Research

Group leader (SNSF Ambizione 2020)

Neuroimmunology lab, Institute of Experimental Immunology, University of Zurich

Neuroimmunologist dedicated to elucidate homeostatic and pathogenic neuroimmune interactions.

I want to contribute to a deeper understanding of immune-mediated brain disorders and to unravel the impact of CNS/immune cell-crosstalk during disease but, importantly, also in the steady state. My research uses conditional gene targeting, multi-parameter cytometry approaches and high-dimensional computational data mining.

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Publications

  1. Mundt, S., Greter, M., & Becher, B. (2022). The CNS mononuclear phagocyte system in health and disease. Neuron, 110(21), 3497–3512. https://doi.org/10.1016/j.neuron.2022.10.005. First authorship; I conceptualized and wrote the manuscript

  2. Andreadou, M.; Ingelfinger, F.; De Feo, D.; Friebel, E.; Tuzlak, S.; Cramer, T. M. L.; Schreiner, B.; Eede, P.; Schneeberger, S.; Geesdorf, M.; Ridder, F.; Welsh, C.; Kirschenbaum, D.; Tyagarajan, S. K.; Greter, M.; Heppner, F. L.; Mundt, S.*; Becher, B.* Neuroprotective Tissue Adaptation Induced by IL-12 Attenuates CNS Inflammation. bioRxiv 2022, 2022.09.14.506749. https://doi.org/10.1101/2022.09.14.506749. *Shared last authorship, I conceptualized the study, supervised the PhD student, wrote the manuscript and acquired funding

  3. Ingelfinger, F., Sparano, C., Bamert, D., Reyes-Leiva, D., Sethi, A., Rindlisbacher, L., Zwicky, P., Kreutmair, S., Widmer, C. C., Mundt, S., Cortés-Vicente, E., Tugues, S., Becher, B., & Schreiner, B. (2022). Azathioprine therapy induces selective NK cell Depletion and IFN-γ Deficiency predisposing to herpes virus reactivation. The Journal of allergy and clinical immunology, S0091-6749(22)01187-3. Advance online publication. https://doi.org/10.1016/j.jaci.2022.09.010. Co-authorship; Mentorship of the PhD student, providing intellectual input for the experimental approach and data analysis, critical review of the manuscript

  4. Ingelfinger, F., Gerdes, L. A., Kavaka, V., Krishnarajah, S., Friebel, E., Galli, E., Zwicky, P., Furrer, R., Peukert, C., Dutertre, C. A., Eglseer, K. M., Ginhoux, F., Flierl-Hecht, A., Kümpfel, T., De Feo, D., Schreiner, B., Mundt, S., Kerschensteiner, M., Hohlfeld, R., Beltrán, E., … Becher, B. (2022). Twin study reveals non-heritable immune perturbations in multiple sclerosis. Nature, 603(7899), 152–158. https://doi.org/10.1038/s41586-022-04419-4 Co-authorship; Mentorship of the PhD student, providing intellectual input for the experimental approach and revised the manuscript

  5. Zwicky, P., Ingelfinger, F., Silva de Melo, B. M., Ruchti, F., Schärli, S., Puertas, N., Lutz, M., Phan, T. S., Kündig, T. M., Levesque, M. P., Maul, J. T., Schlapbach, C., LeibundGut-Landmann, S., Mundt, S. *, & Becher, B. * (2021). IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. Science immunology, 6(64), eabg9012. https://doi.org/10.1126/sciimmunol.abg9012 *Shared last authorship; I conceptualized the study, supervised the PhD student, revised the manuscript and acquired funding

  6. Ingelfinger, F., Krishnarajah, S., Kramer, M., Utz, S. G., Galli, E., Lutz, M., Zwicky, P., Akarca, A. U., Jurado, N. P., Ulutekin, C., Bamert, D., Widmer, C. C., Piccoli, L., Sallusto, F., Núñez, N. G., Marafioti, T., Schneiter, D., Opitz, I., Lanzavecchia, A., Jung, H. H., … Becher, B. (2021). Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature. Acta neuropathologica, 141(6), 901–915. https://doi.org/10.1007/s00401-021-02299-y. Co-authorship; Mentorship of the PhD student, providing intellectual input for the experimental approach and data analysis and revised the manuscript

  7. Mundt, S., Keller, A., & Greter, M. (2021). The dural sinus hub: more than just a brain drain. Cell, 184(4), 858–860. https://doi.org/10.1016/j.cell.2021.01.040

  8. Keller, C. W., Kotur, M. B., Mundt, S., Dokalis, N., Ligeon, L. A., Shah, A. M., Prinz, M., Becher, B., Münz, C., & Lünemann, J. D. (2021). CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation. Autophagy, 17(5), 1244–1258. https://doi.org/10.1080/15548627.2020.1756678 Co-authorship; Performed high-dimensional flow cytometry and data analysis of the steady state brain cDC compartment

  9. Phan, T. S., Schink, L., Mann, J., Merk, V. M., Zwicky, P., Mundt, S., Simon, D., Kulms, D., Abraham, S., Legler, D. F., Noti, M., & Brunner, T. (2021). Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids. Science advances, 7(5), eabe0337. https://doi.org/10.1126/sciadv.abe0337. Co-authorship; Providing intellectual input for the experimental approach and data analysis and revised the manuscript

  10. Mundt, S., Greter, M., Flügel, A., & Becher, B. (2019). The CNS Immune Landscape from the Viewpoint of a T Cell. Trends in neurosciences, 42(10), 667–679. https://doi.org/10.1016/j.tins.2019.07.008. First authorship; I conceptualized and wrote the manuscript

  11. Mundt, S., Mrdjen, D., Utz, S. G., Greter, M., Schreiner, B., & Becher, B. (2019). Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation. Science immunology, 4(31), eaau8380. https://doi.org/10.1126/sciimmunol.aau8380. First authorship; I planned and performed all experiments, analyzed the data and wrote the manuscript

  12. Keller, C. W., Sina, C., Kotur, M. B., Ramelli, G., Mundt, S., Quast, I., Ligeon, L. A., Weber, P., Becher, B., Münz, C., & Lünemann, J. D. (2017). ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11228–E11237. https://doi.org/10.1073/pnas.1713664114. Co-authorship; Performed high-dimensional flow cytometry and data analysis of the steady state brain cDC compartment

  13. Basler, M., Mundt, S., & Groettrup, M. (2018). The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire. European journal of immunology, 48(3), 419–429. https://doi.org/10.1002/eji.201747282

  14. Mundt, S., Basler, M., Sawitzki, B., & Groettrup, M. (2017). No prolongation of skin allograft survival by immunoproteasome inhibition in mice. Molecular immunology, 88, 32–37. https://doi.org/10.1016/j.molimm.2017.05.022

  15. Mundt, S., Basler, M., Buerger, S., Engler, H., & Groettrup, M. (2016). Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice. Scientific reports, 6, 19434. https://doi.org/10.1038/srep19434

  16. Buerger, S., Herrmann, V. L., Mundt, S., Trautwein, N., Groettrup, M., & Basler, M. (2015). The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection. Journal of immunology (Baltimore, Md. : 1950), 195(9), 4106–4116. https://doi.org/10.4049/jimmunol.1500592

  17. Mundt, S., Groettrup, M., & Basler, M. (2015). Analgesia in mice with experimental meningitis reduces pain without altering immune parameters. ALTEX, 32(3), 183–189. https://doi.org/10.14573/altex.1502021

  18. Mundt, S., Engelhardt, B., Kirk, C. J., Groettrup, M., & Basler, M. (2016). Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. European journal of immunology, 46(1), 104–113. https://doi.org/10.1002/eji.201545578

  19. Basler, M., Mundt, S., Bitzer, A., Schmidt, C., & Groettrup, M. (2015). The immunoproteasome: a novel drug target for autoimmune diseases. Clinical and experimental rheumatology, 33(4 Suppl 92), S74–S79.

  20. Basler, M.*, Mundt, S.*, Muchamuel, T.*, Moll, C., Jiang, J., Groettrup, M., & Kirk, C. J. (2014). Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO molecular medicine, 6(2), 226–238. https://doi.org/10.1002/emmm.201303543. *Shared first authorship; I planned and performed experiments, analyzed the data and wrote the manuscript

Contribution to international conferences and workshops
P: poster T: talk

  • World Immune regulation meeting (WIRM), Swiss Institute of Allergy and Asthma Research (SIAF), Davos (Switzerland), 2022 (T)

  • International Congress of Neuroimmunology (ISNI) – virtual 2021

  • MS State of the Art Symposium, Swiss Multiple Sclerosis Society - virtual 2020 (P)

  • Cell Symposia: The Neuro-Immune Axis – Long Beach (USA), 2019 (P)

  • Joint Meeting of the German Society for Immunology (DGfl) and the Italian Society of Immunology, Clinical Immunology and Allergology (SIICA) – Munich (Germany), 2019 (P)

  • International Congress of Neuroimmunology (ISNI) – Brisbane (Australia), 2018 (T)

  • International Symposium on Dendritic Cells - Aachen (Germany), 2018 (P)

  • Salvisberg Symposium on Advances in Neuropathology (SSAN) – Bludenz (Austria), 2017 (T)

  • CRPP Symposium "Heterogeneity of autoimmune diseases" - Zurich (Switzerland), 2017 (P)

  • SFB 969-Symposium "Two Days of Proteostasis in Konstanz" - Konstanz (Germany), 2014 (T)

  • Annual Meeting of the German Society for Immunology – Bonn (Germany), 2014 (T)

  • Lindau Nobel Laureate Meeting – Lindau/ Mainau (Germany), 2014 (P)

  • International Workshop on “Antigen Processing & Presentation“- Philadelphia (USA), 2014 (P)

  • Annual Meeting of the German Society for Immunology - Mainz (Germany), 2013 (P)

  • Swiss MS Researcher Meeting - University of Bern (Switzerland), 2013 (P)


Scientific presentations as invited speaker

  • Data presentation (invited speaker): “Algorithm guided high-dimensional data analysis using R” – Idorsia Pharmaceuticals Ltd, Allschwil (Switzerland), May 2019

  • Lecture (invited speaker): “Characterization of CNS APCs - who tells encephalitogenic T cells they have arrived?” - University of Konstanz (Germany), December 2018