Protein design is of great technological importance and can solve many biomedically relevant challenges. Examples include new therapeutic agents (COVID-19 inhibitors, COVID-19 vaccines, flu inhibitors), nanomaterials (cages, layers, fibers) and sensors.

Are you interested in protein structure and would like to know more about the magic of de novo design? Then you are the perfect candidate!

The workshop is set up as a “crash course” in protein design, highlighting what is possible with current technology. Participants will learn how to build a four-helix bundle protein from scratch (i.e. using only mathematics). At the end of the workshop, they will obtain a sequence for the protein that folds into the designed structure. The basics of Rosetta, parametric backbone design, design of loops and design of side chains will be introduced. Alphafold 2 and it’s uses will also be presented.