Improvements of Vaginal Atrophy without Systemic Side Effects after Topical Application of Pueraria mirifica, a Phytoestrogen-rich Herb, in Postmenopausal Cynomolgus Macaques

The estrogenic efficacy of topical vaginal application of Pueraria mirifica extract (PM) on the restoration of vaginal atrophy. Topical vaginal treatment with PM stimulated the maturation of the vaginal epithelium without causing systemic side effects in postmenopausal monkeys. The implication is that PM could be a safer alternative to treat vaginal atrophy in postmenopausal women.

Together with vaginal atrophy, a decrease in vaginal secretion and increase in vaginal pH also occurs, which leads to an increased incidence of vaginitis, vaginal dryness, itching, burning and irritation . Most vaginal atrophic patients complain of dyspareunia during sexual intercourse. Conjugated equine estrogens (CEE) cream, which contained a mixture of estrone, equilin, 17β-dihydroequilin,17α-estradiol and 17α-dihydroequilin at 0.625 mg/g cream, is currently the most common choice of vaginal product for the treatment of vaginal atrophy. However, the reported side effects of CEE cream include an increased occurrence of endometrial hyperplasia, endometrial stimulation, breast tenderness and uterine bleeding . Therefore, the use of synthetic phytoestrogens or an extract of phytoestrogen containing plants for the treatment of vaginal atrophy has become attractive as a potentially safer alternative . Pueraria mirifica (PM) is an endemic herb of Thailand, and its tuberous root contains a high amount of phytoestrogens.

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