I currently work at the Department of Biology, Chiang Mai University. My research projects are in the field of Cancer Immunotherapy. In the past few years, my research team develop the ex vivo production of cellular immunotherapy for cancer treatment including self-differentiated dendritic cells, activated adoptive T cells, natural killer cells, and genetically modified chimeric-antigen-receptor expressing immune cell (CAR-T and CAR-NK cells). The efficacy of our products in destroying target cancer cells has been reported in international peer-reviewed journals. Besides the production line of cellular immunotherapy, we are interested in the discovery of immunomodulatory agents to enhance the activity of our cellular immunotherapy. We are investigating the effect of chemotherapy drugs and bioactive agents on modulating the cytotoxicity of immune cells to combat the cancer cells to develop the combined therapy for cancer patients. Hopefully, our findings can pave a way for alternative cancer treatment for patients.

• Molecular genetics and biology

• Cancer immunotherapy

• Immuno-modulatory agent

• Drug design and development

1. Panya A, Pundith H, Thongyim S, Kaewkod T, Chitov T, Bovonsombut S, Tragoolpua Y. Antibiotic-Antiapoptotic Dual Function of Clinacanthus nutans (Burm. f.) Lindau Leaf Extracts against Bovine Mastitis. Antibiotics (Basel) 2020 Jul 21;9(7):429. doi: 10.3390/antibiotics9070429 (ISI, IF=3.893, Q1)

2. Semsri S, Seatew C, Rattanabunyong S, Ruekit S, Horata N, Panya A,  Yenchitsomanus PT, Sawatdichaikul O,  Choowongkomon K. In-vitro studies of anti-egfr tyrosine kinase activity of thai nutraceutical plants. Iranian Journal of Pharmaceutical Research, 2020, 19(2), pp. 196-206 (Scopus)

3. Junking, M., Rattanaburee, T., Panya, A., Budunova I.,Haegeman, G., Yenchitsomanus, P.-T. Anti-proliferative effects of compound a and its effect in combination with Cisplatin in Cholangiocarcinoma Cells. Asian Pacific Journal of Cancer Prevention, 2020, 21(9), pp. 2673-2681 (Scopus)

4. Thepmalee C, Panya A, Sujjitjoon J, Sawasdee N, Poungvarin N, Junking M, Yenchitsomanus PT. Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells. Hum Vaccin Immunother. 2020 Jan 24:1-10. doi: 10.1080/21645515.2019.1701913. (ISI, IF=2.619, Q2)

5. Sawasdee N, Thepmalee C, Sujjitjoon J, Yongpitakwattana P, Junking M, Poungvarin N, Yenchitsomanus PT, Panya A. Gemcitabine enhances cytotoxic activity of effector T-lymphocytes against chemo-resistant cholangiocarcinoma cells. Int Immunopharmacol. 2020 Jan;78:106006. doi: 10.1016/j.intimp.2019.106006. (ISI, IF=3.943, Q1)

6. Jungtrakoon P, Shirakawa J, Buranasupkajorn P, Gupta MK, De Jesus DF, Pezzolesi MG, Panya A, Hastings T, Chanprasert C, Mendonca C, Kulkarni RN, Doria A. Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes. Diabetes. 2019 May;68(5):1084-1093. doi: 10.2337/db17-0821. (ISI, IF=7.199, Q1)

7. Phumesin P, Junking M, Panya A, Yongpitakwattana P, Noisakran S, Limjindaporn T, Yenchitsomanus PT. Inhibition of dengue virus replication in monocyte-derived dendritic cells by vivo-morpholino oligomers. Virus Res. 2019 Jan 15;260:123-128. doi: 10.1016/j.virusres.2018.11.014. (ISI, IF=2.736, Q3)

8. Panya A, Yongpitakwattana P, Budchart P, Sawasdee N, Krobthong S, Paemanee A, Roytrakul S, Rattanabunyong S, Choowongkomon K, Yenchitsomanus PT. Novel bioactive peptides demonstrating anti-dengue virus activity isolated from the Asian medicinal plant Acacia Catechu. Chem Biol Drug Des. 2019 Feb;93(2):100-109. doi: 10.1111/cbdd.13400. Epub 2018 Oct 10. (ISI, IF=2.256, Q3)

9. Panya A, Thepmalee C, Sawasdee N, Sujjitjoon J, Phanthaphol N, Junking M, Wongkham S, Yenchitsomanus PT. Cytotoxic activity of effector T cells against cholangiocarcinoma is enhanced by self-differentiated monocyte-derived dendritic cells. Cancer Immunol Immunother. 2018 Oct;67(10):1579-1588. (ISI, IF=4.900, Q1)

10. Thepmalee C, Panya A, Junking M, Chieochansin T, Yenchitsomanus PT.Inhibition of IL-10 and TGF-ß receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells. Hum Vaccin Immunother. 2018 Jun 3;14(6):1423-1431. (ISI, IF=2.592, Q2)

11. Phumesin P, Junking M, Panya A, Yongpitakwattana P, Noisakran S, Limjindaporn T, Yenchitsomanus PT. Vivo-morpholino oligomers strongly inhibit dengue virus replication and production. Arch Virol. 2018 Apr;163(4):867-876. (ISI, IF=2.261, Q3)

12. Navakul K., Warakulwit C., Yenchitsomanus P., Panya A., Lieberzeit P. and Sangma C. Novel Method for Dengue Virus Detection and Antibody Screening Using a Graphene-Polymer Based Electrochemical Biosensor. Nanomedicine. 2017 Feb;13(2):549-557. doi: 10.1016/j.nano.2016.08.009. Epub 2016 Aug 21. (ISI, IF=4.717, Q1)

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