Minah Suh lab
Our laboratory aims to understand the underlying mechanisms of physiological interactions among neurons, glias and vascular system by using multimodal imaging methods.
Study the effect of stress on neurovascular coupling at functional and structural levels
Study the effect of pathologically heightened neuronal excitation and synchronization on neurovascular coupling at functional and structural levels
Study neurovascular coupling mechanism of vasomodulators
Develop novel techniques to restore neurovascular coupling dysfunction
Study the effect of microglia in the prevention and therapy of neurodegenerative diseases
In vivo neuronal responses following 4-AP seizure induction : excitatory and inhibitory neurons
Behavior test (Open field test & Elevated plus maze test)
In vivo BBB permeability imaging
In vivo Intrinsic optical signal (IOS) imaging
In vivo microglial response to local brain injury
Immunostaining (Pyramidal neurons & inhibitory interneurons in neocortex and hippocampus)
Cover image (Cerebral Cortex Volume 32, Issue 24, 15 December 2022)
A confocal microscopy image is showing that the number of parvalbumin-expressing inhibitory neurons are increased in the DG of the hippocampus after deep brain stimulation of the anterior nuclei of the thalamus in epileptic mice. BrdU positive cells (green) which are newly generated cells also increased in the DG region and some of them are colocalized with PV expressing neurons (yellow), which indicates that DBS can result in cellular changes by increasing neurogenic substances. See Bae et al. 2022. Deep brain stimulation of the anterior nuclei of the thalamus can alleviate seizure severity and induce hippocampal GABAergic neuronal changes in a pilocarpine- induced epileptic mouse brain. Cereb Cortex 32(24): 5530-5543.