Ultrathin flexible electronics can be implanted to the adrenal gland of the animals.

The multichannel electrode array is capable of capturing electrophysiological signals from both the adrenal cortex and adrenal medulla. These two components are responsible for the chronic stress response and acute stress response, respectively.

The adrenal cortex tissue exhibits an amplified signal response to the artificial stress condition, specifically in response to the injection of ACTH, whereas the adrenal medulla tissue remains silent.

Under actual stress conditions, such as during the forced swim test, both the signals originating from the adrenal cortex and medulla experience a notable and simultaneous increase.

Thanks to the biocompatibility of the device, the animals have not only survived for more than 12 weeks but have also consistently provided reliable signals throughout this chronic monitoring period.

Special thanks for

Professor Tae-il Kim (Sungkyunkwan Univsersity, Korea)

Professor Young Jin Choi (Sejong University, Korea)

Professor Soo Wan Kim (Chonnam University Hospital, Korea)