Method: Animals exposed to stress were treated either 1 h or 7 days later with alprazolam or vehicle for 3-days. Outcome measures included behavior in the elevated plus-maze (EPM) and acoustic startle response (ASR) tests 30 days after initial exposure and freezing behavior upon exposure to a trauma-cue on day 31. One group was repeatedly exposed to the triggering trauma shortly before and after treatment and assessed as above. Circulating corticosterone levels were assessed 4 h after initiation of alprazolam and post-treatment. Pre-set cut-off behavioral criteria classified exposed animals according to their EPM and ASR response-patterns into 'extreme', 'minimal,' or 'partial' behavioral response for analysis of prevalence rates.
Conclusion: A brief course of alprazolam in the immediate aftermath of stress-exposure is associated with less favorable responses to additional stress-exposure later on. Alprazolam was associated with a significant attenuation of the HPA-response, suggesting a possible link between initial HPA-axis response disruption and the subsequent unfavorable outcomes.
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He was still trembling when he reached the street, but a walkdown the Rue Bonaparte to the quais set him up, and as he crossedthe Seine, fresh and new by the quai lamps, he felt exultant. Butback in his room he couldn't sleep. The image of Helen hauntedhim. Helen whom he had loved so until they had senselessly begunto abuse each other's love, tear it into shreds. On that terribleFebruary night that Marion remembered so vividly, a slow quarrelhad gone on for hours. There was a scene at the Florida, and thenhe attempted to take her home, and then she kissed young Webb ata table; after that there was what she had hysterically said.When he arrived home alone he turned the key in the lock in wildanger. How could he know she would arrive an hour later alone,that there would be a snowstorm in which she wandered about inslippers, too confused to find a taxi? Then the aftermath, herescaping pneumonia by a miracle, and all the attendant horror.They were "reconciled," but that was the beginning of the end,and Marion, who had seen with her own eyes and who imagined it tobe one of many scenes from her sister's martyrdom, neverforgot.
Moments later, standing safely inside a bowling alley with her best friend, she hears a sound like thunder. With one devastating explosion, the town is changed forever. In the next few days, four lives become entwined, as the townspeople face sudden loss and new, unpredictable realities. Set against the backdrop of the Civil Rights Movement and the escalating Vietnam War, Centerville forms an engrossing meditation on the complex questions that arise in the wake of senseless violence. be457b7860
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