Challenges and opportunities in formulating drug delivery systems (P. Luciani)

The development of innovative drug delivery systems presents an evolving landscape of challenges and opportunities that are pivotal for advancing therapeutic outcomes. Critical formulation issues include ensuring drug stability, controlling release kinetics, and achieving targeted delivery while minimizing side effects. These hurdles are compounded by the complexities of biological environments and the variability in patient responses, often calling for personalized approaches.

Besides classical dosage forms, nanocarriers, such as liposomes, dendrimers, and polymeric nanoparticles, have shown significant potential in enhancing drug solubility, stability, and bioavailability. Additionally, stimuli-responsive systems that release drugs in response to specific physiological triggers, such as pH or temperature changes, present innovative solutions for controlled and site-specific delivery.

This contribution will highlight the importance of interdisciplinary collaboration in addressing the challenges and harnessing the opportunities in drug delivery system formulation. By bridging the gap between laboratory research and clinical application, we can accelerate the development of next-generation therapeutics that offer enhanced efficacy and patient compliance.