No statistically significant differences were observed in clinical data (P/F ratio, SpO2, duration of hospitalization), cognitive performance (BRB-NT scores), or depression severity (BDI-II scores) between participants who reported the occurrence of hyposmia and/or dysgeusia and those who did not.
Additionally, we showed that mental processing speed reduction is not related to clinical characteristics such as SpO2 and P/F. We can therefore speculate that it results from brain alterations directly related to viral neurotropism and is not secondary to generalized hypoxemia or other systemic consequences of COVID-19. The presence of SARS-CoV-2 in the brain has been observed by postmortem studies and in vitro studies utilizing brain organoids [34,35,36].
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Finally, contrary to what we expected and to what was observed in a survey of the general population [49], the incidence of psychological sequelae was not particularly high, with only 16% (15.79%) of participants reporting clinically relevant depressed mood at the time of neuropsychological testing.
Da Gennaio 2018 presso la Clinica Veterinaria San Carlo si occupa di medicina interna, seguendo in particolare i pazienti ricoverati per patologie gravi di origine endocrina ed immuno-mediata, e di neurologia clinica, effettuando visite specialistiche su appuntamento.
Our study is a randomized, double-blind, placebo-controlled, multicenter clinical trial. We will recruit 86 patients with intracerebral hemorrhage of both sexes, aged >18 years, from four Mexican hospitals. The patients will receive either 20 mg of fluoxetine or a placebo once daily for 90 days. The primary outcome is the mean change in the Fugl-Meyer Motor Scale score between inclusion (day 0) and day 90. The secondary outcomes will be changes in the Barthel Index, the Modified Rankin scale and the National Institutes of Health stroke scale. The outcomes will be measured at day 42 7days and at day 90, for a total of four visits with each subject (at screening and at 0, 42 and 90 days).
This study will be the first reported randomized, double-blind, placebo-controlled clinical trial of the use of fluoxetine for motor recovery in patients with ICH. The main purpose of this study is to test whether a three-month treatment with fluoxetine enhances motor recovery in nondepressed patients with acute intracerebral hemorrhage.
A sample size of 35 in each group will be sufficient to detect a clinically important difference of 14.5 points on the FMMS, assuming a standard deviation of 21.3 FMMS points on the basis of the findings of the fluoxetine in motor recovery of patients with acute ischaemic stroke (FLAME) trial [12], using a two tailed t-test of the difference between means, a power of 80%, and a significance level of 5%. This number has been increased to 44 per group (total of 88), to allow for a predicted 20% loss to follow-up.
Data quality control will be achieved through monitoring during the trial. After checking the written CRF, well-trained clinical research associates of the principal investigator will collect the data.
Fisiopatologia della pressione intracranica. Cause dell'ipertensione intracranica. Trattamento medico e chirurgico dell'ipertensione intracranica. Il flusso ematico cerebrale. La pressione di perfusione cerebrale (CPP) e sue relazioni con la pressione intracranica. Ernie cerebrali.La nevralgia trigeminale. La decompressione neurovascolare.Le malformazioni vascolari cerebrali.Le malformazioni arterovenose. Presentazione clinica. Imaging. Il trattamento chirurgico, endovascolare e radiochirurgico. Gli angiomi cavernosi. Le teleangectasie capillari. Le fistole arterovenose durali intracraniche. Presentazione clinica. Diagnostica. Il trattamento chirugico e endovascolare.L'emorragia subaracnoidea (ESA). Gli aneurismi intracranici. Aneurismi a bacca, fusiformi, dissecanti, micotici. Fisiopatologia dell'ESA. Il vasospasmo clinico e radiologico. Trattamento del vasospasmo. L'idrocefalo post-ESA. Il trattamento chirurgico degli aneurismi. Il trattamento endovascolare.
Overall, 116 patients entered the study randomly assigned to DHEC (56) and to PRAM (60). At baseline, the two groups were homogeneous with regards to demographic and clinical characteristics (see Table 1). be457b7860
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