Ovarian Cancer Cell Line Data Portal
For more information, please read the published paper:
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Platinum-based chemotherapies are widely used anti-cancer drugs. Tumor resistance to platinum compounds is a major determinant of patient survival, including in high grade serous ovarian cancer (HGSOC). To understand mechanisms of platinum resistance and identify potential therapeutic targets in resistant HGSOC, we generated a comprehensive, reproducible data resource comprised of dynamic (+/-carboplatin) proteomic/posttranslational modification and RNASeq profiles from HGSOC intra-patient cell line pairs derived from 3 patients before and after acquiring platinum resistance.
Time course visualization of RNA, protein, and PTM relative abundance of individual genes in 3 ovarian cancer cell line pairs and 20 PDX models.
This interactive data portal supports query, visualization, and downloads of multi-omics data from a comprehensive proteogenomic study of platinum refractoriness in high-grade serous ovarian cancers, a collaborative project by Clinical Proteomic Tumor Analysis Consortium (CPTAC).
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