On May 13, 2000, high school student Alex Browning boards Volée Airlines Flight 180, a Boeing 747 with his classmates for their senior trip to Paris Charles de Gaulle Airport from New York John F. Kennedy Airport. Before takeoff, Alex has a premonition that the plane will explode in mid-air, killing everybody on board. When the events from his vision began to occur in reality, he panics until a fight breaks out between him and student Carter Horton. As a result, both of them are removed from the plane including Alex's best friend Tod Waggner, Carter's girlfriend Terry Chaney, teacher Valerie Lewton, and students Billy Hitchcock and Clear Rivers. None of the other passengers, except Clear, believe Alex about his vision until the plane explodes on takeoff. Afterwards, the survivors are interrogated by two FBI agents Weine and Schreck who both displayed their suspicions towards Alex.
Thirty-nine days later after attending a memorial service for the victims, an unusual chain reaction causes Tod to accidentally hang himself in his shower that night. When his death was ruled as a suicide, Alex sneaks into the funeral home along with Clear to examine Tod's corpse when the mortician William Bludworth reveals that the survivors who escaped from the impending circumstance have disrupted Death's plan and is now claiming the lives of those who were meant to die from the accident. Alex and Clear discuss their next move when the rest of the survivors arrive outside the café where Terry is run over and killed by a speeding bus on the road.
After watching a news report on the cause of the explosion, Alex concludes that Death is reclaiming the survivors according to the sequence of their intended demises on the plane. Nonetheless, he is too late to save Ms. Lewton, whose house explodes after she is impaled by a falling kitchen knife. The remaining survivors reunite, and Alex explains the situation as they drive through town. Carter (who would be next, according to Alex's plan) is still enraged over Terry's death and stops his car on a train crossing. The others flee the car, but Carter plans to die on his own terms, finally changing his mind at the last minute when his seatbelt jams. Alex saves him just before the car is smashed by an oncoming train, but it flings shrapnel from the wreckage into the air, decapitating Billy. Alex surmises that because he intervened in Carter's death, Death skipped to the next person in the original sequence.
The next day while hiding out in a fortified cabin, Alex recalls changing seats in his premonition, but he did not do so in reality, and realizes that Clear is actually next. He rushes to her house to save her while being pursued by Weine and Schreck. Alex finds Clear who is trapped inside her car surrounded by loose electrical cables that ignite a gasoline leak around her. He grabs the cable, allowing her to escape from the car just before it explodes.
Six months later, Alex, Clear, and Carter travel to Paris to celebrate their survival. While discussing their ordeal, Alex reveals that Death never skipped him after he saved Clear. Fearing that their struggle is unfinished, Alex retreats when a bus hurls parking signage towards a neon sign which descends towards him. Carter pushes Alex out of the way at the last second but the sign swings back down towards the former and kills him, leaving Death's plan to resume action.
Devon Sawa as Alex Browning
Ali Larter as Clear Rivers
Kerr Smith as Carter Horton
Kristen Cloke as Valerie Lewton
Daniel Roebuck as Agent Weine
Roger Guenveur Smith as Agent Schrek
Chad E. Donella as Tod Waggner
Seann William Scott as Billy Hitchcock
Tony Todd as William Bludworth
Amanda Detmer as Terry Chaney
Brendan Fehr as George Waggner
Forbes Angus as Larry Murnau
Lisa Marie Caruk as Christa Marsh
Christine Chatelain as Blake Dreyer
Barbara Tyson as Barbara Browning
Robert Wisden as Ken Browning
P. Lynn Johnson as Mrs. Waggner
Larry Gilman as Mr. Waggner
Fred Keating as Howard Siegel
based on a story by Reddick. It is the first installment in the Final Destination film series