STAR
STereoselective environmental processes in Antibiotics: role for Resistance
STereoselective environmental processes in Antibiotics: role for Resistance
Project Description
STAR aims to deepen the current knowledge about antibiotic resistance, by addressing an important topic that has been neglected: the fundamental understanding of enantioselectivity of environmental processes that can impact the fate and behaviour of pharmaceutical contaminants. The project is led by the R&D unit Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials (LSRE-LCM), Associate Laboratory in Chemical Engineering (ALiCE), Faculty of Engineering, University of Porto (FEUP), in partnership with Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE/ALiCE/FEUP). The partner institutions are the One Health Toxicology Research Unit (1H-TOXRUN), University Institute of Health Sciences, CESPU, the Faculty of Pharmacy of the University of Porto (FFUP), and the Portuguese Catholic University. Moreover, the project counts with the support from a collaborative institution, Aquapor Serviços S.A.
Development of Enantioselective analytical methods.
Semi-preparative enantioseparation and assignment of absolute configuration.
Enantiomeric profiling of antibiotics and metabolites and analysis of ARB and ARGs.
Enantioselective biotransformation of mixtures of antibiotics and metabolites.
Dissemination, networking, and management.