This page is the virtual booth for the Open Ephys x Miniscope booth (#1766) at SfN 2019. Here you can find an overview of what we're showing at our booth. To find out more about what we're up to during and after the meeting, follow us on Twitter at @OpenEphys and @MiniscopeTeam, or check out our websites: miniscope.org and open-ephys.org.

Open Neuro Interface (ONI)

The "open neuro interface," our next-generation acquisition standard, allows you to use the same cables, commutators, acquisition system, and software with Miniscopes, the new Open Ephys mouse headstage, and the Neuropixels probes. An intuitive, open API makes it straightforward to add new devices to the mix. This means that you are not locked into any one method when you decide what system to buy.

Acquisition systems

Next-gen PCIe system

Need ~unlimited channel count and submillisecond latency for your experiments? Got it. Easy support for future probes? Sure. Native @bonsai_rx integration? Of course! High quality configurable analog or digital I/O ? Yes. One system that works with pretty much any probe there is? Thanks to ONI that's now a thing. @OpenEphys will be showing the new PCIe system that Jon Newman (@__jonnew), Jack Zhang (@jiejackzhang) and Jakob Voigts (@jvoigts) developed.

Website, GitHub

New miniscope USB system

Want streamlined neuro-behavioral integration? Our common interface also comes as a USB DAQ platform developed as a joint collaboration between Daniel Aharoni (@DanielBAharoni) and Jon Newman(@__jonnew), Jack Zhang (@jiejackzhang), Jakob Voigts ( @jvoigts). Connect, control, stream, and record from 100's of devices simultaneously! This interface will also be oni compatible, obviously.

The classic Open Ephys system

It's used by hundreds of labs at more than 180 research institutions across the world. If you're curious about it, there's likely someone who can teach you more right down the hall.

The Open Ephys acquisition board is part of a complete platform for conducting multi-channel electrophysiology experiments that is being constantly improved and continuously supported. The latest revision was made earlier this year, adding new features like over-voltage protection on the power jack.

Website, GitHub

Ephys headstages/implants

New mouse ephys headstage

Jon Newman, Jack Zhang and Jakob Voigts made a new mouse headstage: 64 channels, 3D tracking, 2 LED drivers, electrical stimulation and accelerometer/gyro, all on a 0.3 mm tether via oni, commutated automagically. Total weight with 16 tetrode drive: 3.5g

Website, GitHub

New tetrode drive

The new Open Ephys tetrode drive implant can be built in a day and is extremely robust and adaptable. We designed this implant together with the new mouse headstage to make what we think is the best solution for tetrodes in mice. 16 tetrodes, 4.5 mm travel, configurable tetrode array layout, <3.5 g total, extremely thin tether, oni compatible.

Website @ Open Ephys, GitHub

Neuropixels support

The new oni enabled system now also supports Imec Neuropixels probes. As a nice side benefit, this system comes with the oni-interface and our new torque-free commutator. If you are interested, get in touch, we are planning to run a beta-test of the neuropixels integration later this year.

Miniscope implants

Miniscope v4

Daniel and the Miniscope team are demoing their next-gen, modular #Miniscope platform. 1 mm FOV, electronic focus, 120 FPS@full-res, 1 mm working distance, single flexible cable for power+data, open-source & configurable.

Dual-color Miniscope

Dual-color Miniscope capable of interleaved dual channel imaging as well as single channel imaging + simultaneous optogenetic stimulation. Being developed by @fsangiul and @MiniscopeTeam

New E-Scope

@MiniscopeTeam will be displaying their E-Scope: a Next-Gen Miniscope with integrated electrophysiology capabilities. Image 1,000+ neurons while simultaneously streaming 32 channels of ephys data all through a single, flexible cable. Supported by @NSF NeuroNex!

New Large FOV Miniscope

@MiniscopeTeam will have their new Large FOV Miniscope on display. This system, at under 15 grams, is capable of >3 mm x 2 mm FOVs with single-cell resolution. Being developed by @DanielBAharoni, @ChangliangGuo, @MIcheleABasso1, @pgolshani. Supported by the BRAIN Initiative

oni-enabled behavioral cameras

Also, the MiniscopeTeam has begun developing affordable, powerful behavioral cameras using the same connector and 2-wire cable as Miniscopes and @OpenEphys headstages. Making native integration of imaging, ephys, and behavior that much easier!

Tools

Twister3

Increase your throughput to 70 tetrodes an hour with this machine, developed by Jon Newman in collaboration with Jakob Voigts and SpikeGadgets. If you twist tetrodes on the regular, we highly recommend upgrading to this bad boy.

Website @ Open Ephys, GitHub

Cyclops LED driver

The best (and most affordable) LED driver on the market. Trusted by dozens of labs for fast and precise optogenetic stimulation. Developed by Jon Newman in order to complete his thesis work, which required the delivery of ultra-precise, continuously time-varying light waveforms for optogenetic stimulation.

Website @ Open Ephys, GitHub

Software

Bonsai

Bonsai is an open source visual language designed for making software systems that require rich and rapid interaction with the external world. It makes it simple to set up closed-loop feedback experiments that integrate physiology, audio and video streams, lick spouts, reward ports—any type of I/O, really. And it works out of the box with oni.

Website

Open Ephys GUI

The software that was originally developed for the classic Open Ephys acquisition board is now compatible with the Intan Recording Controller and Neuropixels probes. Designed from the ground up for extracellular electrophysiology experiments, it's the easiest way to get up and running with tetrodes or silicon probes.

Website @ Open Ephys, GitHub

New Miniscope DAQ Software

We will be demoing @MiniscopeTeam’s new Miniscope DAQ software in development. Real-time motion correction. Real-time dF/F. Real-time behavior tracking. Flexible HDF5 data structure. GPU accelerated real-time data visualization. Cross-platform support. Unlimited number of video streams.

Miniscope image processing and analysis

Curious about #Miniscope image processing and analysis? @phildong from @denisejcai's lab will be showing off his new Minian analysis package: https://github.com/DeniseCaiLab/minian.

Torque-free commutator

if you're using freely behaving animals you deal with twisting cables. Chances are you already spent thousands on commutators that promise to avoid tangling the tether by requiring low torque. How about a solution that requires zero torque? Our new oni-compatible commutator automagically knows which way the animal turns (via 3d-tracking and gyroscopes) and just turns the tether in sync. This means you can use crazy thin tethers and just forget this ever was a problem. And of course this commutator works with Bonsai and on all current and future oni-compatible headstages.

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