Washington, D.C. detective and forensic psychologist Alex Cross heads to Durham, North Carolina when his niece Naomi, a college student, is reported missing. He learns from police detective Nick Ruskin that Naomi is the latest in a series of young women who have vanished. Soon after his arrival, one of the missing women is found dead, bound to a tree, and a short time later, Kate McTiernan is kidnapped from her home.
When she awakens from a drugged state, Kate discovers that she is being held by a masked man calling himself Casanova, and she is one of several prisoners trapped in his lair. She manages to escape and is severely injured when she jumps from a cliff into a river. After she recuperates, she joins forces with Cross to track down her captor, whom Cross concludes is a collector, not a killer, unless his victims fail to follow his rules. This means there is time to rescue the other imprisoned women, as long as they remain obedient.
Clues lead them to Los Angeles, where a series of gruesome kidnappings and murders have been credited to Dr. William Rudolph, known as the Gentleman Caller. Cross's efforts to capture and question Rudolph are foiled when Rudolph escapes. In North Carolina, Cross traces Casanova up the river. Alerted by a gunshot, he discovers Casanova's underground hideout. Rudolph is revealed to be Casanova's partner. Casanova escapes, while Rudolph is shot by Cross. Cross rescues the kidnapped women, including Naomi.
Later, Kate invites Cross to dinner at her house. Ruskin drops by Kate's house and sends home the two officers guarding her. While Cross is at home preparing to meet Kate for dinner, he discovers that Ruskin's signature on the arrest warrants matches Casanova's handwriting. Cross tries calling Kate to inform her, but Ruskin has already disconnected her phone line. Kate becomes suspicious of Ruskin while conversing with him. He then drops his accent, revealing he is Casanova. After a fight and attempted rape, Kate manages to handcuff him to the oven. Ruskin slashes Kate's arm with a kitchen knife. In attempting to free himself, Ruskin pulls the oven away from the wall, rupturing the gas pipe. Ruskin takes out a lighter, threatening to cause an explosion due to the leaking gas. Cross shows up and tries to discourage Ruskin. When this fails, Cross shoots Ruskin, firing through a milk carton to avoid igniting the gas. Cross comforts Kate as the police arrive.
Morgan Freeman as Dr. / Detective Alex Cross
Ashley Judd as Dr. Kate McTiernan
Cary Elwes as Detective Nick Ruskin
Alex McArthur as Detective Davey Sikes
Bill Nunn as Detective John Sampson
Jeremy Piven as Detective Henry Castillo
Brian Cox as Chief Hatfield
Jay O. Sanders as FBI Agent Kyle Craig
Tony Goldwyn as Dr. William Rudolph
William Converse-Roberts as Dr. Wick Sachs
Roma Maffia as Dr. Ruocco
Richard T. Jones as Seth Samuel
Gina Ravera as Naomi Cross
Heidi Schanz as Megan Murphy
Tatyana Ali as Janelle Cross
Mena Suvari as Coty Pierce
Anna Maria Horsford as Vickie Cross
Helen Martin as Nana Maybellene Cross
based on James Patterson's best-selling 1995 novel of the same name
prequel to Along Came a Spider