王永樑教授

實驗室網頁

Robert YL Wang

歡迎加入王永樑教授研究室 (長庚大學第一醫學大樓 10 樓 B 區)

現職：

長庚大學生物醫學系教授

長庚大學生物科技產業博士學位學程教授

長庚大學技術合作處執行秘書

長庚大學技術移轉中心主任

歡迎加入分子病毒研究室

本實驗室具有三大特色：

(1) 基礎病毒學研究。

(2) 執行經濟部生技產業創新服務計畫。

(3) 與生技廠商直接合作的項目，包括：技術服務、產品研發。

(4) 與林口長庚醫院共同執行: (a) EV 71病毒檢測 (b) 微小RNA與病毒檢測 (c) BKV與腎/肝臟移植後病人的關係。

發表文獻 (僅列出 2020-2024)

1) 1) Cheng CH, Yatsuda H, Chen HH, Young GH, Liu SH, Wang RY* (corresponding author) (2024) Tracking the risk of cardiovascular disease after almond and oat milk intervene or statin medication with a powerful reflex SH-SAW POCT platform. Sensors 24, 6517. https://doi.org/10.3390/s24206517. (SCI, impact factor: 3.4)

2) Ding C, Jiao Y, Li Y, Shen L, Zhang W, Ma H, Han L, Zhang Z, Yan F, Mei Y, Wang RY* (corresponding author), Yang J (2024) A novel pH-responsive multi-component nanodelivery system with siRNA for plant disease management. Chem. Eng. J. 497, 155001. (SCI, impact factor: 13.3).

3) Lin CJ, Hwang TL, Wang RY, Nain Amit, Shih RH, Chang L, Lin HJ, Harroun SG, Chang HT, Huang CC (2024) Augmenting neutrophil extracellular traps with carbonized polymer dots: a potential treatment for bacterial sepsis. Small; DOI: 10.1002/smll.202307210 (SCI, impact factor: 13.0)

4) Chou TH, Cheng CH, Lo CJ, Young GH, Liu SH, Wang RY*(corresponding author) (2024) New advnaces in rapid pretreatment for small dense LDL cholesterol measurement using Shear Horizontal Surface Acoustic Wave (SH-SAW) technology. International Journal of Molecular Sciences. 25:1044. (SCI, impact factor: 4.9)

5) Tan YW, Teo FMS, Ler SG, Alli-Shaik A, Nyo M, Chong CY, Tan WH, Wang RY*(corresponding author) Gunaratne J, Chu JH (2023) Potential relevance of salivary legumain for the clinical diagnostic of hand, foot, and mouth disease. J. Medical Virology 95: e29243. (SCI, impact factor: 6.8)

6) Xu P, Xu H, Kuo CY, Chen HH, Wang RY*(corresponding author) (2023) The Upf1 protein restricts EV-A71 viral replication. Microbes and Infection 25, 105220. (SCI, impact factor: 2.6)

7) Wang JW, Li YJ, Wu HH, Hsu HH, Chang MY, Wang RY* (corresponding author), Tian YC (2023) The essential role of the ERK activation in large T antigen of BK polyomavirus regulated cell migration. Virus Research 336, 199220. (SCI, impact factor: 2.5)

8) Cheng CH, Yatsuda H, Goto M, Kondoh J, Liu SH, Wang RY* (corresponding author) (2023) Application of shear horizontal surface acoustic wave (SH-SAW) immunosensor in point-of-care diagnosis. Biosensors. 13, 605. (SCI, impact factor: 4.9).

9) Lin HY, Luo KL, Mao JY, Lin CJ, Wang CY, Panny L, Chen SY, Lin SC, Huang CC, Harroun S, Wang RY, Wu CJ (2023) In situ derived sulfated/sulfonated carbon nanogels with multi-protective effects against influenza A virus. Chem. Eng. J. 485, 141429. (SCI, impact factor: 13.3).

10) Cheng CH, Peng YC, Lin SM, Yatsuda H, Liu SH, Liu SJ, Kuo CY, Wang RY* (corresponding author) (2022) Measurements of anti-SARS-CoV-2 antibody levels after vaccination using a SH-SAW biosensor. Biosensors. 12, 599. (SCI, impact factor: 4.9).

11) Chen HH, Lin CJ, Anand A, Lin HJ, Lin HY, Mao JY, Wang PH, Tseng YJ, Tzou WS, Huang CC, Wang RY* (corresponding author) (2022) Development of antiviral carbon quantum dots that target the Japanese encephalitis virus envelope protein. J Biol Chem. 298(6): 101957. (SCI, impact factor: 4.0).

12) Liu S, Dong Y, Wang Y, Hu P, Wang J, Wang RY* (corresponding author) (2021) Pristimerin exerts antitumor activity against MDA-MB-231 triple-negative breast cancer cells by reversing of epithelial-mesenchymal transition via downregulation of integrin b3. Biomedical J. 44: S84-S92. (SCI, impact factor: 4.1)

13) Peng YC, Cheng CH, Yatsuda H, Liu SH, Liu SJ, Kogai T, Kuo CY, Wang RY*(corresponding author) (2021) A Novel Rapid Test to Detect Anti-SARS-CoV-2 N Protein IgG Based on Shear Horizontal Surface Acoustic Wave (SH-SAW). Diagnostics 11:1838 (SCI, impact factor: 3.0)

14) Li YJ, Wu HH, Chen CH, Wang HH, Chiang YJ, Hsu HH, Pang ST, Wang RY, Tian YC (2021) High Incidence and Early Onset of Urinary Tract Cancers in Patients with BK Polyomavirus Associated Nephropathy. Viruses; 13: 476 (SCI, impact factor: 3.8)

15) Liao T, Wang Xi, Donolato M, Cruz MM, Balmaseda A, Harris E, Wang RY*(corresponding author) (2020) Evaluation of ViroTrack Sero Zika IgG/IgM, a new rapid and quantitative Zika serological diagnostic assay. Diagnostics 10:372; doi:10.3390 (SCI, impact factor: 3.0)

16) Xu P, Xu H, Cheng HS, Chan HH, Wang RY*(corresponding author) (2020) MicroRNA 876-5p modulates EV-A71 replication through downregulation of host antiviral factors. Virology Journal; 17:21 (SCI, impact factor: 4.0)

17) Lai MC, Chen HH, Xu P, Wang RY*(corresponding author) (2020) Translational control of Enterovirus A71 gene expression. Journal of Biomedical Science; 27:22 (SCI, impact factor: 9.0)

實驗室成員：

博士後研究員：陳翰翔博士

研究助理：徐晏涵、蘇恆毅

博士班：周台華、理昱博、彭傳凱、李龢云、廖麗娟、詹惠婷

碩士班：張哲誠

Dr. Ahlquist work on many different viruses, including plant virus, Brome mosaic virus (BMV). I need to mention that BMV was the first plant RNA virus for which designed infectious transcripts were engineered from cloned viral cDNA. This allowed recombinant DNA manipulation of the viral genome for mechanistic studies and other goals, and has since been used in vitro and in vivo for reverse genetics of many other RNA viruses. The other important thing is that Dr. Ahlquist demonstrated that BMV proteins direct virus-specific RNA replication, transcription, encapsidation and recombination in the genetic model yeast. It opened a door for “system biology studies”. Using different host model to study viral and host functions in many infection processes.

Another notable contribution from Paul’s group is working on tumor viruses: Hepatitis B virus and retroviruses and a major DNA tumor virus, human papillomavirus. Dr. Ahlquist also conducted the first genome-wide analysis of host factors in Influenza virus replication, again, this is a pioneer study for virus-host interaction.

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