Plant cell divided in a microfluidic device.
We are the SEARCH team – a group of young enthusiastic researchers from different fields inside the EEMCS faculty of the University of Twente, namely the fields of engineering, computer science and mathematics. Our goal is to combine our expertise in engineering, mathematics and artificial intelligence to find the perfect plant cell, which will give birth to a new tree!
To find the perfect plant cell, we need to analyze the cells. For this purpose, we use microfluidics to image single cells over time and to apply various stresses for investigating the response of the plant cell to stress. Subsequently, we use artificial intelligence (AI) tools and mathematical modeling to analyze the generated images. We believe that the integration of AI tools will make the analysis process more consistent, reliable and easy. Furthermore, the mathematical modeling aids in analyzing the plants cells by, among others, creating prediction models for plant cell division, which in turn makes it easier to choose the best plant cell for further genetic modification purposes.
SEARCH team
from left to right:
PhD candidate Daria (Dasha) Bugakova,
Dr. Nicola Strisciuglio,
Prof.dr.ir Loes Segerink,
PhD candidate Shunxin Wang,
PhD candidate Sven Dummer,
Prof. dr. Christoph Brune
Learn more about the microfluidic setup used to track single plant cells
Discover our artificial intelligence (AI) method for characterizing the dynamic evolution of plant cells.
Develop image analysis models under the influence of out-of-focus blur and noisy annotations.
In contrast to existing approaches that measure average cell population characteristics (e.g., shape, size, or expression of proteins), we proposed to track and characterize the change of single cells on a microfluidic scale and under stimuli over time.
Sven, Dasha & Shunxin spotted at Efteling roller-coaster, July 2023.
SEARCH team is not only about the scientific research - we also do lots of fun activities together! As a part of PhDs teambuilding activity, Shunxin, Sven and Dasha are going to one of the largest amusement parks in the Netherlands this Saturday - Efteling!
Shunxin got a paper accected at ICCV2023. Title of the paper "What do neural networks learn in image classification? A frequency shortcut perspective".
Shunxin is receiving her best poster award!
Shunxin won the best abstract award at the spring meeting 2023 for Robust AI in Nijmegen. Title of Abstract "The Impact of Frequency Shortcuts on Out-of-Distribution Generalization"
Dasha spotted at NWO Dutch Biophysics Conference, October 2022.
Dasha is going to attend annual NWO Dutch Biophysics Conference in Veldhonve in October 2023. Meet her there at the poster spot 82 if you want to learn more about microlfuidcs applied to plant cells!
"Spheres attack" - plant protoplasts on the edge of the Petri dish.
Dasha won the MESA+ Institute Photo contest, where researchers within the university can present beautiful art works of their scientific research.