Romain Haudecoeur, PhD, HDR

35 • A. Di Maio, H. Olleik, É. Courvoisier-Dezord, S. Guillier, F. Neulat-Ripoll, R. Haudecoeur, J.-M. Bolla, M. Casanova, J.-F. Cavalier, S. Canaan, V. Pique, Y. Charmasson, E. Baydoun, A. Hijazi, J. Perrier, M. Maresca, M. Robin. Design and synthesis of novel amino and acetamidoaurones with antimicrobial activities. Antibiotics 2024, 13, 300. (https://doi.org/10.3390/antibiotics13040300)

34 • A. Beato, R. Haudecoeur, B. Boucherle, M. Peuchmaur. Expanding chemical frontiers: approaches for generating diverse and bioactive natural product-like compounds libraries from extracts. Chem. Eur. J. 2024, 30, e202304166. (https://doi.org/10.1002/chem.202304166)

33 • L. M. Lazinski, M. Beaumet, B. Roulier, R. Gay, G. Royal, M. Maresca, R. Haudecoeur. Design and synthesis of 4-amino-2’,4’-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells. Eur. J. Med. Chem. 2024, 266, 116165. (https://doi.org/10.1016/j.ejmech.2024.116165)

32 • J. Caburet, F. Verdirosa, M. Moretti, B. Roulier, G. Simoncelli, R. Haudecoeur, S. Ghazi, H. Jamet, J.-D. Docquier, B. Boucherle, M. Peuchmaur. Aurones and derivatives as promising New Delhi metallo-β-lactamase (NDM-1) inhibitors. Bioorg. Med. Chem. 2024, 97, 117559. (https://doi.org/10.1016/j.bmc.2023.117559)

31 • M. Beaumet, L. M. Lazinski, M. Maresca, R. Haudecoeur. Catechol-mimicking transition-state analogues as non-oxidizable inhibitors of tyrosinases. Eur. J. Med. Chem. 2023, 259, 115672. (https://doi.org/10.1016/j.ejmech.2023.115672)

30 • B. Roulier, I. Rush, L. M. Lazinski, B. Pérès, H. Olleik, G. Royal, A. Fishman, M. Maresca, R. Haudecoeur. Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells. Eur. J. Med. Chem. 2023, 246, 114972. (https://doi.org/10.1016/j.ejmech.2022.114972)

29 • L. M. Lazinski, G. Royal, M. Robin, M. Maresca, R. Haudecoeur. Bioactive aurones, indanones, and other hemiindigoid scaffolds: medicinal chemistry and photopharmacology perspectives. J. Med. Chem. 2022, 65, 12594–12625. (https://doi.org/10.1021/acs.jmedchem.2c01150)

28 • A. Beato, A. Gori, B. Boucherle, M. Peuchmaur, R. Haudecoeur. β-Carboline as a privileged scaffold for multitarget strategies in Alzheimer’s disease therapy. J. Med. Chem. 2021, 64, 1392–1422. (https://doi.org/10.1021/acs.jmedchem.0c01887)

27 • J.-L. Décout, R. Zelli, W. Zeinyeh, B. Boucherle, R. Haudecoeur. Methods for synthesizing diversely substituted purines. Patent US20210163484A1, 2021. (https://patents.google.com/patent/US20210163484A1/en)

26 • B. Roulier, B. Pérès, R. Haudecoeur. Advances in the design of genuine human tyrosinase inhibitors for targeting melanogenesis and related pigmentations. J. Med. Chem. 2020, 63, 13428–13443. (https://doi.org/10.1021/acs.jmedchem.0c00994)

25 • L. Froux, A. Elbahnsi, B. Boucherle, A. Billet, N. Baatallah, B. Hoffmann, J. Alliot, R. Zelli, W. Zeinyeh, R. Haudecoeur, B. Chevalier, A. Fortuné, S. Mirval, C. Simard, P. Lehn, J.-P. Mornon, A. Hinzpeter, F. Becq, I. Callebaut, J.-L. Décout. Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity. Eur. J. Med. Chem. 2020, 190, 112116. (https://doi.org/10.1016/j.ejmech.2020.112116)

24 • H. Olleik, S. Yahiaoui, B. Roulier, É. Courvoisier-Dezord, J. Perrier, B. Pérès, A. Hijazi, E. Baydoun, J. Raymond, A. Boumendjel, M. Maresca, R. Haudecoeur. Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens. Eur. J. Med. Chem. 2019, 165, 133–141. (https://doi.org/10.1016/j.ejmech.2019.01.022)

23 • I. Callebaut, J.-P. Mornon, J.-L. Décout, F. Becq, P. Lehn, B. Hoffmann, B. Boucherle, R. Haudecoeur, A. Fortuné, C. Boinot, J. Alliot. Compounds for treating cystic fibrosis. Patent US10414768B2, 2019. (https://patents.google.com/patent/US10414768B2/en)

22 • C. Dumontet, G. Beck, F. Gardebien, R. Haudecoeur, D. Mathé, E.-L. Matera, A. Tourette, E. Mattei, J. Esmenjaud, C. Boyère, A. Nurisso, M. Peuchmaur, B. Pérès, G. Bouchaud, A. Magnan, G. Monneret, A. Boumendjel. Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models. Eur. J. Med. Chem. 2018, 158, 405–413. (https://doi.org/10.1016/j.ejmech.2018.09.033)

21 • K.-A. Nguyen, M. Peuchmaur, S. Magnard, R. Haudecoeur, C. Boyère, S. Mounien, I. Benammar, V. Zampieri, S. Igonet, V. Chaptal, A. Jawhari, A. Boumendjel, P. Falson. Glycosyl-substituted dicarboxylates as detergents for the extraction, overstabilization, and crystallization of membrane proteins. Angew. Chem. Int. Ed. 2018, 57, 2948–2952. (https://doi.org/10.1002/anie.201713395)

20 • R. Haudecoeur, M. Peuchmaur, B. Pérès, M. Rome, G. Sotoing Taïwe, A. Boumendjel, B. Boucherle. Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: a review. J. Ethnopharmacol. 2018, 212, 106–136. (https://doi.org/10.1016/j.jep.2017.10.011)

19 • R. Zelli, W. Zeinyeh, R. Haudecoeur, J. Alliot, B. Boucherle, I. Callebaut, J.-L. Décout. A one-pot synthesis of highly functionalized purines. Org. Lett. 2017, 19, 6360–6363. (https://doi.org/10.1021/acs.orglett.7b03209)

18 • B. Boucherle, M. Peuchmaur, A. Boumendjel, R. Haudecoeur. Occurrences, biosynthesis and properties of aurones as high-end evolutionary products. Phytochemistry 2017, 142, 92–111. (https://doi.org/10.1016/j.phytochem.2017.06.017)

17 • R. Haudecoeur, M. Carotti, A. Gouron, M. Maresca, E. Buitrago, R. Hardré, E. Bergantino, H. Jamet, C. Belle, M. Réglier, L. Bubacco, A. Boumendjel. 2-Hydroxypyridine-N-oxide-embedded aurones as potent human tyrosinase inhibitors. ACS Med. Chem. Lett. 2017, 8, 55–60. (https://doi.org/10.1021/acsmedchemlett.6b00369)

16 • E. Buitrago, R. Hardré, R. Haudecoeur, H. Jamet, C. Belle, A. Boumendjel, L. Bubacco, M. Réglier. Are human tyrosinase and related proteins suitable targets for melanoma therapy? Curr. Top. Med. Chem. 2016, 16, 3033–3047. (https://doi.org/10.2174/1568026616666160216160112)

15 • B. Boucherle, R. Haudecoeur, E. Ferreira Queiroz, M. De Waard, J.-L. Wolfender, R. J. Robins, A. Boumendjel. Nauclea latifolia: biological activity and alkaloid phytochemistry of a West African tree. Nat. Prod. Rep. 2016, 33, 1034–1043. (https://doi.org/10.1039/C6NP00039H)

14 • E. Markova, M. Kotik, A. Krenkova, P. Man, R. Haudecoeur, A. Boumendjel, R. Hardré, Y. Mekmouche, É. Courvoisier-Dezord, M. Réglier, L. Martinkova. Recombinant tyrosinase from Polyporus arcularius: Overproduction in Escherichia coli, characterization and use in a study of aurones as tyrosinase effectors. J. Agric. Food Chem. 2016, 64, 2925–2931. (https://doi.org/10.1021/acs.jafc.6b00286)

13 • A. Laguerre, M. Levillain, L. Stefan, R. Haudecoeur, F. Katranji, M. Pirrotta, D. Monchaud. Synthetic G-quartet as versatile nanotools for the luminescent detection of G-quadruplexes. Chimia 2015, 69, 530–536. (https://doi.org/10.2533/chimia.2015.530)

12 • F. Lecerf-Schmidt, R. Haudecoeur, B. Pérès, M. Marçal Ferreira Queiroz, L. Marcourt, S. Challal, E. Ferreira Queiroz, G. Sotoing Taiwe, T. Lomberget, M. Le Borgne, J.-L. Wolfender, M. De Waard, R. J. Robins, A. Boumendjel. Biomimetic synthesis of Tramadol. Chem. Commun. 2015, 51, 14451–14453. (https://doi.org/10.1039/C5CC05948H)

11 • R. Haudecoeur, A. Gouron, C. Dubois, H. Jamet, M. Lightbody, R. Hardré, A. Milet, E. Bergantino, L. Bubacco, C. Belle, M. Réglier, A. Boumendjel. Investigation of binding-site homology between mushroom and bacterial tyrosinases by using aurones as effectors. ChemBioChem 2014, 15, 1325–1333. (https://doi.org/10.1002/cbic.201402003)

10 • A. Meguellati, A. Ahmed-Belkacem, W. Yi, R. Haudecoeur, M. Crouillère, R. Brillet, J.-M. Pawlotsky, A. Boumendjel, M. Peuchmaur. B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. Eur. J. Med. Chem. 2014, 80, 579–592. (https://doi.org/10.1016/j.ejmech.2014.04.005)

09 • A. Boumendjel, G. Sotoing Taïwe, E. Ngo Bum, T. Chabrol, C. Beney, V. Sinniger, R. Haudecoeur, L. Marcourt, S. Challal, E. Ferreira Queiroz, F. Souard, M. Le Borgne, T. Lomberget, A. Depaulis, C. Lavaud, R. J. Robins, J.-L. Wolfender, B. Bonaz, M. De Waard. Occurrence of the synthetic analgesic tramadol in an African medicinal plant. Angew. Chem. Int. Ed. 2013, 52, 11780–11784. (https://doi.org/10.1002/anie.201305697)

08 • R. Haudecoeur, M. Peuchmaur, A. Ahmed-Belkacem, J.-M. Pawlotsky, A. Boumendjel. Structure-activity relationships in the development of allosteric hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: Ten years of research. Med. Res. Rev. 2013, 33, 934–984. (https://doi.org/10.1002/med.21271)

07 • R. Haudecoeur, L. Stefan, D. Monchaud. Multitasking water-soluble synthetic G-quartets: From preferential RNA-quadruplex interaction to biocatalytic activity. Chem. Eur. J. 2013, 19, 12739–12747. (https://doi.org/10.1002/chem.201300791)

06 • R. Haudecoeur, L. Stefan, F. Denat, D. Monchaud. A model of smart G-quadruplex ligand. J. Am. Chem. Soc. 2013, 135, 550–553. (https://doi.org/10.1021/ja310056y)

05 • H.-J. Xu, L. Stefan, R. Haudecoeur, S. Vuong, P. Richard, F. Denat, J.-M. Barbe, C. P. Gros, D. Monchaud. Porphyrin-templated synthetic G-quartet (PorphySQ): A second prototype of G-quartet-based G-quadruplex ligand. Org. Biomol. Chem. 2012, 10, 5212–5218. (https://doi.org/10.1039/C2OB25601K)

04 • R. Haudecoeur, A. Boumendjel. Recent advances in the medicinal chemistry of aurones. Curr. Med. Chem. 2012, 19, 2861–2875. (https://doi.org/10.2174/092986712800672085)

03 • C. Dubois, R. Haudecoeur, M. Orio, C. Belle, C. Bochot, A. Boumendjel, R. Hardré, H. Jamet, M. Réglier. Versatile effect of aurone structure on mushroom tyrosinase activity. ChemBioChem 2012, 13, 559–565. (https://doi.org/10.1002/cbic.201100716)

02 • R. Haudecoeur, A. Ahmed-Belkacem, W. Yi, A. Fortuné, R. Brillet, C. Belle, E. Nicolle, C. Pallier, J.-M. Pawlotsky, A. Boumendjel. Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J. Med. Chem. 2011, 54, 5395–5402. (https://doi.org/10.1021/jm200242p)

01 • W. Yi, C. Dubois, S. Yahiaoui, R. Haudecoeur, C. Belle, H. Song, R. Hardré, M. Réglier, A. Boumendjel. Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase. Eur. J. Med. Chem. 2011, 46, 4330–4335. (https://doi.org/10.1016/j.ejmech.2011.07.003)