Group leader (SNSF Ambizione 2020)
Neuroimmunologist dedicated to elucidate homeostatic and pathogenic neuroimmune interactions.
I want to contribute to a deeper understanding of immune-mediated brain disorders and to unravel the impact of CNS/immune cell-crosstalk during disease but, importantly, also in the steady state. My research uses conditional gene targeting, multi-parameter cytometry approaches and high-dimensional computational data mining.
Pascale Zwicky, Florian Ingelfinger, Bruno de Melo, Fiorella Ruchti, Stefanie Schärli, Nicole Puertas, Mirjam Lutz, Truong San Phan, Thomas M. Kündig, Mitchell Levesque, Julia-Tatjana Maul, Christoph Schlapbach, Salome LeibundGut-Landmann, Sarah Mundt* & Burkhard Becher*. IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. Science Immunology (2021), 6(64), eabg9012. https://doi.org/10.1126/sciimmunol.abg9012; * shared last authorship
Florian Ingelfinger, Sinduya Krishnarajah, Michael Kramer, Sebastian G. Utz, Edoardo Galli, Mirjam Lutz, Pascale Zwicky, Ayse U. Akarca, Nicole Puertas Jurado, Can Ulutekin, David Bamert, Corinne C. Widmer, Luca Piccoli, Federica Sallusto, Nicolás G. Núñez, Teresa Marafioti, Didier Schneiter, Isabelle Opitz, Antonio Lanzavecchia, Hans H. Jung, Donatella De Feo, Sarah Mundt, Bettina Schreiner & Burkhard Becher. "Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature." Acta Neuropathol (2021). https://doi.org/10.1007/s00401-021-02299-y
Sarah Mundt, Annika Keller, Melanie Greter. "The dural sinus hub: more than just a brain drain". Cell (2021), Feb 18, 184(4), P858-860
Truong San Phan, Leonhard Schink, Jasmin Mann, Verena M Merk, Pascale Zwicky, Sarah Mundt, Dagmar Simon, Dagmar Kulms, Susanne Abraham, Daniel F Legler, Mario Noti, Thomas Brunner "Keratinocytes control skin immune homeostasis through de novo–synthesized glucocorticoids". Science Advances (2021), Jan 29, 7(5)
Christian W. Keller , Monika B. Kotur , Sarah Mundt , Nikolaos Dokalis , Laure-Anne Ligeon , Ajay M. Shah , Marco Prinz , Burkhard Becher , Christian Münz & Jan D. Lünemann. "CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation" - Autophagy (2020) May 13; 1-15
Sarah Mundt, Alexander Flügel, Melanie Greter, Burkhard Becher. "The CNS Immune Landscape from the Viewpoint of a T cell“. Review article for Trends in Neurosciences 2019 Aug 29; 42(10)
Sarah Mundt, Dunja Mrdjen, Sebastian Utz, Melanie Greter, Bettina Schreiner, Burkhard Becher. “CNS-resident conventional dendritic cells process and present myelin antigen to encephalitogenic T cells” - Sci Immunol. 2019 Jan 25; 4(31)
Christian Keller, Christina Sina, Guilia Ramelli, Sarah Mundt, Isaak Quast, Patrick Weber, Burkhard Becher, Christian Münz, Jan Lünemann. “ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation.” Proc Natl Acad Sci USA. (2017) Dec 26; 114(52)
Michael Basler, Sarah Mundt, Marcus Groettrup. “The immunoproteasome subunit LMP7 is required in the thymus for filling up a hole in the T cell repertoire” Eur J Immunol. (2017) Oct 24; 48(3)
Sarah Mundt, Birgit Sawitzki, Michael Basler, Marcus Groettrup. "No prolongation of skin allograft survival by immunoproteasome inhibition in mice" Mol Immunol. (2017) Jun 2; 88:32-37.
Sarah Mundt, Michael Basler, Stefanie Bürger, Harald Engler, Marcus Groettrup. "Inhibiting the immunoproteasome exacerbates pathogenesis of systemic Candida albicans infection in mice” Sci Reports, (2016), Jan 18; 6:19434.
Sarah Mundt, Britta Engelhardt, Christopher J. Kirk, Marcus Groettrup, Michael Basler. "Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis" Eur J Immunol. (2016) Jan; 46(1).
Michael Basler, Sarah Mundt, Annegret Bitzer, Christian Schmidt, and Marcus Groettrup. "The immunoproteasome: A novel drug target for autoimmune diseases." Clin Exp Rheumatol. (2015) Jul-Aug; 33(4 Suppl 92).
Stefanie Buerger, Valerie Herrmann, Sarah Mundt, Nico Trautwein, Stefan Stevanovic, Marcus Groettrup, and Michael Basler. "The ubiquitin-like modifier FAT10 is selectively expressed in medullary thymic epithelial cells and modifies T cell selection in the thymus” J Immunol. (2015) Nov 1; 195(9)
Sarah Mundt, Marcus Groettrup & Michael Basler. “Analgesia in mice with experimental meningitis reduces pain without altering immune parameters” ALTEX, (2015) Mar 24; 32(3):183-9
Michael Basler*, Sarah Mundt*, Tony Muchamuel*, Carlo Moll, Jing Jiang, Marcus Groettrup, Christopher J. Kirk. "Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis." EMBO Mol Med. (2014), Jan 16; 6(2) * shared first authorship
Contribution to international conferences and workshops
Neuro-Immune Axis: Reciprocal Regulation in Development, Health, and Disease – Long Beach, CA, USA, September 2019 (poster presentation)
II Joint Meeting of the German Society for Immunology (DGfl) and the Italian Society of Immunology, Clinical Immunology and Allergology (SIICA) – Munich, Germany, September 2019 (oral presentation)
14th International Congress of Neuroimmunology (ISNI 2018) – Brisbane (Australia), August 2018 (oral presentation)
15th International Symposium on Dendritic Cells - Aachen (Germany), June 2018 (poster presentation)
Immunology retreat (A. Waisman, B. Becher, R. Liblau) – Bonndorf (Germany), May 2018 (oral presentation)
SSAN Salvisberg Symposium on Advances in Neuropathology (Prof. Adriano Aguzzi) – Bludenz (Austria), September 2017 (oral presentation)
Immunology retreat (A. Waisman, B. Becher, R. Liblau) – Annecy (France), July 2017 (oral presentation)
CRPP MS Symposium "Heterogeneity of autoimmune diseases" - University of Zurich (Switzerland), June 2017 (poster presentation)
Immunology retreat (A. Waisman, B. Becher, R. Liblau) – Annecy (France), June 2016 (oral presentation)
SFB 969-Symposium "Two Days of Proteostasis in Konstanz" - University of Konstanz (Germany), October 2014 (oral presentation)
44th Annual Meeting of the German Society for Immunology – World Conference Center Bonn (Germany), September 2014 (poster presentation)
65th Lindau Nobel Laureate Meeting – Lindau/ Mainau (Germany), July 2014 (poster presentation)
8th International Workshop on “Antigen Processing & Presentation“ - The Academy of Natural Sciences of Drexel University in Philadelphia (USA), June 2014 (poster presentation)
43th Annual Meeting of the German Society for Immunology - Mainz (Germany), September 2013 (poster presentation)
Swiss MS Researcher Meeting 2013 - University of Bern (Switzerland), August 2013
5th Student Symposium on Molecular Medicine - Ulm University (Germany), July 2012 (oral presentation)
Scientific presentations as invited speaker
Data presentation (invited speaker): “Algorithm guided high-dimensional data analysis using R” – Idorsia Pharmaceuticals Ltd, Allschwil (Switzerland), May 2019
Lecture (invited speaker): “Characterization of CNS APCs - who tells encephalitogenic T cells they have arrived?” - University of Konstanz (Germany), December 2018