Sameer Mir, Ph.D

Dr. Sameer Mir is a Postdoctoral Research Fellow at the National Institutes of Health (NIH), Bethesda, USA, specializing in cancer immunotherapy and molecular oncology. With a Ph.D. in Biological Sciences from the Academy of Scientific and Innovative Research (AcSIR), New Delhi, India, Dr. Mir has made significant contributions to cancer research. His work primarily focuses on developing next-generation targeted immunotherapies for malignant mesothelioma and gastrointestinal cancers, including establishing patient-derived xenograft models to explore mesothelin-directed therapies.

Publications

Dr. Mir has authored several impactful publications in high-impact journals, including:

• Clinical and Translational Medicine on CAR-T cell therapy for gastrointestinal carcinomas.

• Studies on breast cancer stem cells and small molecule inhibitors in Journal of Medicinal Chemistry and International Journal of Biological Macromolecules.

• Research on mitochondrial-mediated apoptosis and plant-based anticancer compounds in journals like Scientific Reports and Current Topics in Medicinal Chemistry.

List of Publications:

1.   Qun Jiang, Weiming Yu, James Ma, Mingming Zhao, Jizhong Zou, Sameer Mir, Jingli Zhang, Ronald N.

Germain, Raffit Hassan. Robust differentiation of NK cells from MSLN.CAR-IL-15-engineered human iPSCs

with enhanced anti-tumor efficacy against solid tumors. Science Advances, adt9932, 2025.

2. Sameer Mir, Abhilash Venugopalan, Jingli Zhang, Nishanth Ulhas Nair, Manjistha Sengupta, Manakamana

Khanal, Chaido Stathopoulou, Qun Jiang, Raffit Hassan. Persistence of activated anti-mesothelin hYP218

chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal

carcinomas: Clinical and Translational Medicine, 14:70057, 2024.

3. Sabiyah Akhter, Malik Muzafar Manzoor, Sameer Mir, Tahirah Khaliq, Phalisteen Sultan, Qazi Parvaiz Hassan. Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cells. Medicinal Plant Biology 10.48130/mpb-0024-0021, 2024.

4. Tahirah Khaliq, Malik A Waseem, Sameer Mir, Phalisteen Sultan, Fayaz A Malik, Qazi Parvaiz Hassan. Isolation and characterisation of pharmaceutically versatile molecules from Rumex dentatus and evaluationn of their cytotoxic activity against human cancer cell lines. Natural Product Research 14786419.2022.2092864, 2023.

5. Gazanfar Ahmad, Sameer Ullah Khan, Sameer Mir, Mir Javid Iqbal, Faheem Hyder Pottoo, Neerupma Dhiman et al. Myrica esculenta Buch.-Ham. (ex D. Don): A Review of its Phytochemistry, Pharmacology and Nutritional Potential. Combinatorial Chemistry & High Throughput Screening 2022, pp. 2372 2386(15), 2022.

6. Sameer Ullah Khan, Anup Singh Pathania,…Wadhwa Bhumika, Loveleena Kour Anand, Mir Shahid Maqbool, Sameer Mir, Jaspreet Kour, Vunnam Venkateswarlu, Fayaz Malik. Activation of lysosomal-mediated cell death in the course of autophagy by mTORC1 inhibitor. Scientific Reports 022-07955-1, 2022.

7. Gazanfar Ahmad, Sameer Mir, Loveleena K Anand, Faheem H Pottoo, Neerupma Dhiman, Fayaz Malik, Asif Ali. Myricanol-9-acetate, a novel naturally occurring derivative of myricanol, induces ROS-dependent mitochondrial-mediated Apoptosis in MCF-7 cancer cells. Current Topics in Medicinal Chemistry

2174/51358, 2021.

8. Bhumika Wadhwa, Masroor Paddar, Sameer Khan, Sameer Mir, Philip AClarke, Anna M Grabowska, Devanahalli G Vijay, Fayaz Malik. AKT isoforms have discrete expression in triple negative breast cancers and roles in cisplatin sensitivity. Oncotarget 10; 11:4194, 2020.

9. Mohd Rehan, Shafiullah, Sameer Mir. Structural diversity, natural sources, and pharmacological potential,of plant-based saponins with special focus on anticancer activity: A review. Medicinal chemistry research 10.1007-02600, 2020.

10. Gazanfar Ahmad, Mubashir H Masoodi, Nahida Tabassum, Sameer Mir, Mir Javaid Iqbal. In vivo hepatoprotective potential of extracts obtained from floral spikes of Prunella vulgaris L. Journal of Ayurveda and Integrative Medicine pii/3444, 2020.

11. Parvaiz A Dar, Sameer Mir, Javeed A Bhat, Abid Hamid, Laishram R Singh, Fayaz Malik, Tanveer A Dar. An,anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells. International journal of biological macromolecules. pii/07548, 2019.

12. Umed Singh, Gousia Chashoo,..Thanusha Thatikonda, Promod Sahu, Pankaj Chibber, Vikas Kumar, Sameer Mir, Sonali S Bharate, …Parvinder Pal Singh. Design of novel 3-pyrimidinylazaindole CDK2/9 inhibitors with potent in vitro and in vivo antitumor efficacy in a triple-negative breast cancer model. Journal of Medicinal Chemistry 10.1021/acs.jmedchem.7b00663, 2017.

P A T E N T S G R A N T E D

• Sameer Mir, Shahnawaz Khan…and Fayaz Malik. Composition for treating paclitaxel-resistant breast cancer and method for preparation thereof. International patent publication number WO 2024/105699 A1, https://patentscope.wipo.int,World Intellectual Property Organisation, WIPO, 2024.

B O O K S A N D B O O K C H A P T E R S

• Sameer Mir, Urmilla John, Nawab John Dar. Ethical and Economic Considerations in Small Molecule Therapy, In “Small Molecules in Neurodegeneration,” ISBN: 9781003520610. Year: 2025. Pages: 24-266.

Publisher: CRC Press.

• Ankit Srivastava, Vijay Kumar Yadav, Annapoorni Ammal, Sameer Mir, Nawab John Dar. Exposome Concept in Pesticide Monitoring, In “Pesticide Toxicology and Risk Assessment”, ISBN: 9781003222576. Year: 2024. Pages: 147-166. Publisher: CRC Press.

Awards and Honors

• Best Poster Award at the AIIMS conference on Translational Oncology (2020)

• Multiple national-level research fellowships in India, including NET-JRF, GATE, and ICMR-JRF.

• Visiting Research Fellow at Stem Cell Facility (SCF)-AIIMS, New Delhi (July 2019 to March 2020)

Invited Talks and Presentations

Dr. Mir has delivered oral presentations at various prestigious conferences and workshops, including:

• Workshops on regenerative medicine organized by AIIMS and Indiana University School of Medicine (2020).

• National Conference on Recent Advances in Biological Sciences (NCRABS-2020)’’ organized by the Department of Biosciences JMI University, New Delhi.

He has also presented posters at international events like American Association of Cancer Research, International Congress of Cell Biology and the Society for Ethnopharmacology.

Mentorship and Scientific Community Participation

Dr. Mir has mentored several M.Sc. and M.Pharm students during his academic career and supervised six dissertation projects. At NIH, he participated as a judge for the 2024 Postbac Poster Day and reviewed over 20 research articles for peer-reviewed journals. His memberships include the American Association of Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO).

Workshops and Community Involvement

Dr. Mir has completed advanced training in cancer immunology, genome editing (CRISPR), and flow cytometry. He actively contributes to the scientific community through collaborations and public outreach, including participating in podcasts and sharing insights on platforms like ResearchGate, LinkedIn, and Google Scholar.

Dr. Sameer Mir continues to innovate in cancer immunotherapy, striving to bridge the gap between laboratory research and clinical applications to benefit patients worldwide.