Our team investigates how host cells mount innate defenses against viral infections. We focus on the interferon response and interferon-stimulated genes (ISGs), which play a central role in controlling viral replication. Our research targets RNA viruses of major public health importance, including HIV-1, influenza virus, SARS-CoV-2, and emerging mosquito-borne flaviviruses such as dengue (DENV), West Nile (WNV), and Zika (ZIKV) viruses. By integrating molecular virology, cell biology, and functional genomics, we aim to elucidate cellular antiviral mechanisms and identify viral vulnerabilities that can be exploited for the development of innovative antiviral strategies.