"how cancer cell-ECM interaction stimulates cancer-promoting phenotypes"

Publications

Pubmed: https://www.ncbi.nlm.nih.gov/myncbi/1J1SYp6yltz5z/bibliography/public/

Google Scholar: https://scholar.google.com/citations?user=ImJYHnkAAAAJ&hl=en

13. Park J*, Kim DH*, Shah SR, Kim HN, Kshitiz, Kim P, Quiñones-Hinojosa A, Levchenko A. Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and small Rho-family GTPases. Nat. Commun. 2019 Jun 27; 10:2797.

12. Kim DH, Ewald AJ, Park J, Kshitiz, Kwak MK, Gray RS, Su CY, Seo J, An SS, Levchenko A. Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread. Sci. Rep. 2018 Sep 29; 8:14210.

11. Park J, Kim DH, Levchenko A. Topotaxis: a new mechanism of directed cell migration in topographic ECM gradients. Biophys J. 2018 Mar 27; 114(6):1257-1263. doi: 10.1016/j.bpj.2017.11.3813. Review.

10. Park J, Holmes WR, Lee SH, Kim HN, Kim DH, Kwak MK, Wang CJ, Edelstein-Keshet L, Levchenko A. Mechanochemical feedback underlies coexistence of qualitatively distinct cell polarity patterns within diverse cell populations. Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28):E5750-E5759. Epub 2017 Jun 27.

9. Nishimura S, Mishra-Gorur K, Park J, Surovtseva YV, Sebti SM, Levchenko A, Louvi A, Gunel M. Combined HMG-COA reductase and prenylation inhibition in treatment of CCM. Proc Natl Acad Sci U S A. 2017 May 23; 114(21):5503-5508.

8. Holmes WR, Park J, Levchenko A, Edelstein-Keshet L. A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns. PLoS Comput Biol. 2017 May; 13(5):e1005524.

7. Shah SR, Tippens N, Park J, Mohyeldin A, Vela G, Martinez-Gutierrez JC, Margolis SS, Schmidt S, Levchenko A, Quinones-Hinojosa A. 217 YAP is ready to Rac and Rho: Elucidation of a novel YAP-driven network that potentiates brain cancer cell dispersal and confers poor survival in patients. Neurosurgery. 2016 Aug; 63 Suppl 1:185.

6. Park J, Kim DH, Kim HN, Wang CJ, Kwak MK, Hur E, Suh KY, An SS, Levchenko A. Directed migration of cancer cells guided by the graded texture of the underlying matrix. Nat Mater. 2016 Jul; 15(7):792-801.

5. Smith CL, Kilic O, Schiapparelli P, Guerrero-Cazares H, Kim DH, Sedora-Roman NI, Gupta S, O'Donnell T, Chaichana KL, Rodriguez FJ, Abbadi S, Park J, Quiñones-Hinojosa A, Levchenko A. Migration phenotype of brain-cancer cells predicts patient outcomes. Cell Rep. 2016 Jun 21; 15(12):2616-24.

4. Molitoris JM, Paliwal S, Sekar RB, Blake R, Park J, Trayanova NA, Tung L, Levchenko A. Precisely parameterized experimental and computational models of tissue organization. Integr Biol (Camb). 2016 Feb; 8(2):230-42.

3. Howard JD, Moriarty WF, Park J, Riedy K, Panova IP, Chung CH, Suh KY, Levchenko A, Alani RM. Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration. Pigment Cell Melanoma Res. 2013 Sep; 26(5):697-707.

2. Kshitiz, Park J, Kim P, Helen W, Engler AJ, Levchenko A, Kim DH. Control of stem cell fate and function by engineering physical microenvironments. Integr Biol (Camb). 2012 Sep; 4(9):1008-18.

1. Park J, Kim HN, Kim DH, Levchenko A, Suh KY. Quantitative analysis of the combined effect of substrate rigidity and topographic guidance on cell morphology. IEEE Trans Nanobioscience. 2012 Mar; 11(1):28-36