News

• January 2025, Wang et al COORS paper published in Neuro-Oncology Advances

• December 2024, McDonald et al paper posted in Cancer Research Communications

• October 2024, Curry et al SCRAM paper published in Cancer Cell (featured as front cover in Houston Chronicles)

• May 2024, Shetty et al CLIPPR paper published in Journal of Neuro-oncoloy (featured as Journal Cover)

Research

The development and application of new deep molecular profiling methods such as single-cell RNA sequencing and spatial transcriptomics have revolutionized the entire field of biology thus enabling us to study the cellular heterogeneity of the brain tumors. However, computational tools are needed to translate these large-scale and complex datasets. Therefore, in our lab we focus on developing integrative approaches to dissect the molecular landscape of brain tumors using single-cell RNA sequencing and spatial transcriptomics data. We are developing new methods for understanding the interplay of immune, neuron and tumor cells in brain tumors using scRNA-Seq for developing targeted therapies. 

Our primary research goal is to develop novel integrative methods to determine an individual’s unique molecular characteristics and use those genetic features to suggest targetable genes, drugs and treatments specific to each patient.