MultiSec: Multi-task Deep Learning Improves Secreted Protein Discovery in Human Body Fluids

A fast and accurate method that can discover secreted proteins in 17 human body fluids simultaneously

3. Potentially universal secreted proteins

1. MultiSec description

MultiSec is a framework that can discover secreted proteins in human body fluids. By exploiting the relationships between 17 different body fluids, this method has detected more accurately potentially secreted proteins in 17 human body fluids than other available methods (paper).

Furthermore, we also use MultiSec to identify potential secreted proteins and the results are in the following two parts. The code of MultiSec can be downloaded from here (code).

2. Potentially secreted proteins

MultiSec was applied to identify potentially secreted proteins (PSPs) in 17 human body fluids. The PSPs are proteins that were not verified by experiment but predicted as positive by our method. The PSPs for each body fluids are showed in the right.

3. Potentially universal secreted proteins

Among these PSPs, 103 PSPs were found in all 17 groups, which means our approach predicted these PSPs to be secreted into all 17 human body fluids. We refer to these 103 PSPs as potentially universal secreted proteins (PUSPs). We believe that these 20 PUSPs are more worthwhile to discover than others because they are more likely to be simultaneously secreted in 17 human body fluids.

PUSPs