Publisher: Physiological Society of Nigeria
Title: Safety Evaluation of Osun River Water Containing Heavy Metals and Volatile Organic Compounds (VOCs) in Rats
Author: Azeez L., Salau A.K., Adewuyi S.O., Osineye S.O., Tijani K.O., Balogun R.O.
Date of Publication: 2015
Type: Research Study
Volume: 30
Citation style language: Information not available in the sources
Pollution Type:
Heavy metals: Lead (Pb), Cadmium (Cd), Zinc (Zn), Iron (Fe), Chromium (Cr), Copper (Cu)
Volatile Organic Compounds (VOCs): Benzene, ethylbenzene, toluene, xylene
Impact Dimension:
Environmental
Health
Biological
Actor Type:
Researchers
Scientists
Response Type:
Scientific Assessment
Evaluation Study
Evidence Type:
Empirical data
Laboratory experiment (rat study)
Chemical analysis (water)
Policy Mention:
Standards Organization of Nigeria (SON) permissible limits
World Health Organization (WHO) drinking water guidelines
NIH Guide for the Care and Use of Laboratory Animals
Good Laboratory Procedure (GLP)
Key Finding:
Lead (Pb), cadmium (Cd), and benzene exceeded permissible limits
Exposure induced hematological imbalance and liver cell injury in rats
Toxicity in blood parameters was sex-dependent (more severe in females)
Decreased liver glutathione; increased liver TBARS, serum proteins, and serum aminotransferases
Health Risk Projection:
Pollutants induce hematological imbalance and liver injury
Confirmed carcinogens causing oxidative stress (damages DNA, proteins, cellular constituents)
Linked to diarrhea, cholera, dysentery, typhoid, poliomyelitis, morbidity, mortality
May cause cancers, respiratory diseases, organ failure, mental retardation, gastrointestinal disorders, tremor, ataxia, paralysis, vomiting, convulsions, depression, pneumonia, leukemia
Osun River water unsafe for drinking
URL: https://www.ajol.info/index.php/njps/article/view/145524
DOI: Information not available in the sources
ISBN, ISSN, PMID: Information not available in the sources