MKU LAB ACTIVITIY CORNER
PRINCIPAL INVESTIGATOR
Dr. Manish Kumar
Associate Professor
Department of Biophysics, University of Delhi South Campus
PhD Institute of Microbial Technology, Chandigarh, India 2008
Joined Department of Biophysics, UDSC Faculty in 2010
Post Doctoral Scholar (McGill University, Montreal, Canada) 2009-10
Dr. Manish Kumar is an Associate Professor at the Department of Biophysics University of Delhi South Campus, New Delhi India. Main research focus of Dr. Kumar's laboratory is analysis of microbial genomes and proteomes using bioinformatics, chemi-informatics and phylogenomics tools to understand the mechanisms behind evolution and spread of virulence and antibiotic resistance among microbial pathogens. We use molecular modeling and computer-based simulation techniques for structure-based drug designing, translational medicine and protein family based approaches to design and identify drug-like compounds. We predict functional interactions between proteins in metabolic and signaling pathways or protein complexes and use this information to develop new drug targets. We also use Next Generation Sequencing based metagenomic data to analyze the load of antibiotic resistance genes in different biotic reservoirs.
Another major interest of lab is development of annotation pipelines. The information content of genome databases has and being increasing rapidly due to significant reduction in cost of high-throughput gene/genome sequencing. But the annotation pipelines for the same are comparatively less resulting in a large number of incomplete/improperly-annotated genomes. My research group is using and developing ‘in house’ bioinformatics tools for functional annotation of genes, functional and structural prediction of encoded proteins, and reconstruction of metabolic, regulatory and transport networks for complete annotation of the sequenced genomes.
POST-DOCTORAL FELLOWS
Dr. Nambram Somendro Singh
somendro_nambram@yahoo.co.in
Somendro's research work mainly involves in antibiotic resistance conferred by β-lactams, quinolones and aminoglycosides in Escherichia coli. I did my Ph.D. under the supervision and guidance of Prof. Jugsharan Singh Virdi, from the Department of Microbiology, University of Delhi South Campus. Currently working as Research Associate in an ICMR project- entitled "In-silico analysis and functional characterization of intergenic regions of ESKAPE pathogens to develop novel drug targets." under Dr. Manish Kumar (Assistant Professor), Department of Biophysics, University of Delhi South Campus
GRADUATE STUDENTS
Anjali Garg
agarg006@gmail.com
Anjali is work on host-pathogen interaction trying to understand the phenomenon of molecular mimicry which is cross-talk between pathogens and host protein. She tried to predict functional interactions between proteins in metabolic and signaling pathways or protein complexes and use this information to develop new drug targets.
Deeksha Pandey
deeksha.pandey.biophysics@south.du.ac.in
Deeksha’s research focuses on analysing the different factors that contribute in development of bacterial antibiotics resistance in microbial pathogens. Prior to starting her Ph.D., she did one year project as a designation of Junior research fellow (JRF) at DBT-Bioinformatics Infrastructure Facility, Sri Venkateswara College, University of Delhi, she also completed her M.tech and Post graduate diploma in Bioinformatics at Banasthali University, Rajasthan, INDIA.
Manisha Aswal
manisha.aswal82@gmail.com
Manisha's research interest lies in computational identification and analysis of virulence factors in pathogenic microbes. Currently availing CSIR JRF/SRF fellowship. She did MSc. From Department of Biochemistry (UDSC)
Govinda Rao Dabburu
govinddabburu00012@gmail.com
Govind's research interest lies Deep annotation of microbial genomes and structure based drug designing. He did M.S Pharma Pharmacoinformatics from NIPER (Hajipur)
Aakriti Jain
aakritij95@gmail.com
Aakriti's research area revolves around multi-omic investigation of resistance mechanism of pathogenic fungi. She did postgraduate from Department of Plant Molecular Biology, University of Delhi.
ALUMNI
Dr. Bandana Kumari: Post Doctoral Fellow, Institute of Human Genomics, CNRS, France
Dr. Abhishikha Srivastava: Post Doctoral Fellow, McGill University, Canada
Dr. Ravindra Kumar: Post Doctoral Fellow, National Institute of Health, USA
Dr. Sohni Singh Jain: Grant Officer, Royal Melbourne Institute of Technology, Melbourne, Australia