Negative One takes place before the events of Infection Avenue at the Vertex Dynamics Lab As four scientist and others (More so Johnson, Matthews, and Andrew) try to escape the facility being taken over. Dr. Johnson, the owner of the facility. Dr. Matthews, his most trusted scientist. Dr. Brown, is... there isn't much to say about him. and Dr. Andrew, Dislikes Johnson and Matthews but ends up being "friends" with them by the end.