sera. Parasitol Res 117(1): 201-212.

4. Somboonpatarakun C., Intapan P.M., Sanpool O., Wongkham C., Maleewong W. (2019) Application of recombinant Angiostrongylus cantonensis galectin-2 protein for serodiagnosis of human angiostrongyliasis by immunoblotting. Am J Trop Med Hyg 101(4): 851-858.

5. Somboonpatarakun C., Intapan P.M., Sadaow L., Rodpai R., Sanpool O., Maleewong W. (2020) Development of an immunochromatographic device to detect antibodies for rapid diagnosis of human angiostrongyliasis. Parasitology 147(2): 194-198.

6. Thanchomnang T., Intapan P.M., Sanpool O., Rodpai R., Sadaow L., Phosuk I., Somboonpatarakun C., Laymanivong S., Tourtip S., Maleewong W. (2019) First molecular identification of Strongyloides fuelleborni in long-tailed macaques in Thailand and Lao People’s Democratic Republic reveals considerable genetic diversity. J Helminthol 93(5): 608-615.

7. Boonroumkaew P., Sanpool O., Rodpai R., Sadaow L., Somboonpatarakun C., Laymanivong S., Aung W.P.P., Un M., Laummaunwai P., Intapan P.M., Maleewong W. (2019) Molecular identification and genetic diversity of Gnathostoma spinigerum larvae in freshwater fishes in southern Lao PDR, Cambodia, and Myanmar. Parasitol Res. 118(5): 1465-1472.

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