老師個人檔案 PI Profile

Joseph, Ta-Chien Tseng (曾大千)

Professor

Precision Medicine Ph.D. Program

  College of Life Science and Medicine, National Tsing Hua University.

Tel: 886-3-5742756 Email: tc.tseng@mx.nthu.edu.tw

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•  EDUCATION

  • 1991-1998   Ph.D. Department of Life Science, Molecular and Cellular Biology Unit,
    National Tsing-Hua University, Taiwan. 

  • 1985-1989      B.S. Department of Electrical and Control Engineering, 

                        National Chiao-Tung University, Taiwan. 

• FIELDS OF SPECIALITY

  • Bioinformatics, Genotyping, Next generation sequencing, translational regulation, Molecular Biology, Colorectal Cancer, Exosome, Liquid Biopsy

• EXPERIENCE

  • 2024-Present   Director, Institute of Biotechnology, College of Life Science and Medicine,
    National Tsing Hua University. 

  • 2023-Present   Professor, Precision Medicine Ph.D. Program, College of Life Science and Medicine,
    National Tsing Hua University. 

  • 2022-2023 Professor, Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology,
    National Cheng-Kung University  

• 2018-2023   Director, Center for Precision Biomedicine Research,
  National Cheng-Kung University

• 2014-Present   Scientific Consultant, Insight Genomics Inc.

• 2012-2023   Deputy Director, Center for Genomic Medicine,
  National Cheng-Kung University   

• 2011-2022   Associated Professor, Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology,
  National Cheng-Kung University 

• 2008-2011   Assistant Professor, Institute of Bioinformatics, College of Bioscience and Biotechnology,
  National Cheng-Kung University 

• 2003-2008  Research Assistant Professor, Program for promoting academic excellence of university, Department of Pharmacology,
  National Cheng-Kung University

• 2000-2002   R&D Associated Director, AsiaGen Corporation

• 1999-2000   Postdoctoral Fellow, Department of Biomedical Research,
  St. Elizabeth’s Medical Center of Boston, Massachusetts, USA.

• MAJOR AWARD and HONORS

  • 2022 Future Tech Award, National Science Council, Taiwan

  • 2017 Excellent Tutoring Teacher Award, NCKU

  • 2012 Excellent Tutoring Teacher Award, NCKU

• RESEARCH INTERESTS

  • Precision medicine, Developing genetic testing reagent, Prediction of disease risk based on genotyping data. 

  • Study the translational regulation mechanism of CRC (colorectal cancer).

• PUBLICATIONS 

1. Yang TH, Chiang YH, Shiue SC, Lin PH, Yang YC, Tu KC, Tseng YY, Tseng JT*, Wu WS. Cancer DEIso: An integrative analysis platform for investigating differentially expressed gene-level and isoform-level human cancer markers. Comput Struct Biotechnol J. 2021 Sep 8;19:5149-5159

2. Wu WS, Tsao YH, Shiue SC, Chen TY, Tseng YY, Tseng JT*. A tool for analyzing and visualizing ribo-seq data at the isoform level. BMC Bioinformatics. 2021 May 25;22(Suppl 10):271.

3. Lin CC, Wu CY, Tseng JT, Hung CH, Wu SY, Huang YT, Chang WY, Su PL, Su WC. Extracellular Vesicle miR-200c Enhances Gefitinib Sensitivity in Heterogeneous EGFR-Mutant NSCLC. Biomedicines. 2021 Feb 28;9(3):243.

4. Huang WY, Chen DR, Kor CT, Chen TY, Lin PT, Tseng JTC, Wu HM. Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women. Metabolites. 2020 Oct 19;10(10):420.

5. Lin YH, Hung SJ, Chen YL, Lin CH, Kung TF, Yeh YC, Tseng JT*, Liu T*. Dissecting efficiency of a 5' rapid amplification of cDNA ends (5'-RACE) approach for profiling T-cell receptor beta repertoire. PLoS One. 2020 Jul 23;15(7): e0236366.

6. Chan YL, Lai WC, Chen JS, Tseng JT, Chuang PC, Jou J, Lee CT, Sun HS. TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis. Cancers (Basel). 2020 Jul 8;12(7):1844.

7. Zhang Y, Tseng JT, Lien IC, Li F, Wu W, Li H. mRNAsi Index: Machine Learning in Mining Lung Adenocarcinoma Stem Cell Biomarkers. Genes (Basel). 2020 Feb 27;11(3):257 

8. Wu WS, Jiang YX, Chang JW, Chu YH, Chiu YH, Tsao YH, Nordling TEM, Tseng YY, Tseng JT.* HRPDviewer: human ribosome profiling data viewer. Database (Oxford). 2018 Jan 1; 2018:bay074.

9. Wu WS, Tu BW, Chen TT, Hou SW, Tseng JT. (2017) CSmiRTar: Condition-Specific microRNA targets database. PLoS One. 12(7):e0181231

10. Lin GL, Ting HJ, Tseng TC, Juang V, Lo YL. (2017) Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PLoS One. 2017 12(10):e0185625. 

• PATENTS

1. Hung; Liang-Yi, Lai; Chien-Hsien, Tseng; Ta-Chien, Lee; Jeng-Chang, Lin; Bo-Wen (2019) SHORT INTERFERING RNA FOR TREATING CANCER United States Patent No. 10174322 B2

2. 曾大千；林祐宏；蔡松霖；林偉盟；洪晨瑋；江淑華 (2021) 核苷酸多型性親緣鑑定方法
   中華民國 發明第I747158號 專利期限：2021/11/21-2040/02/11 

3. 洪良宜, 曾大千, 賴謙賢, 李政昌, 林博文 (2017) 用以治療癌症之短干擾核糖核酸分子
   中華民國 發明第I585204號 專利期限：2017/06/01-2036/02/23