Some flashes also have the ability to create speed avatars (i.e. duplicates) and these avatars have sometimes been sent to different timelines to complete a particular mission. (Barry Allen exhibits this ability in the live action series "The Flash").
Our industry continues to thrive and grow with new technology and more applications than ever. FMS has expanded to an all- inclusive memory and storage summit welcoming all emerging memory and storage solutions The scope of FMS23 will include DRAM, DNA data storage, UCIe chiplet interconnects, Compute Express Link (CXL), wearables, automotive, AI/ML, data centers, and entertainment applications, along with 3D flash, NVMe, ZNS, and important industry announcements. As one past attendee put it, "Flash is a big society and FMS is the right show."
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About FLASH FLASH (Fast Length Adjustment of SHort reads) is a very fast and accurate software tool to merge paired-end reads from next-generation sequencing experiments. FLASH is designed to merge pairs of reads when the original DNA fragments are shorter than twice the length of reads. The resulting longer reads can significantly improve genome assemblies. They can also improve transcriptome assembly when FLASH is used to merge RNA-seq data.
Accuracy FLASH merges reads from paired-end sequencing runs with very high accuracy.
FLASH accuracy on one million 100bp long synthetic pairs generated from fragments with a mean length of 180bp, normaly distributed with a standard deviation of 20bp:
No error 1% error rate 2% error rate 3% error rate 5% error rate default parameters 99.73% 99.68% 98.43% 94.76% 77.91% more aggressive parameters 99.73% 99.68% 99.06% 98.30% 93.65%
Simulated reads used in the experiments are available here:
No error
1% error
2% error
3% error
5% error
FLASH accuracy on real data:
647,052 pairs of 101bp long reads from Staphylococcus aureus 90.77% 18,252,400 pairs of 101bp long reads from human 91.02%
The reads are available at the GAGE site: Reads from GAGE Time requirements The latest version of FLASH includes a multi-threaded mode.
When run in single threaded mode:
FLASH takes 120 seconds to process one million 100-bp long pairs on a server with 256GB of RAM and a six-core 2.4GHz AMD Opteron CPU. FLASH takes 129 seconds to process one million 100-bp long pairs on a desktop with 2GB of RAM and a dual-core Intel Xeon 3.00GHz CPU. Time is linearly proportional to the read length and the number of reads. Impact of FLASH on genome assemblies Merging mate pairs by FLASH as a pre-processor for genome assembly yields singificantly higher N50 value of contigs and scaffolds. It also reduces the number of missassembled contigs.
Publication FLASH: Fast length adjustment of short reads to improve genome assemblies. T. Magoc and S. Salzberg. Bioinformatics 27:21 (2011), 2957-63.
Obtaining the Software This software is OSI Certified Open Source Software.
FLASH code or executable can be downloaded from Sourceforge. Release packages can also be directly downloaded from here: source package: FLASH-1.2.11.tar.gz precompiled Linux x86_64 binary: FLASH-1.2.11-Linux-x86_64.tar.gz precompiled Windows binary: FLASH-1.2.11-windows-bin.zip Questions/Comments/Requests Send an e-mail to flash.comment@gmail.com.
Funding This work has been supported in part by NIH grants R01-LM006845, R01-GM083873, and R01-HG006677 to S.L. Salzberg. The Center for Computational Biology at Johns Hopkins University
This page contains binary image files that allow you to restore your Nexusor Pixel device's original factory firmware. You will find these files usefulif you have flashed custom builds on your device, and wish to return yourdevice to its factory state.
After taking an Android 13 update and successfully booting the device postupdate, an Android 12 build resides in the inactive slot (seamless updatesfor more information on slots) of the device. The inactive slot contains anolder bootloader whose anti-rollback version has not been incremented.If the active slot is then flashed with a build that fails to boot, thefallback mechanism of seamless updates kicks in and the device tries toboot from the inactive slot. Since the inactive slot contains the olderbootloader, the device enters an unbootable state.
To avoid hitting this state, if you are flashing a Pixel 6, Pixel 6a, orPixel 6 Pro device with an Android 13 build for the first time, pleaseflash the bootloader partition to the inactive slot after successfullyupdating and booting into Android 13 at least once. This can be done byfollowing these steps:
Extract the contents of the factory ROM .zip file, identify thebootloader image in the extracted files, and follow the sequence of eventsas listed below to flash the bootloader to both the slots. Substitute thename of the bootloader image with that of your device for the Pixel 6 andPixel 6a.
After flashing the inactive slot bootloader to an Android 13 bootloader,reboot to that slot to ensure that the bootloader will be marked asbootable. Important: Please run the exact sequence of commands as listedbelow. Don't forget to enter the full line fastboot reboot bootloader whenrebooting. Failure to do so may leave your device in an unbootable state.
The flash provides a way to pass temporary primitive-types (String, Array, Hash) between actions. Anything you place in the flash will be exposed to the very next action and then cleared out. This is a great way of doing notices and alerts, such as a create action that sets flash[:notice] = "Post successfully created" before redirecting to a display action that can then expose the flash to its template. Actually, that exposure is automatically done.
This example places a string in the flash. And of course, you can put as many as you like at a time too. If you want to pass non-primitive types, you will have to handle that in your application. Example: To show messages with links, you will have to use sanitize helper.
Flash floods are rapid increases of water in streams and creeks, typically in response to intense rainfall events, that pose significant hazards to motorists, recreationalists, and infrastructure worldwide. The small space-time scales associated with flash floods have made it challenging to predict the precise locations of impending rainfall and resultant impacts.
The Flooded Locations And Simulated Hydrographs Project (FLASH) was launched in early 2012 largely in response to the demonstration and real-time availability of high-resolution, accurate rainfall observations from the MRMS/Q3 project. FLASH introduces a new paradigm in flash flood prediction that uses the MRMS forcing and produces flash flood forecasts at 1-km/5-min resolution through direct, forward simulation. The primary goal of the FLASH project is to improve the accuracy, timing, and specificity of flash flood warnings in the US, thus saving lives and protecting infrastructure. The FLASH team is comprised of researchers and students who use an interdisciplinary and collaborative approach to achieve the goal.
Unlike slow-evolving drought, which is caused by a decline in precipitation, flash drought occurs when low precipitation is accompanied by abnormally high temperatures (e.g., heat waves), high winds, and/or changes in radiation. These sometime-rapid changes can quickly raise evapotranspiration rates and remove available water from the landscape.
The prediction of flash drought is critical to successfully mitigating and preventing damages whenever possible. Scientists have identified evapotranspiration and soil moisture as early warning indicators for the development of flash drought. Changes in evapotranspiration correspond with flash drought in the contiguous United States, indicating that it may be a primary mechanism involved in the sudden onset and intensification of drought conditions.
In one study, researchers found that all flash droughts studied were preceded by sudden increases in evapotranspiration rates caused by changes in heat, wind, and radiation. Soil moisture was plentiful prior to the onset of drought, but decreased as evapotranspiration rates rose. They concluded that changes in evapotranspiration rates are a strong indicator of flash drought (Chen et al. 2020).
Despite the importance of prediction, scientists have found that flash droughts occur even when conditions just two months prior to the event appeared to be unfavorable for drought development, demonstrating that flash drought can occur even when there are no preceding signs that can be detected with known metrics (Christian et al. 2019). Better prediction of flash droughts is an active area of research. NOAA's Climate Prediction Center is currently working on an experimental rapid onset (flash) drought product as a component of their Week-2 U.S. Hazards Outlook.
Flash drought occurs more often than many people realize and can cause major impacts. Significant negative impacts to the agricultural sector have been better documented than impacts to other sectors and the environment. Flash drought has occurred in the southeastern United States as recently as the fall of 2019. In a widespread flash drought across the central U.S. during the summer of 2012, damages in the central Great Plains were estimated to be in excess of $30 billion.
Although most flash droughts do not persist to become prolonged drought, in one study, 5 to 10 percent of flash droughts transitioned to the highest drought category given by the U.S. Drought Monitor: Exceptional Drought, or D4 (Christian et al. 2019).
The Flash Grant program identifies and energizes creative ideas that exhibit early indications of exceptional commercial potential. Like a flash of inspiration, flash grants infuse a quick jolt of funding at a critical early point when a small, targeted influx of funds is crucial to shaping innovative research ideas into high-potential life sciences technologies.
Flash grants support short, tightly-focused research projects in these two categories: be457b7860
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