Ex-fighter pilot Ted Striker is a traumatized war veteran turned taxi driver. Because of his pathological fear of flying and "drinking problem" (being unable to take a drink without splashing it on his face), he has been unable to hold a responsible job. His wartime girlfriend, Elaine Dickinson, now a flight attendant, leaves him before boarding her assigned flight from Los Angeles to Chicago. Ted abandons his taxi and buys a ticket on the same flight to try to win her back. However, she still continues to reject him during the flight.
After the in-flight meal is served, several of the passengers and the flight crew fall ill, including Captain Oveur. Passenger Dr. Rumack discovers that the fish served onboard caused food poisoning. With the flight crew incapacitated, Elaine contacts the Chicago control tower for help, and is instructed by tower supervisor Steve McCroskey to activate the plane's autopilot, a large inflatable pilot dummy dubbed "Otto", which will get them to Chicago, but will not be able to land the plane. Elaine and Dr. Rumack convince Ted to take the controls. When Steve learns that Ted is piloting, he contacts Ted's former commanding officer, Rex Kramer, now serving as a commercial pilot, so that he can help talk Ted through landing the plane. Ted becomes troubled when Rex starts giving instructions, and briefly stresses out from flashbacks to the war. Both Elaine and Dr. Rumack bolster Ted's confidence and he takes the controls under Rex's guidance.
As the plane nears Chicago, the weather worsens, making landing difficult. With Elaine's help as co-pilot and Rex's guidance, Ted is able to land the plane safely with the passengers suffering only minor injuries, despite the landing gear being sheared off. Rescue vehicles arrive to help unload the plane. Impressed by Ted's display of courage, Elaine embraces and kisses him, rekindling their relationship. The two watch as "Otto" takes control of the plane, inflates a female companion, and takes off.
Robert Hays as Ted Striker
Julie Hagerty as Elaine Dickinson
Leslie Nielsen as Dr. Rumack
Peter Graves as Capt. Clarence Oveur
Lloyd Bridges as Steve McCroskey
Robert Stack as Capt. Rex Kramer
Lorna Patterson as Randy
Stephen Stucker as Air Traffic Controller Johnny Henshaw-Jacobs
Frank Ashmore as Victor Basta
Jonathan Banks as Gunderson
Kareem Abdul-Jabbar as Roger Murdock
Craig Berenson as Paul Carey
Barbara Billingsley as Jive Lady
Lee Bryant as Mrs. Hammen
Nicholas Pryor as Jim Hammen
Joyce Bulifant as Mrs. Davis
Maureen McGovern as Nun
Kenneth Tobey as Air Controller Neubauer
Marcy Goldman as Mrs. Geline
Barbara Stuart as Mrs. Kramer
Rossie Harris as Joey Hammen
Norman Alexander Gibbs as 1st Jive Dude
Al White as 2nd Jive Dude
David Hollander as the young boy with coffee
Michelle Stacy as the young girl with coffee
David Leisure as First Krishna
Jason Wingreen as Dr. Brody
Jill Whelan as Lisa Davis
Ethel Merman as Lt. Hurwitz
Lee Terri as Mrs. Linda Oveur
Jimmie Walker as Windshield Wiper Man
James Hong as Japanese General
Howard Jarvis as the Man in the Taxi
Michael Laurence as a Newscaster
a parody of the disaster film genre, particularly the 1957 Paramount film Zero Hour!, from which it borrows the plot and the central characters, as well as many elements from Airport 1975 and other films in the Airport series