As they embark on a new adventure, they meet Jewel Bonnie, one of the "worst generations" in distress and seeking help.
It seemed that Bonnie had been rescued safely, but a giant shark-shaped robot suddenly appeared, and the Straw Hat Gang was torn apart in the sea.
Luffy, Chopper, Jinbee, and Bonnie managed to land on a certain island.
Meanwhile, Usopp and the others are drowning in the sea and are rescued by a giant robot. What came out of the robot was one of the Vegapunks, "Evil (Lilith)".
"Evil (Lilith)" threatens to give money and goods to replenish research funds. However, due to the unfathomable power of Zoro and Robin, he sensed that he would be defeated even if he continued to fight, and allowed Luffy and the others to land on a certain island.
The Straw Hat Gang landed on the future island of "Egghead". It was an island that was said to be "500 years in the future" and had the laboratory of the genius scientist "Dr. Vegapunk". A changing room that makes you wear clothes that look good on an unmanned cooker that puts out food one after another... Luffy and his friends are excited by a number of unknown technologies.
However, before Luffy and the others are having fun, Pacifista in the form of Bartholomew Bear attacks. Luffy tries to fight back, but Bonnie stops him. Wow, the bear is Bonnie's father! Moreover, it is said that it was Vegapunk who modified his father bear, who has now lost his ego and has become a "biological weapon", .......
Bonnie was chasing Vegapunk to get her father back.
While exploring Egghead, the Straw Hat Gang encounters a series of "Shaka", "Evil", "Edison", "Pythagoras", "Atlas", and "Greed" who call themselves Vegapunks. They were the alter egos of Vegapunk's personality divided into six parts.
To the audience's amazement at Egghead's scientific prowess, Vegapunk tells them that a country with an equally high civilization existed 900 years ago, and that he has a hypothesis about the lost 100 years. It was a forbidden history that led to the destruction of O'Hara. The world government, which sees Vegapunk as a danger as it tries to unravel history, orders the most powerful intelligence agency, CP0, to eliminate it. Sensing the danger, Vegapunk asks Luffy for help to take him out of Egghead.
However, there was no way he could escape easily.
The battle for command of the "strongest human race" Seraphims such as "S-Shark", "S-Snake", "S-Hawk", and "S-Bear", which was developed by Vegapunk in imitation of the Seven Warriors under the King, the tragic past of the bear that is revealed, the disappearance of Vegapunk itself, and the unexpected joint battle with Lucci and Kaku, who have a shallow connection to Luffy and the others. Then, the warships of the Navy, the Yellow Monkey, and even the Five Elder Stars attacked! Egghead and the Straw Hat Gang are engulfed in a vortex of chaos that ensues even more.
Will Luffy and the others be able to escape Egghead with Vegapunk safely?
And will Bonnie be able to get her father back?