The new way to weight loss

The brain mechanism that enables us to maintain a constant body temperature may also be the key to rapid weight loss, a new study finds. In experiments involving mice that were given a calorie-restricted diet, scientists at Scripps Research discovered that blocking a brain receptor that normally regulates body heat resulted in significant weight reductions.

The findings will be further explored as a potential treatment approach for obesity, which the World Health Organization has called a global epidemic. Obesity affects virtually all age and socioeconomic groups--increasing risk for heart disease, stroke, diabetes, cancer and many other serious health conditions.

The new study, led by Scripps Research Professor Bruno Conti, PhD, appears in Current Biology.

"Up to 50 percent of what we eat every day is used as energy to maintain body temperature. But when food is scarce, mammals adapt by lowering their temperature, limiting energy expenditure and the loss of body weight."

Bruno Conti, PhD, Scripps Research Professor

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