Sam Bell (Hugh Laurie) and his wife Lucy (Joely Richardson) are a married couple struggling for a baby, having tried everything they can think of to improve their chances of conceiving. At the same time, Sam begins to find his job (as a commissioning editor of drama at the BBC) increasingly unfulfilling. While he resolves to write his own screenplay, he begins to suffer writer's block.
The idea dawns upon him to write about his own predicament, something to which Lucy objects strongly. He uses her diary entries to help him achieve authenticity, and the film is a success. Lucy finds out about the film and, shocked, leaves Sam. Eventually they reconcile, and at the end of the story are still trying for a baby.
It marks the second time Laurie and Richardson have starred in the same film; the first was 101 Dalmatians (although in that film they shared no scenes).
Hugh Laurie as Sam Bell
Joely Richardson as Lucy Bell
Matthew Macfadyen as Nigel
Adrian Lester as George
Yasmin Bannerman as Melinda
Joanna Lumley as Sheila
Rachael Stirling as Joanna
Dave Thompson as Dave the Comedian
Emma Thompson as Druscilla
James Purefoy as Carl Phipps
Tom Hollander as Ewan Proclaimer
Rowan Atkinson as Mr. James
Kelly Reilly as Nimnh
Dawn French as Charlene
based upon Ben Elton's 1999 novel, Inconceivable