Research Topic

We are interested in biochemical regulatory mechanisms and their physiological implications in the Ubiquitin-Proteasome System. UPS is responsible for the degradation of most of intracellular proteins. Based on our understanding through various experimental methods in biochemistry, molecular biology, cell biology, and chemical biology we are exploring a possibility of modulating the system using pharmacological intervention. Our ultimate goal is to develop a therapeutic, mechanism-modifying drug of various human diseases focusing on neurodegenerative diseases.

Ongoing Projects

∙ Identifying novel proteasome activity regulators and understanding their biochemical functions

∙ Understanding the ubiquitin-proteasome system's physiological implication in Alzheimer's diseases and other human diseases

∙ Developing new chemical biological methods to understand and modulate proteotoxic protein degradation and aggregations

∙ Characterizing the proteasome dynamics in human pathophysiology and applying the knowledge into therapeutic intervention.