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Such a disease causes substantial distress or impairment. Signs of this disease include a strong urge to utilize opioids, higher tolerance to opioids, difficulty fulfilling responsibilities, difficulty reducing utilization, and withdrawal symptoms along with discontinuation. Opioid withdrawal symptoms may include nausea, muscle aches, nausea, difficulty sleeping, agitation, and also a very low mood. Dependence and alcohol are elements of a substance use disorder. Complications could include opioid overdose, suicide, HIV/AIDS, hepatitis C, and difficulties in school, work, or house.

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Opioid use disorder (OUD) is a substance use disorder having to do with the use of an opioid. Such a disorder causes significant distress or impairment. Signs of the disease include a strong desire to utilize opioids, higher tolerance to opioids, difficulty fulfilling obligations, trouble reducing use, and withdrawal symptoms along with discontinuation. Opioid withdrawal symptoms may include nausea, muscle aches, diarrhea, difficulty sleeping, agitation, and a low mood. Dependence and alcohol are elements of a substance use disorder.