Nicolas Manel Lab

How do cells distinguish between self and non-self within their own intracellular environment? How do they detect viral invaders or altered states like cancer? And how does this fundamental distinction evolve with aging?

Our lab investigates the cellular mechanisms that define immunological identity from within. We explore how cells protect their identity while recognizing and responding to internal threats – such as viruses and cancer – and how these processes change with aging. By studying primary human immune cells, mouse models, cell lines, and leveraging computational approaches, our mission is to uncover novel biological insights that answer these questions.

We also strive to translate our discoveries into clinical applications.

The lab is hosted in the Immunity and Cancer department, at INSERM U932, Institut Curie, in the center of Paris.