In the spring of 1621, the English settlers of Plymouth came face to face with Wampanoag Indians. The very first was a warrior named Samoset, then Squanto, and shortly after Massasoit and his tribe.
You have several options concerning your relationship with the Indians.
They have what you need. Survival skills, provisions, and knowledge of the geography and it's hazards. For that reason it may be a good idea to attempt to befriend them. If so, how friendly should you be. Do you want them living in your fort? Do you want them at you festivals?
As far you you know these Indians are hostile to you. But you have the weapon technology to rid yourselves of them. Should you use it?