A proposed device to induce ovulation and increase pregnancy rate for individuals with PCOS
By: Ritika Nayak, Ashley Guzman, Amrita Randhawa
Poly Cystic Ovarian Syndrome (PCOS) is essentially a condition that affects women's hormone levels in the body-specifically the imbalance of hormones. In regular functioning ovaries, an egg is made and released monthly which results in a period. In PCOS however, the egg is not properly made or not released at all. Only people who have ovaries can develop PCOS. Women of all races and ethnicities can be at risk. PCOS is however mostly genetic and can be passed down from mother or father. 5-10% of women that are between the ages of reproduction (15-44 years of age) develop PCOS. 5 million women have PCOS in the US, and it is estimated that up to 26% of individuals have PCOS worldwide. There are more than 200,000 cases per year. There is no current all inclusive treatment because PCOS is determined to be a case-by-case syndrome.
Women with PCOS have higher levels of androgens than normal, which causes brain signal interference. This interference causes the hormone levels of luteinizing hormone, the hormone that stimulates the ovaries to release the eggs during menstruation, to drop lower than normal. The lack of ovulation causes the fluid filled follicles to grow and form cysts on the ovaries. The abundance of androgens leads to extra hair growth and acne in individuals with PCOS. Another hormone imbalance caused by PCOS is high levels of insulin. The copious amounts of insulin can lead to diabetes in many people. People with PCOS are also more likely to have high blood pressure, high levels of LDL cholesterol, sleep apnea, depression and anxiety, and endometrial cancer.
Common Symptoms
Level of androgens increase (male hormone that has testeosterone)
Insulin resistance causes glucose buildup in the bloodstreams
Androgens also increase oil production of skin
Hormonal imbalance prevents egg from being released properly
Diagnosis of PCOS
Blood test: Detects hormone levels in the body, androgen excess in the body, and glucose tolerance
Pelvic Exam: Doctor inspects reproductive organs for abnormalities, masses and growths
Transvaginal Ultrasound: Observe thickness of the lining of the uterus. Transducer placed in the vagina and emits sound waves which are then translated into images on the computer screen
Pelvic Exam
Transvaginal Ultrasound
Blood Test
Currently Used Methods for Symptom Relief/ Birth Control Methods
Many women have seen a great reduction in symptoms and for some, all symptoms of PCOS are alleviated using the medication listed below.
Most common form of symptom relief, Regulates hormone imbalances by increasing Estrogen levels. Induces ovulation. They are commonly known as "The Pill" and is taken like normal birth control. 21 days of active pills and 7 days of placebo pills.
Cons: Higher risk of CardioVascular issues, Higher Risk of Diabetes, Weight Gain
A ring worn inside the vagina, releases estrogen and progestin. Method is 91% effective, and induces ovulation. Leave it in for 21 days and remove for seven.
Cons: Spotty periods, Nausea, Increased Vaginal Discharge, and Mood Changes
Device is inserted in the cervix. Works for long term and does not need to be monitored daily. Releases progestin which induces ovulation.
Cons: Not ideal because progestin causes water weight which results in weight gain
Relieves insulin resistance, contributes to weight loss, and improves fertility rate. Is taken orally and starts off at 500 mg once daily, then twice daily after a week and then 3 times after another week and continuing this dosage perpetually.
Cons: Can cause a lot of pain, vommiting, and bloating
These methods vary from relieving symptoms while acting as birth control, to increasing chances of fertility for people wishing to conceive. The prescription and type of method used will depend on the individual's needs and may change over the course of their lifetime. None of these methods are free from severe side effects which include leaving the user at higher risk of blood clots. Also progestin used in these method can mimic androgen which is bad for PCOS.