I have an educational background in Medical Science and Biochemistry. I received a Ph.D. degree in Biochemistry from Mahidol University and then received an M.D. degree (second Honor) at the Faculty of Medicine, Ramathibodhi hospital, Mahidol university. I earn work experience as a postdoctoral fellow in Molecular Carcinogenesis under the supervision of Professor Norman Drinkwater, Director of McArdle Laboratory for Cancer Research at the University of Wisconsin, USA. My research works involved genetics/genomics and molecular biology studies of cancer. My current research interest in cellular immunotherapy of cancer is focused on the tumor microenvironment in cancer progression and drug resistance, cancer-associated fibroblasts and cancer cell interaction, cancer immunotherapy-dendritic cell-based / Peptide-based T cell therapy and artificial intelligence, and immune cell evaluation.

• Tumor microenvironment in cancer progression and drug resistance

• Cancer-associated fibroblasts and cancer cell interaction

• Cancer immunotherapy-dendritic cell-based / Peptide-based T cell therapy

• Artificial intelligence and immune cell evaluation

1. Thongchot S, Jamjuntra P, Therasakvichya S, Warnnissorn M, Ferraresi A, Thuwajit P, Isidoro C*, Thuwajit C*. Interleukin-8 released by cancer-associated fibroblasts attenuates the autophagy and promotes the migration of ovarian cancer cells. Int J Oncol 2021 May;58(5):14. doi: 10.3892/ijo.2021.5194. Epub 2021 Mar 2. (Q2, IF 3.899)

2. Kyaw Oo K, Kamolhan T, Soni A, Thongchot S, Mitrpant C, O-charoenrat P, Thuwajit C, Thuwajit P*. Development of an engineered peptide antagonist against periostin to overcome doxorubicin resistance in breast cancer cells. BMC Cancer 2021 Jan 14;21(1):65. doi: 10.1186/s12885-020-07761-w (Q2, IF 3.150)

3. Luangwattananun P, Junking M, Sujjitjoon J, Wutti-in Y, Poungvarin N, Thuwajit C, Yenchitsomanus P*. Fourth-generation chimeric antigen receptor T cells targeting folate receptor alpha antigen expressed on breast cancer cells for adoptive T cell therapy. Breast Cancer Res Treat 2021 Jan 3. doi: 10.1007/s10549-020-06032-3 (Q1, IF 3.831)

4. Ngamkham J, Thuwajit C, Thuwajit P, Khamwachirapitha P, Lertsuwan K, Charoensawan V, Jitrapakdee S*. Overexpression of pyruvate carboxylase is correlated with colorectal cancer progression and supports growth of invasive colon cancer HT-29 cell line. Anticancer Res 2020, 40(11), 6285-6293 (Q2, IF 1.994)

5. Thongchot S, Singsuksawat E, Sumransub N, Pongpaibul A, Trakarnsanga A, Thuwajit P, Thuwajit C*. Periostin regulates autophagy through integrin α5β1 or α6β4 and an AKT-dependent pathway in colorectal cancer migration. J Cell Mol Med 2020, 00, 1-12, doi:10.111/jcmm.15756 (Q1, IF 4.486)

6. Yangngam Y, Thongchot S, Pongpaibul A, Vaeteewoottacharn K, Thuwajit P, Thuwajit C*. High level of interleukin-33 in cancer cells and cancer-associated fibroblasts correlates with good prognosis and suppressed migration in cholangiocarcinoma. J Cancer 2020, 11(20), 6571-6581 (Q2, IF 3.565)

7. Sukjo W, Siritutsoontorn S, Chansongkrow P, Waiwitlikhit S, Polyak SW, Warnnissorn M, Varodom Charoensawan V, Thuwajit C, Jitrapakdee S*. Overexpression of holocarboxylase synthetase predicts lymph node metastasis and unfavorable prognosis in breast cancer. Anticancer Res 2020, 40, 4557-4565 (Q2, IF 1.994)

8. Sonongbua J, Siritungyong S, Kamolhan T, Utispan K, Thuwajit P, Pongpaiboon A, Wongkham S, and Thuwajit C*. Integrin alpha5beta1-TWIST-2 axis induces epithelial-to-mesenchymal transition in cholangiocarcinoma and indicates TWIST-2 as a poor prognostic marker. Oncol Rep 2020, 43: 1147-1158, 2020, DOI: 10.3892/or.2020.7485 (Q1, IF 3.411)

9. Sumransub N, Jirapongwattana N, Jamjuntra P, Thongchot S, Chieochansin T, Yenchitsomanus P, Thuwajit P, Warnnissorn M, O-Charoenrat P, Thuwajit C*. Breast cancer stem cell RNA-pulsed dendritic cells enhance tumor cell killing by T cells. Oncol Lett 2020, 19, 2422-30 (Q3, IF 2.311)

10. Utaijaratrasmi P, Vaeteewoottacharn K, Tsunematsu T, Jamjantra P, Wongkham S, Pairojkul C, Khuntikeo N, Ishimaru N, Sirivatanauksorn Y, Pongpaibul A, Thuwajit P, Thuwajit C*, Kudo Y*. The MicroRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migration of cancer cells. Mol Cancer 2018 Jan 18;17(1):10. doi: 10.1186/s12943-018-0760-x (Q1, IF 10.679)

11. Sootichote R, Thuwajit P, Singsuksawat E, Warnnissorn M, Yenchitsomanus P, Ithimakin S, Chantharasamee J, Thuwajit C*. Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8. BMC Cancer 2018, Feb 27:18(1): 231. doi: 10.1186/s12885-018-4155-6 (Q1, IF 3.288)

12. Singsuksawat E, Thuwajit C, Charngkaew K, Thuwajit P*. Increased ETV4 expression correlated with estrogen-enhanced proliferation and invasivenss of cholangiocarcinoma cells. Cancer Cell Inter 2018, Feb 20;18:25. doi: 10.1186/s12935-018-0525-z (Q2, IF 2.740)

13. Prachayakul V, Kanchanapermpoon J, Thuwajit C, Boonyaarunnate T, Pongpaibul A, Chobson P, Thuwajit P*. DNA methylation markers improve the sensitivity of endoscopic retrograde cholangiopancreatography-based brushing cytology in extrahepatic cholangiocarcinoma. Tech Cancer Res Treat 2017, Dec, 16(6), 1252-58 (Q2, IF 2.204)

14. Thuwajit C, Titone R, Morani F, Thuwajit P, Isidoro C*. The metabolic cross-talk between epithelial cancer cells and stromal fibroblasts in ovarian cancer progression: autophagy plays a role. Med Res Rev 2017 Sep 19. doi: 10.1002/med.21473 (Q1, IF 8.763)

15. Thuwajit C*, Thuwajit P, Jamjantra P, Pairojkul C, Wongkham S, Bhudhisawasdi V, Ono J, Ohta S, Fujimoto K, Izuhara K. Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may predictive of prognosis, Oncol Lett 2017, 14, 623-634 (Q3, IF 1.482)

16. Amornsupak K, Jamjuntra P, Warnnissorn M, O-Charoenrat P, Sa-nguanraksa D, Thuwajit P, Eccles SA, Thuwajit C*. High ASMA-positive fibroblasts and low cytoplasmic HMGB1-positive breast cancer cells predict poor prognosis. Clin Breast Cancer 2017 Apr 21. pii: S1526-8209(16)30580-8. doi: 10.1016/j.clbc.2017.04.007 (Q2, IF 3.082)

17. Prachayakul V, Kanchanapermpoon J, Thuwajit C, Boonyaarunnate T, Pongpaibul A, Chobson P, Thuwajit P*. Plasma lipidomics as a tool for diagnosis of extrahepatic cholangiocarcinoma in biliary strictures: a pilot study, Asian Pac J Cancer Prev 2016, Aug, 17(8), 4155-62 (Q2, IF 2.514)

1. Honorable to be A Visiting Professor at Kumamoto University 2020-2022, Graduate School of Medical Sciences, Kumamoto University, Japan

2. Outstanding Preclinical Research Award 2019, Faculty of Medicine Siriraj Hospital, Mahidol University

3. Outstanding Alumni 2019, Faculty of Medicine Ramathibodhi Hospital, Ramathibodhi Alumni Association, Mahidol University

4. Biochemistry and Molecular Biology Award for Research Excellence (Prof. M.R. Jisnuson Svasti Award) 2018, from The Biochemistry and Molecular Biology Section, Science Society of Thailand under the Patronage of His Majesty the King

5. Exchanger Researcher Scholars since 2018, Faculty of Medicine Siriraj Hospital, Mahidol University

6. Honorable to be A Visiting Associate Professor at Kumamoto University 2018-2019, Graduate School of Medical Sciences, Kumamoto University, Japan

7. Major Advisor’s Role on the Distinguished Ph.D. Thesis Award, Mahidol University 2018

8. Ananda Mahidol Foundation Graduate Grant for Medicine, 2013-2015