Nicolas Manel Lab

PhD offer

One PhD position available within a European Marie Sklodowska-Curie ITN European Training Network “INITIATE-Innate-Immunometablism as Antiviral Target” (H2020-MSCA-ITN-2018). 15 total PhD positions available in the network.

See PDFs for eligibility, application instructions and list of projects.

Send all questions & your application to:



"Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS"

In The Journal of Experimental Medicine


The Manel Lab is recruiting a Bioinformatics Engineer.

In close collaboration with wet-lab researchers, you will design NGS experiments and analyse the data.

You will benefit from interactions with a core of 10+ bioinformaticians in the department and state-of-the art biological experiments (e.g. single-cell RNAseq, single-cell ChIP-seq)

2-year contract, salary based on experience.

Full details here.

Innate immunity is an ancient and universal form of defence against damages, threats and pathogens such as viruses. How the innate immunity distinguishes self from non-self (e.g. viruses) inside cells remains poorly understood. As a result, the ability to exploit innate immunity for anti-viral treatments, vaccines or cancer immunotherapy has remained limited.

The lab investigates the regulation, function and application of innate immunity. Our goal is to discover the molecular mechanisms that enable the immune system to distinguish self from non-self inside cells. We study HIV, other viruses and auto-immunity and development of the immune system. We use primary human immune cells, mouse models, cell lines and computational tools. We develop applications of our research for clinical use.

The lab is hosted in the Immunity and Cancer department, at INSERM U932, Institut Curie, in the center of Paris.