Following the events of the previous film Casino Royale, James Bond is driving from Lake Garda to Siena, Italy, with the captured Mr. White in the trunk of his Aston Martin DBS V12. After evading pursuers, Bond delivers White to M, who interrogates him regarding the mysterious organisation, Quantum. When White responds that their operatives are everywhere, M's bodyguard Craig Mitchell suddenly shoots one of the guards and attacks M, enabling White to escape. Bond chases Mitchell and eventually kills him, but White escapes. After returning to London, and searching Mitchell's flat, Bond and M discover Mitchell had a contact in Haiti, Edmund Slate. Bond learns Slate is a hitman sent to kill Camille Montes at the behest of her lover, environmentalist entrepreneur Dominic Greene. Observing her subsequent meeting with Greene, Bond learns Greene is helping exiled Bolivian General Medrano, who murdered Camille's family, to overthrow the government and become the new president, in exchange for a seemingly barren piece of desert.
After rescuing Camille from Medrano, Bond follows Greene to a performance of Tosca in Bregenz, Austria. Meanwhile, the head of the CIA's South American section, Gregg Beam, along with agent Felix Leiter, strike a noninterference deal with Greene for access to putative stocks of Bolivian oil, which the CIA believes to be the reason for Greene's interest in the land. Bond infiltrates Quantum's meeting at the opera, identifying members of Quantum's executive board, and a gunfight ensues. A Special Branch bodyguard working for Quantum member Guy Haines, an advisor to the British Prime Minister, is killed by one of Greene's men after Bond throws him off a roof. As M assumes Bond killed him, she has his passports and credit cards revoked. Bond heads to Italy and convinces his old ally René Mathis (whose innocence was confirmed after the events of Casino Royale) to accompany him to Bolivia. They are greeted by Fields, a consular employee who demands Bond return to the UK immediately. Bond seduces her, and they attend a fundraising party Greene holds that night. At the party, Bond again rescues Camille from Greene and they leave. The Bolivian police pull Bond and Camille over but discover Mathis unconscious in the car's boot. One of the policemen shoots Mathis before Bond kills both of them. Mathis dies in Bond's arms, urging him to forgive Vesper and himself.
The following day, Bond and Camille survey Quantum's intended land acquisition by air; their plane is shot down by a Bolivian fighter aircraft, before being crushed in the mountains and ignited. They skydive into a sinkhole and discover Quantum has been secretly damming Bolivia's supply of fresh water to create a monopoly. Back in La Paz, Bond meets M and learns Quantum killed Fields by drowning her in crude oil. Bond meets Leiter, who discloses Greene and Medrano will meet in the Atacama Desert to finalize their agreement. Warned by Leiter, he evades the CIA's Special Activities Division.
At a facility in the desert, Greene has Medrano sign a contract that will make Medrano the leader of Bolivia in exchange for the land rights. When Medrano realises that the land rights make Greene Bolivia's sole provider of water at significantly higher rates, he refuses, but is forced to sign when Greene threatens him. Bond and Camille infiltrate the complex. Bond kills the chief of police for betraying Mathis, and after killing the security detail, he confronts Greene. Meanwhile, Camille kills Medrano, avenging the murders of her family. The struggle leaves the facility destroyed by fire. Bond captures Greene and interrogates him about Quantum. Bond leaves him stranded in the desert with only a can of engine oil. Bond and Camille share a kiss, and she wishes him luck in conquering his demons.
Bond travels to Kazan, Russia, where he finds Vesper Lynd's former lover, Yusef Kabira, a member of Quantum who seduces women agents with valuable connections and is indirectly responsible for her death. After saving Kabira's latest target, Bond allows MI6 to arrest Kabira, unharmed. Outside, M tells Bond that Greene was found dead in the middle of the desert, shot twice in the neck and some engine oil found in his stomach. M tells Bond she needs him back; he responds that he never left. As he walks away, Bond drops Vesper's necklace behind him in the snow.
Daniel Craig as James Bond
Olga Kurylenko as Camille Montes
Mathieu Amalric as Dominic Greene
Giancarlo Giannini as René Mathis
Gemma Arterton as MI6 agent Strawberry Fields
Anatole Taubman as Elvis,
Jesper Christensen as Mr White
David Harbour as Gregg Beam
Rory Kinnear as Bill Tanner, M's aide.
Tim Pigott-Smith as the British Secretary of State for Foreign and Commonwealth Affairs.
Joaquín Cosío as General Medrano
Jeffrey Wright as Felix Leiter
the twenty-second in the James Bond series