Research

Group leader (SNSF Ambizione 2020)

Neuroimmunology lab, Institute of Experimental Immunology, University of Zurich

Neuroimmunologist dedicated to elucidate homeostatic and pathogenic neuroimmune interactions.

I want to contribute to a deeper understanding of immune-mediated brain disorders and to unravel the impact of CNS/immune cell-crosstalk during disease but, importantly, also in the steady state. My research uses conditional gene targeting, multi-parameter cytometry approaches and high-dimensional computational data mining.

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Publications

  1. Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B. Twin study reveals non-heritable immune perturbations in multiple sclerosis. Nature. 2022 Feb 16. doi: 10.1038/s41586-022-04419-4. Epub ahead of print. PMID: 35173329.

  2. Krishnarajah S, Ingelfinger F, Friebel E, Cansever D, Amorim A, Andreadou M, Bamert D, Litscher G, Lutz M, Mayoux M, Mundt S, Ridder F, Sparano C, Stifter S A, Ulutekin C, Unger S, Vermeer M, Zwicky P, Greter M, Tugues S, Defeo D, Becher B Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice. Nature Aging. Published online 2021.

  3. Zwicky P, Ingelfinger F, Silva de Melo BM, Ruchti F, Schärli S, Puertas N, Lutz M, Phan TS, Kündig TM, Levesque MP, Maul JT, Schlapbach C, LeibundGut-Landmann S, Becher B*, Mundt S* . IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. Sci Immunol. 2021 Oct 22;6(64):eabg9012. doi: 10.1126/sciimmunol.abg9012. Epub 2021 Oct 22. PMID: 34678045. * shared last authorship

  4. Ingelfinger F, Krishnarajah S, Kramer M, Utz SG, Galli E, Lutz M, Zwicky P, Akarca AU, Jurado NP, Ulutekin C, Bamert D, Widmer CC, Piccoli L, Sallusto F, Núñez NG, Marafioti T, Schneiter D, Opitz I, Lanzavecchia A, Jung HH, De Feo D, Mundt S, Schreiner B, Becher B. Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature. Acta Neuropathol. 2021 Jun;141(6):901-915. doi: 10.1007/s00401-021-02299-y. Epub 2021 Mar 28. Erratum in: Acta Neuropathol. 2021 Oct;142(4):789. PMID: 33774709; PMCID: PMC8113175.

  5. Mundt S, Keller A, Greter M. The dural sinus hub: more than just a brain drain. Cell. 2021 Feb 18;184(4):858-860. doi: 10.1016/j.cell.2021.01.040. PMID: 33606985.

  6. Phan TS, Schink L, Mann J, Merk VM, Zwicky P, Mundt S, Simon D, Kulms D, Abraham S, Legler DF, Noti M, Brunner T. Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids. Sci Adv. 2021 Jan 29;7(5):eabe0337. doi: 10.1126/sciadv.abe0337. PMID: 33514551; PMCID: PMC7846173.

  7. Keller CW, Kotur MB, Mundt S, Dokalis N, Ligeon LA, Shah AM, Prinz M, Becher B, Münz C, Lünemann JD. CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation. Autophagy. 2020 May;17(5):1244-1258. doi: 10.1080/15548627.2020.1756678. Epub 2020 May 13. PMID: 32401602; PMCID: PMC8143233.

  8. Mundt S, Greter M, Flügel A, Becher B. The CNS Immune Landscape from the Viewpoint of a T Cell. Trends Neurosci. 2019 Oct;42(10):667-679. doi: 10.1016/j.tins.2019.07.008. Epub 2019 Aug 29. PMID: 31474310.

  9. Mundt S, Mrdjen D, Utz SG, Greter M, Schreiner B, Becher B. Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation. Sci Immunol. 2019 Jan 25;4(31):eaau8380. doi: 10.1126/sciimmunol.aau8380. PMID: 30679199.

  10. Keller CW, Sina C, Kotur MB, Ramelli G, Mundt S, Quast I, Ligeon LA, Weber P, Becher B, Münz C, Lünemann JD. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11228-E11237. doi: 10.1073/pnas.1713664114. Epub 2017 Dec 12. PMID: 29233943; PMCID: PMC5748192.

  11. Basler M, Mundt S, Groettrup M. The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire. Eur J Immunol. 2018 Mar;48(3):419-429. doi: 10.1002/eji.201747282. Epub 2017 Nov 10. PMID: 29067678.

  12. Mundt S, Basler M, Sawitzki B, Groettrup M. No prolongation of skin allograft survival by immunoproteasome inhibition in mice. Mol Immunol. 2017 Aug;88:32-37. doi: 10.1016/j.molimm.2017.05.022. Epub 2017 Jun 2. PMID: 28582644.

  13. Mundt S, Basler M, Buerger S, Engler H, Groettrup M. Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice. Sci Rep. 2016 Jan 18;6:19434. doi: 10.1038/srep19434. PMID: 26776888; PMCID: PMC4726078.

  14. Mundt S, Engelhardt B, Kirk CJ, Groettrup M, Basler M. Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. Eur J Immunol. 2016 Jan;46(1):104-13. doi: 10.1002/eji.201545578. Epub 2015 Nov 2. PMID: 26464284.

  15. Basler M, Mundt S, Bitzer A, Schmidt C, Groettrup M. The immunoproteasome: a novel drug target for autoimmune diseases. Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 92):S74-9. Epub 2015 Oct 12. PMID: 26458097.

  16. Buerger S, Herrmann VL, Mundt S, Trautwein N, Groettrup M, Basler M. The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection. J Immunol. 2015 Nov 1;195(9):4106-16. doi: 10.4049/jimmunol.1500592. Epub 2015 Sep 23. PMID: 26401002.

  17. Mundt S, Groettrup M, Basler M. Analgesia in mice with experimental meningitis reduces pain without altering immune parameters. ALTEX. 2015;32(3):183-9. doi: 10.14573/altex.1502021. Epub 2015 Mar 24. PMID: 25800953.

  18. Basler M, Mundt S, Muchamuel T, Moll C, Jiang J, Groettrup M, Kirk CJ. Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO Mol Med. 2014 Feb;6(2):226-38. doi: 10.1002/emmm.201303543. Epub 2014 Jan 16. PMID: 24399752; PMCID: PMC3927957.* shared first authorship

Contribution to international conferences and workshops

  • 23rd «MS State of the Art Symposium» - Swiss MS Society, Janurary 2021, online conference

  • Neuro-Immune Axis: Reciprocal Regulation in Development, Health, and Disease – Long Beach, CA, USA, September 2019 (poster presentation)

  • II Joint Meeting of the German Society for Immunology (DGfl) and the Italian Society of Immunology, Clinical Immunology and Allergology (SIICA) – Munich, Germany, September 2019 (oral presentation)

  • 14th International Congress of Neuroimmunology (ISNI 2018) – Brisbane (Australia), August 2018 (oral presentation)

  • 15th International Symposium on Dendritic Cells - Aachen (Germany), June 2018 (poster presentation)

  • Immunology retreat (A. Waisman, B. Becher, R. Liblau) – Bonndorf (Germany), May 2018 (oral presentation)

  • SSAN Salvisberg Symposium on Advances in Neuropathology (Prof. Adriano Aguzzi) – Bludenz (Austria), September 2017 (oral presentation)

  • Immunology retreat (A. Waisman, B. Becher, R. Liblau) – Annecy (France), July 2017 (oral presentation)

  • CRPP MS Symposium "Heterogeneity of autoimmune diseases" - University of Zurich (Switzerland), June 2017 (poster presentation)

  • Immunology retreat (A. Waisman, B. Becher, R. Liblau) – Annecy (France), June 2016 (oral presentation)

  • SFB 969-Symposium "Two Days of Proteostasis in Konstanz" - University of Konstanz (Germany), October 2014 (oral presentation)

  • 44th Annual Meeting of the German Society for Immunology – World Conference Center Bonn (Germany), September 2014 (poster presentation)

  • 65th Lindau Nobel Laureate Meeting – Lindau/ Mainau (Germany), July 2014 (poster presentation)

  • 8th International Workshop on “Antigen Processing & Presentation“ - The Academy of Natural Sciences of Drexel University in Philadelphia (USA), June 2014 (poster presentation)

  • 43th Annual Meeting of the German Society for Immunology - Mainz (Germany), September 2013 (poster presentation)

  • Swiss MS Researcher Meeting 2013 - University of Bern (Switzerland), August 2013

  • 5th Student Symposium on Molecular Medicine - Ulm University (Germany), July 2012 (oral presentation)

Scientific presentations as invited speaker

  • Data presentation (invited speaker): “Algorithm guided high-dimensional data analysis using R” – Idorsia Pharmaceuticals Ltd, Allschwil (Switzerland), May 2019

  • Lecture (invited speaker): “Characterization of CNS APCs - who tells encephalitogenic T cells they have arrived?” - University of Konstanz (Germany), December 2018