Mike Kuhar's Resume

Welcome

Professional Curriculum Vitae (Resume) of Dr. Michael J Kuhar .    A full and detailed version is available on request.

7/14/2025

               TABLE OF CONTENTS

General Information                           

Professional Societies                           

Honors and Other Experience              

Editorial Boards                                

Seminar and Other invitations              

Selected Books and Volumes               

Patents                                                       

Selected Research Journal Articles      

Abstracts                                             

Selected Chapters, Reviews and Other

Students, Fellows and Trainees             

Teaching and Related Contributions    

Grant Support                                            

                                                     Legal Expert Witness Consulting           Separate Attachment

                                                                                 CURRICULUM VITAE/RESUME

                                                                                              Michael Joseph Kuhar

Address:    Emory National Primate Research Center of Emory University

                      e-mail: mkuhar@emory.edu;  mkuhar@bellsouth.net

                      Web site:  http://www.mikekuhar2024.com 

Education: 1965, B.S., University of Scranton,

                      Scranton, Pennsylvania, Departments of

                      Physics and Philosophy, Magna cum Laude

                      1965-66, Harvard University,

                      Cambridge MA, Physics (no degree, transfer to Johns Hopkins)

                      1970, Ph.D., The Johns Hopkins University,

                      Baltimore, Maryland, Departments of Biophysics

                      and Pharmacology

                      1988, Graduate Certificate in Substance Abuse Counseling, Loyola University

                      Baltimore MD.

Last Position At Emory University:         

                      November 1995 – September 1, 2023, Candler Professor (tenured), Emory University

                      Candler Professor Emeritus, September, 2023

                      Sept 1, 2023 - Dec 31, 2023, Adjunct Professor of Pharmacology and Chemical Biology

                      Professor, Department of Pharmacology and Chemical Biology

                      Professor, Dept of Psychiatry and Behavioral Sciences (Adjunct)

                      Charles Howard Candler Professor of Neuropharmacology

                      Georgia Research Alliance Eminent Scholar (Emeritus in 2022)

                      Center for Ethics, Senior Faculty Fellow (2009-2023)

                      Adjunct Professor, Division of Behavioral Neuroscience and Psychiatric Disorders

                      Chief of the Neuroscience Division, 1995-2010, at the

                      Yerkes (now Emory) National Primate Research Center

Previous Positions:

                      July 1985‑November 1995

                      Chief, Neuroscience Branch,

                      Addiction Research Center

                      National Institute on Drug Abuse

                      Professor, Part‑time (1985-95), The Johns Hopkins

                      University School of Medicine, Departments of

                      Neuroscience, Pharmacology and Psychiatry

                      July 1981-1985, Professor, The Johns Hopkins University

                      School of Medicine, Departments of Neuroscience,

                      Pharmacology and Psychiatry

                      July 1980, Associate Professor, The Johns Hopkins

                      University School of Medicine, Departments of

                      Neuroscience, Pharmacology and Psychiatry

                      July 1976, Associate Professor, The Johns Hopkins

                      University School of Medicine, Departments of

                      Pharmacology and Psychiatry

                      October 1972, Assistant Professor, The Johns Hopkins

                      University School of Medicine, Departments of

                      Pharmacology and Psychiatry

                      October 1970, Postdoctoral Fellow, Yale University

                      School of Medicine, Department of Psychiatry and Basic Biological Sciences

Professional Societies:

American Association for the Advancement of Science (1969‑present; Honorary Fellow, 2018)

Society for Neuroscience (1973‑present; Nominating Committee, 1984‑1987; Presidential Symposium Speaker, 1990; Public Information Committee, 1996-1999; 

Social Issues Committee, 2003-2006; President, Atlanta Chapter, 2003-2004)

 American Society for Neurochemistry (1973‑1983; Program Committee, 1978; Organizer of Symposium on Neural Peptides, 1978)

 American Society for Pharmacology and Experimental Therapeutics (1974‑present; 2014 – 2023, Emeritus, Symposium Organizer at International Meeting, 1984; Selection Committee for Otto Krayer Award, 1993, 1997, 2002; and Neuropharmacology Division Executive Committee, 2002-2005, and Chair, 2003-2004; John Jacob Abel Award Committee, 2004-2007; Program Committee, 2006-2008; Neuropharmacology Division Nominating Committee, 2007)

  Mid‑Atlantic Acetylcholine Discussion Group (1973‑1978; Co‑Chairman, 1975)

   American College of Neuropsychopharmacology (Scientific Associate, 1978; Member, 1980; Fellow, 1986‑present; Member of Education and Training Committee, 1984‑1987; Program Committee,

        1988‑1990; Ethics Committee, 1991‑1993; Credentials Committee, 1993-1995; Animals in Research Committee, 2001-2004; Emeritus, 2013- present)

   International Brain Research Organization (IBRO) (1979‑present)

   International Drug and Alcohol Research Society (IDARS) (Member 2004-present; President, 2004-2008, Board of Directors 2004-2023)

   International Society of Addiction Journal Editors (ISAJE) (Member 2012 – 2016)

   College on Problems of Drug Dependence, Inc. (Member, 1994; Board of Directors, 1994-1998; Fellow, 1998; Executive Committee, 1999-2001; President, 1999-2000; Charter Member, 2006; Nominating Committee, 1994-1995; Publications Committee, 1994-1995; Media Relations Committee, Chair, 1994-1997; Long-Range Planning Committee, 2001-2004; Media Committee, 2001-2007; ONDCP Task Force, 2001-2003; Program Committee, 2013-2016, Awards Committee, 2016 -19)

 Neuroethics Society (2007 – 2018)

Professional Honors and Other Experience (Post BS Degree):

     Summer Program in Space Physics, Columbia University, 1965.

     Atomic Energy Commission Fellowship in Nuclear Physics, Harvard University, 1965-66.

    Graduate Fellowship, The Johns Hopkins Univ., Depts. Of Biophysics and Pharmacology, 1966-70.

    Phi Beta Kappa (1970), The Johns Hopkins University.

    Postdoctoral fellowship, Yale University 1970-1972.

                          National Institute of Mental Health Research Career Development Award, Type II (3/1/75 ‑ renewed 3/1/80 and 3/1/85)

                      National Institute of Mental Health Small Grants Committee (9/1/77‑8/31/81)

                      Distinguished Young Scientist in Maryland Award (1977, The Maryland Academy of Sciences)

    Visiting Scientist, National Institute for Medical Research, Mill Hill, London (Summer 1978; Molecular Pharmacology Unit, A.S.V. Burgen, Director)

                      Consultant, Pharmacology Department, Hoffman‑La Roche, 1980‑1985

                      Grass Traveling Scientist, spring 1981, to Halifax, Nova Scotia

                      Listed among "1,000 Contemporary Scientists Most Cited 1965‑1978", Current Contents 24, 5, 1981

                      Daniel H. Efron Award (1984, from the American College of Neuropsychopharmacology)

                      Mathilde Solowey Award for Research in Neuroscience, (1985 from the Foundation for Advanced

                             Education in the Sciences)

                      First Ariens Lecture (1985, The Dutch Pharmacological Society; DUPHAR)

                      Family Therapy Institute of Washington, DC, Part-time Family Therapy Training, 1983-1985.

                             Jay Haley and Cloe Madanes, Supervisors.  276 individual and group supervision hours.

                      Sterling Lecture (1987, Tufts Univ. School of Medicine; 1988, University of Kentucky Medical School)

                      Gold Lecture on Substance Abuse (1988, University of Florida Medical School at Gainesville)

                      Senior Executive Service Appointment (November 20, 1988, Dept. of Health & Human Services)

                      Administrator's Award for Meritorious Achievement (1989, ADAMHA)

                      Upjohn Lecture (1989, Uniformed Services University of the Health Sciences)

                      Thomas L. O'Donohue Memorial Lecture (1989, Howard University)

                      A. Ross McIntyre Award (1990, University of Nebraska Medical Center)

                      Presidential Symposium Lecturer (1990, Society for Neuroscience)

                      First Ivan F.W. Davidson Memorial Lecture (1990, Bowman Gray School of Medicine)

                      Distinguished Lecturer (1992, Stritch School of Medicine)

                      Otto Krayer Award (1992, American Society for Pharmacology and Experimental Therapeutics)

                      Harry Williams Lectureship Award (1992, Emory University School of Medicine)

                      Grass Lecture (1993, University of Kansas, MO)

                      Boots Distinguished Neuroscientist Lecture (1993, Louisiana State University Medical Center)

   Visiting Committee, Medical Department (1993-1997, Brookhaven National Laboratory)

  Consultant, Guilford Pharmaceuticals (1995)

                      Charles Howard Candler Professor (1995, Emory University)

                      Distinguished Lecturer (1996, University of South Alabama)

                      Eminent Scholar Award (1996, State of Georgia and Emory University)

                      Center for Brain Research (status appointment) Ege University, Turkey (1997- )

                      The Dana Alliance, Member (1997-2022)

  Advisory Board, Addiction Studies Institute, Wake Forest University (1999-2009)

                      President, College on Problems of Drug Dependence, Inc. (1999-2000)

                      Testified before a Congressional appropriations subcommittee supporting the NIH budget (03/2000)

   Invitation to White House on occasion of presenting the ONDCP policy on drugs (2/12/2002, and another time)

                      Scientific Advisory Board, Amethyst Technologies (1999-2000)

  Scientific Advisory Board, Addiction Therapies, Inc. (1999-2003)

                      NIDA K05 Senior Scientist Award (1999-2004; 2004-2009)

                        NIDA Special Emphasis Panels (member or chair, 1999-2008)

   Listed (by ISI) among the 250 most cited scientists in Neuroscience from 1981-2000 (rank 23rd)

   Scientific Advisory Board, Center for Psychiatric Neuroscience, Univ of Mississippi Med School (2000-2005)

   Director, Institutional Training Program in Drug Abuse, Emory University (2003-2014)

   NIDA K Study Section (Ad hoc, 2003-2004; regular member, 2004-2008)

   NIDA study sections, ad hoc member or chair (2008 – 2019).

   Board of Directors, Aptotec, Inc. (2004-2015)

   International Drug Abuse Research Society (IDARS) [First President (2004-2008)]

   Establishment of the annual Michael Kuhar Travel Award for trainees at IDARS meetings (2009)

   External Advisory Board, Center of Research Excellence in Natural Products Neuroscience, University of Mississippi at Oxford (2006-2022)

   Wendy and Stanley Marsh Lecture in Substance Abuse and Addictive Disorders, Texas Tech University Health Sciences Center, 2007

   Citations: about 75,000 lifetime citations (Research.com in 2023. https://research.com/scientists-rankings/biology-and-biochemistry)

   Fulbright Award for Catholic University in Chile, South America (2008)

   Teaching the Dalai Lama’s Tibetan Buddhist Monks and Nuns at Dharamsala, India, through the Emory-Tibet Science Initiative (summers, 2009-2011).

   Nathan B Eddy Award (for achievement in research, 2011, College on Problems of Drug Dependence)

   Journal of Drug and Alcohol Research, Ashdin Press, Founding Editor-in-Chief, (2012 - 2019)

   Gregory Bagby Distinguished Mentor lecture, LSU Med Sch (New Orleans), Dept Physiol, 4/2015.

   Advisory Board for PrayerSpark, Inc. (2015 - )

   Science Advisory Board, Chair, National Families in Action (2016 - 2023)

   Reviewer for Fulbright Fellowship applications (2017 - )

   Establishment of the “Michael Kuhar Neuroscience Travel Award” (competitive prize for trainees) by the Emory Primate Center of Emory University (December 2019)

   Board of Directors of “Loving Solutions Inc.”, a drug addiction treatment facility (May 2021).

   Pioneer Award, from Frontiers in Addiction Research and Pregnancy teaching program, (January 2022).

   Lifetime Achievement Award, International Drug and Alcohol Research Society (September 2022).

   Scientific Integrity Award, Emory Univ School of Medicine (October 2023).

Editorial Boards:

                      Advances in Drug and Alcohol Research                                           (2021 - )

                      Biochemical Pharmacology                                                                 (2004-2013)

                      Brain Research                                                                                       (1980‑1989)

                      Current Molecular Pharmacology                                                       (2008- 2020)

                      Current Opinion in Central and Peripheral Nervous Systems        (1998-2000)

                        Current Protocols in Pharmacology                                                        (1996-2001)

                      Drug and Alcohol Dependence                                                        (1995-2001)

                      Experimental and Clinical Psychopharmacology                             (1992-2000)

                      International Journal of Molecular Medicine                                     (1997-2013)

                      Journal of Chemical Neuroanatomy                                                   (1987‑2000)

                      Journal of Drug and Alcohol Research, Editor-in-Chief                  (2012-2019)

                      Journal of Neurochemistry                                                                   (1980‑1985)

                      Journal of Neuroscience                                                                       (1983‑1989)

                      Journal of Pharmacology and Experimental Therapeutics             (1993-2006)

                      Life Sciences                                                                                          (2003-2012)

                      Medical Hypotheses and Research                                                    (2003-2013)

                      Molecular and Cellular Neuroscience                                                (1990-1995)

                      Neurobiology of Aging                                                                          (1980‑1985)

                      NeuroImage                                                                                            (1991‑1995)

                      Neuropeptides                                                                                        (1980‑ 2011)

                      Neuropharmacology                                                                              (1980‑1992)

                      Neuropsychopharmacology                                                                 (1991‑1995)

                      Neuroscience-Net                                                                                  (1996- 2005)

                      Peptide Research                                                                                   (1989‑1994)

                      Peptides                                                                                                   (2007-2011)

                      Research Communications in Substances of Abuse                       (1991-1995)

                      Substance and Alcohol Misuse                                                            (1980-1985)

                      Synapse                                                                                                   (1992‑2008)

                      Trends in Neuroscience                                                                        (1982-1994)

                      The Open Ethics Journal                                                                      (2007- 2011)

                      Substance Abuse: Research and Treatment                                    (2007- 2012)

Seminar and Symposia invitations:

                      Dr Kuhar has presented more than 300 invited seminars, symposia lectures, and special and keynote lectures since 1972 when he became an Assistant Professor. For example, in the 14-year period between 1987 and 2001, 143 presentations were given, and in 2012, 17 presentations were given.  In 1980, 18 presentations were given. These invited presentations were made from various institutions from approximately 40 countries. The inviting institutions included Yale, Princeton, UCSF, Columbia, the NIH, Dupont Pharmaceuticals., and many others. There also were many lectures in symposia at major societies and special events in many countries.

SELECTED BOOKS AND VOLUMES

1.     Yamamura, H.I., Enna, S.J., and Kuhar, M.J. (Eds.). Neurotransmitter Receptor Binding. Raven Press, New York, 1978.

2.     Kuhar, M.J. and Pasternak, G.W. (Eds.). Analgesics: Neurochemical, Behavioral and Clinical Perspectives, Part of set in Neuropharmacology (S.J. Enna, Set Ed.). Raven Press, New York, 1984.

3.     Bjorklund, A., Hokfelt, T., and Kuhar, M.J. (Eds.). Handbook of Chemical Neuroanatomy, Vol. 3, Classical Transmitters and Transmitter Receptors in the CNS Part II.   Elsevier North‑Holland Biomedical Press, Amsterdam, 1985.

4.     Yamamura, H.I., Enna, S.J., and Kuhar, M.J. (Eds.). Methods in Neurotransmitter Receptor Analysis. Raven Press, New York, 1990.

5.     Rapaka, R.S., Makriyannis, A., and Kuhar, M.J. (Eds.). Emerging Technologies and New Directions in Drug Abuse Research, NIDA Research Monograph Series 112. U.S. Government Printing Office, Wash. DC, 1991.

6.     Jaffe, J.H., Anthony, J.C., Johanson, C.-E., Kuhar, M.J., Moore, M.H., and E.M. Sellers (Eds.). Encyclopedia of Drugs and Alcohol. Simon & Schuster Macmillan, New York, 1995.

7    Schuster, C.R. and Kuhar, M.J. (Eds.).  Pharmacological Aspects of Drug Dependence, Vol. 118, Handbook of Experimental Pharmacology. Springer-Verlag, New York, 1996.

8.   Kuhar, M.J. and Pogun, S. (Eds.).  Special Supplement Issue: Mathematical Modeling of Mental Disorders and        Processes. Neuropsychopharmacology 28(Suppl. 1): 2003.

9.         Kuhar, M.J. (Editor of Special Issue on CART Peptides). Peptides, Vol. 27, August. 2006.

10.  Sibley, D.R., Hanin, I., Kuhar, M., and Skolnick, P. (Eds). Handbook of Contemporary Neuropharmacology, Vols. 1-3. John Wiley & Sons, Hoboken, NJ, 2007.

11.       Ali, S.F. and Kuhar, M.J. (Eds). Drug Addiction: Research Frontiers and Treatment Advances, Ann N Y Acad Sci, Vol 1139, 2008.

12.       Kranzler, HR and Korsmeyer, P (Eds).  Kuhar MJ et al., (Assoc Eds.). Encyclopedia of Drugs, Alcohol, and Addictive Behavior, 3rd Edition.  MacMillan Reference USA, New York, 2009.

13.     Kuhar, MJ. The Addicted Brain: why we abuse drugs, alcohol, and nicotine. FT Press, Upper Saddle River, NJ, 2012. ISBN-10: 0-13-254250-1. Four printings of the hardback, many sales of softcover, and Translations into Korean, Japanese, Spanish, Chinese, and parts of book into Polish and Russian.

14.      Kuhar, MJ. The Addicted Brain. A MOOC (online course) by Coursera and Emory University.  First given on June 23, 2014, and continuing, https://www.coursera.org/course/addictedbrain, accessed on July 25, 2020. Expanded and edited in 2018.

15.  Kuhar, MJ. Research Ethics in the Life Sciences. Amazon.com. Self-Published. Second Edition. Oct 9, 2019, ISBN-13: 9781080760237. Third Edition. April, 2022, ISBN 9798413967607.

16.  Kuhar, MJ. The Art and Ethics of Being a Good Colleague. Amazon. First edition, 2016. Second Edition, April 1, 2020. ISBN-13: 978-1656762917.

17. Kuhar, MJ. The Addicted Brain: why we abuse drugs, alcohol, and nicotine. Second Edition, 2023, Amazon,  ISBN : 9798374305302.

18. Kuhar, MJ. Essays for Living. 2025, Amazon, ISBN : 9798315493075. 

PATENTS Issued

1. Carroll, F.I., Lewin, A.H., Abraham, P., Kuhar, M.J., and Boja, J.W.  Cocaine Receptor Binding Ligands.  Patent Number: 5,128,118.  July 7, 1992.

2. Uhl, G.R., Kuhar, M.J., Shimada, S., Kitayama, S., Patel, A., Lin, C.L.  cDNA Encoding a Dopamine Transporter and Protein Encoded Thereby.  Patent Number: 5,312,734.  May 17, 1994.

3. Kuhar, M.J., Boja, J.W., Carroll, F.I., Lewin, A.H., and Abraham, P. Cocaine Receptor Binding Ligands.  Patent Number: 5,380,848.  January 10, 1995.

4. Kuhar, M.J., Carroll, F.I., Boja, J.W., Lewin, A.H., and Abraham, P. Cocaine Receptor Binding Ligands.  Patent Number: 5,413,779.  May 9, 1995.

5. Kuhar, M.J., Carroll, F.I., Boja, J.W., Lewin, A.H., and Abraham, P. Cocaine Receptor Binding Ligands.  Patent Number: 5,496,953.  March 5, 1996.

6. Kuhar, M.J., Carroll, F.I., Boja, J.W., Lewin, A.H., and Abraham, P.  Methods for Controlling Invertebrate Pests Using Cocaine Receptor Binding Ligands.  Patent Number: 5,935,953.  August 10, 1999.

7. Carroll, F.I., Kuhar, M.J., Boja, J.W., Lewin, A.H., and Abraham, P.  Cocaine Receptor Binding Ligands.  Patent Number: 6,329,520.  December 11, 2001.

8. Kuhar, M.J., Carroll, F.I., Boja, J.W., Lewin, A.H., and Abraham, P.  Dopamine Transporter Imaging Ligand.  Patent Number: 6,358,492.  March 19, 2002.

9. Carroll, F.I., Kuhar, M.J., Boja, J.W., Lewin, A.H., and Abraham, P. Cocaine Receptor Binding Ligands.  Patent Number: 6,531,483.  March 11, 2003.

        10.     Carroll, F.I., Kuhar, M.J., Boja, J.W., Lewin, A.H., and Abraham, P.  Cocaine Receptor Binding Ligands.  Patent Number 6,706,880 B2.  March 16, 2004.

        11.     Kuhar, M.J., Carroll, F.I., Boja, J.W., Lewin, A.H., and Abraham, P. Cocaine Receptor Binding Ligands. Patent Number 7,011,813. March 14, 2006.

SELECTED REFEREED JOURNAL ARTICLES.

Dr Kuhar has published about 460 articles in refereed journals. These have generated more than 67,000 lifetime citations. This selected list shows typical publications from Dr Kuhar’s lab. A more complete list can be found at PubMed using the search term “Kuhar MJ.”

1.     Kuhar, M.J. and Snyder, S.H.  The Subcellular Distribution of Free 3H‑Glutamic Acid in Rat Cerebral Cortical Slices. J. Pharmacol. Exp. Ther. 171: 141‑152, 1970.

2.     Kuhar, M.J., Green, A.I., Snyder, S.H., and Gfeller, E.  Separation of Synaptosomes Storing Catecholamines and Gamma‑Aminobutyric Acid in Rat Corpus Striatum.  Brain Res. 21: 405‑417, 1970.

3.               Wofsey, A.R., Kuhar, M.J., and Snyder, S.H.  A Unique Synaptosomal Fraction, Which Accumulates Glutamic and Aspartic Acids in Brain Tissue.  Proc. Natl. Acad. Sci. (USA) 68: 1102‑1106, 1971.

4.               Kuhar, M.J., Roth, R.H., and Aghajanian, G.K.  Synthesis of Catecholamines in the Locus Coeruleus from 3H‑Tyrosine in vivo.  Biochem. Pharmacol. 21: 2280‑2282, 1972.

5.               Bustos, G., Kuhar, M.J., and Roth, R.H.  Effect of Gamma‑ Hydroxybutyrate on Dopamine Synthesis and Uptake by Rat Striatum.  Biochem. Pharmacol. 21: 2649‑2652, 1972.

6.               Aghajanian, G.K., Kuhar, M.J., and Roth, R.H.  Serotonin‑Containing Neuronal Perikarya and Terminals: Differential Effects of p‑Clorophenylalanine.  Brain Res. 54: 85‑101, 1973.

7.               Kuhar, M.J. and Aghajanian, G.K.  Selective Accumulation of 3H‑Serotonin by Nerve Terminals of Raphe Neurones: An autoradiographic Study.  Nature 241: 187‑189, 1973.

8.               Kuhar, M.J., Pert, C.B., and Snyder, S.H.  Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain.  Nature 245: 447‑450, 1973.

9.               Coyle, J.T. and Kuhar, M.J.  Subcellular Localization of Dopamine Beta‑Hydroxylase and Endogenous Norepinephrine in the Rat Hypothalamus.  Brain Res. 65: 475‑487, 1974.

10.            Kuhar, M.J. and Simon, J.R.  Acetylcholine Uptake: Lack of Association with Cholinergic Neurons.  J. Neurochem. 22: 1135‑1137, 1974.

11.            Mulder, A.H., Yamamura, H.K., Kuhar, M.J., and Snyder, S.H.  Release of Acetylcholine from Hippo­campal Slices by Potassium Depolarization: Dependence on High Affinity Choline Uptake.  Brain Res. 70: 372‑376, 1974.

12.            Rommelspacher, H., Goldberg, A.M., and Kuhar, M.J.  Action of Hemicholinium‑3 on Cholinergic Nerve Terminals After Alteration of Neuronal Impulse Flow.  Neuropharmacology 13: 1015‑1023, 1974.

13.            Yamamura, H.I., Kuhar, M.J., and Snyder, S.H.  In vivo Identification of Muscarinic Cholinergic Receptor Binding in Rat Brain.  Brain Res. 80: 170‑176, 1974.

14.            Rommelspacher, H. and Kuhar, M.J.  Effects of Dopaminergic Drugs and Acute Medial Forebrain Bundle Lesions on Striatal Acetylcholine Levels.  Life Sci. 16: 65‑70, 1975.

15.            Simon, J.R., Mittag, T.W., and Kuhar, M.J.  Inhibition of Synaptosomal Uptake of Choline by Various Choline Analogs.  Biochem. Pharmacol. 24: 1139‑1142, 1975.

16.            Kuhar, M.J. and Yamamura, H.I.  Light Autoradiographic Localization of Cholinergic Muscarinic Receptors in Rat Brain by Specific Binding of a Potent Antagonist.  Nature 253: 560‑561, 1975.

17.            Simon, J.R. and Kuhar, M.J.  Impulse‑Flow Regulation of High Affinity Choline Uptake in Brain Cholinergic Nerve Terminals.  Nature (London.) 255: 162‑163, 1975.

18.            Pert, C.B., Kuhar, M.J., and Snyder, S.H.  Autoradiographic Localization of the Opiate Receptor in Rat Brain.  Life Sci. 16: 1849‑1854, 1975.

19.            Enna, S.J., Kuhar, M.J., and Snyder, S.H.  Regional Distribution of Postsynaptic Receptor Binding for Gamma‑Aminobutyric Acid (GABA) in Monkey Brain.  Brain Res. 93: 168‑174, 1975.

20.            Bunney, B.S., Walters, J.R., Kuhar, M.J., Roth R.H., and Aghajanian, G.K.  D & L Amphetamine Stereoisomers: Comparative Potencies in Affecting the Firing of Central Dopaminergic and Noradrenergic Neurons.  Psychopharmacol. Comm. 1: 177‑190, 1975.

21.            Rommelspacher, H. and Kuhar, M.J.  Effects of Drugs and Axotomy on Acetylcholine Levels in Central Cholinergic Neurons.  Naunyn‑Schmiedeberg's Arch. Pharmacol. 291: 17‑21, 1975.

22.            Atweh, S., Simon, J.R., and Kuhar, M.J.  Utilization of Sodium‑Dependent High Affinity Choline Uptake in vitro as a Measure of the Activity of Cholinergic Neurons in vivo.  Life Sci. 17: 1535‑1544, 1975.

23.            Simantov, R., Kuhar, M.J., Pasternak, G.W., and Snyder, S.H.  The Regional Distribution of a Morphine-like Factor Enkephalin in Monkey Brain.  Brain Res. 106: 189‑197, 1976.

24.            Simon, J.R., Atweh, S., and Kuhar, M.J.   Sodium‑Dependent High Affinity Choline Uptake: A Regulatory Step in the Synthesis of Acetylcholine.  J. Neurochem. 26: 909‑922, 1976.

25.            Kuhar, M.J. and Yamamura, H.I.  Localization of Cholinergic Muscarinic Receptors in Rat Brain by Light Microscopic Radioautography.  Brain Res. 110: 229‑243, 1976.

26.            Simon, J.R. and Kuhar, M.J.   High Affinity Choline Uptake: Ionic and Energy Requirements.  J. Neurochem. 27: 93‑99, 1976.

27.            Pert, C.B., Kuhar, M.J., and Snyder, S.H.  Opiate Receptor: Autoradiographic Localization in Rat Brain.  Proc. Natl. Acad. Sci. (USA) 73: 3729‑3733, 1976.

28.            Murrin, L.C. and Kuhar, M.J.  Activation of High Affinity Choline Uptake in vitro by Depolarizing Agents.  Mol. Pharmacol. 12: 1082‑1090, 1976.

29.            Atweh, S.F. and Kuhar, M.J.  Autoradiographic Localization of Opiate Receptors in Rat. Brain.  I. Spinal Cord and Lower Medulla.  Brain Res. 124: 53‑67, 1977.

30.            Simantov, R., Kuhar, M.J., Uhl, G.R., and Snyder, S.H.  Opioid Peptide Enkephalin: Immuno­histo­chemical Mapping in Rat Central Nervous System.  Proc. Natl. Acad. Sci. (USA) 74: 2167‑2171, 1977.

31.            Atweh, S.F. and Kuhar, M.J.  Autoradiographic Localization of Opiate Receptors in Rat Brain. II. The Brain Stem.  Brain Res. 129: 1‑12, 1977.

32.            Atweh, S.F. and Kuhar, M.J.  Autoradiographic Localization of Opiate Receptors in Rat Brain. III. The Telencephalon.  Brain Res. 134: 393‑405, 1977.

33.            Uhl, G.R., Kuhar, M.J., and Snyder, S.H.  Neurotensin: Immunohisto‑chemical Localization in Rat Central Nervous System.  Proc. Natl. Acad. Sci. (USA) 74: 4059‑4063, 1977.

34.            Atweh, S.F., Murrin, L.C., and Kuhar, M.J.  Presynaptic Localization of Opiate Receptors in the Vagal and Accessory Optic System: An Autoradiographic Study.  Neuropharmacol. 17: 65‑71, 1978.

35.            Kuhar, M.J., Atweh, S.F., Murrin, L.C., and Simon, J.R.  Sodium‑Dependent High Affinity Choline Uptake: Its Significance and Practical Use.  Neuropsychopharmacologie 1(10): 469‑475, 1978.

36.            Kuhar, M.J., Murrin, L.C., Malouf, A.T., and Klemm, N.  Dopamine Receptor Binding in vivo: The Feasibility of Autoradiographic Studies.  Life Sci. 22: 203‑210, 1978.

37.            Murrin, L.C., Lewis, M.S., and Kuhar, M.J.  Amnio Acid Transport: Alterations Due to Synaptosomal Depolarization.  Life Sci. 22: 2009‑2016, 1978.

38.            Coyle, J.T., Molliver, M.E., and Kuhar, M.J.  In situ Injection of Kainic Acid:  A Method for Selectively Lesioning Neuronal Cell Bodies While Sparing Axons of Passage.  J. Comp. Neurol. 180: 301‑324, 1978.

39.            Kuhar, M.J. and Zarbin, M.A.  Synaptosomal Transport:  A Chloride Dependence for Choline, GABA, Glycine and Several Other Compounds.  J. Neurochem. 31: 251‑256, 1978.

40.            Uhl, G.R., Kuhar M.J., and Snyder, S.H.  Enkephalin‑Containing Pathway:  Amygdaloid Efferents in the Stria Terminalis.  Brain Res. 149: 223‑228, 1978.

41.            Kuhar, M.J., Mak, L.L., and Lietman, P.S.  Autoradiographic Localization of 3H‑Gentamycin in the Proximal Renal Tubules of Mice.  Antimicrob. Agents Chemother. 15: 131‑132, 1979.

42.            Uhl, G.R., Goodman, R.R., Kuhar, M.J., Childers S.R., and Snyder, S.H.  Immunohistochemical Mapping of Enkephalin‑Containing Cell Bodies, Fibers and Nerve Terminals in the Brain Stem of the Rat. Brain Res. 166: 75‑94, 1979.

43.            Klemm, N. and Kuhar, M.J.  Post‑mortem Changes in High Affinity Choline Uptake.  J. Neurochem. 32: 1487‑1494, 1979.

44.            Klemm, N., Murrin, L.C., and Kuhar, M.J.  Neuroleptic and Dopamine Receptors:  Autoradiographic Localization of 3H‑Spiperone in Rat Brain.  Brain Res. 169: 1‑9, 1979.

45.            Young, W.S., III, and Kuhar, M.J.  Autoradiographic Localization of Benzodiazepine Receptors in the Brain of Humans and Animals.  Nature 280: 393‑395, 1979.

46.            Young, W.S., III, and Kuhar, M.J.  Noradrenergic Alpha‑1 and Alpha‑2 Receptors:  Autoradiographic Visualization.  Eur. J. Pharmacol. 59: 317‑319, 1979.

47.            Young, W.S., III, and Kuhar, M.J.  A New Method for Receptor Autoradiography:  [3H]Opioid Receptors in Rat Brain.  Brain Res. 179: 255‑273, 1979.

48.            Niehoff, D.L., Palacios, J.M., and Kuhar, M.J.  In vivo Receptor Binding: Attempts to Improve Specific/ Non‑specific Ratios.  Life Sci. 25: 819‑826, 1979.

49.            Murrin, L.C., Gale, K., and Kuhar, M.J.  Autoradiographic Localization of Neuroleptic and Dopamine Recep­tors in the Caudate‑Putamen and Substantia Nigra: Effects of Lesions.  Eur. J. Pharmacol. 60: 229‑235, 1979.

50.            Palacios, J.M. and Kuhar, M.J.  Choline: Binding Studies Provide Some Evidence for a Weak, Direct Agonist Action in Brain.  Molec. Pharmacol. 16: 1084‑1088, 1979.

51.            Palacios, J.M., Young, W.S., III, and Kuhar, M.J.  Autoradiographic Localization of Gamma-aminobutyric (GABA) Receptors in Rat Cerebellum.  Proc. Natl. Acad. Sci. (USA) 77: 670‑674, 1980.

52.            Young, W.S., III, and Kuhar, M.J.  Noradrenergic Alpha‑1 and Alpha‑2 Receptors:  Light Microscopic Autoradiographic Localization.  Proc. Natl. Acad. Sci. (USA) 77: 1696‑1700, 1980.

53.            Young, W.S., III, and Kuhar, M.J.  Serotonin Receptor Localization in Rat Brain by Light Microscopic Autoradiography.  Eur. J. Pharmacol. 62: 237‑239, 1980.

54.            Wamsley, J.K., Young, W.S., III, and Kuhar, M.J.  Immunohisto‑chemical Localization of Enkephalin in Rat Forebrain.  Brain Res. 190: 153‑174, 1980.

55.            Palacios, J.M. and Kuhar, M.J.  Beta‑adrenergic Receptor Localization by Light Microscopic Autoradiography.  Science 208: 1378‑1380, 1980.

56.            Kuhar, M.J., Birdsall, N.J.M., Burgen, A.S.V. and Hulme, E.C.  Ontogeny of Muscarinic Receptors in Rat Brain.  Brain Res.  184: 375‑383, 1980.

57.            Young, W.S., III, Wamsley, J.K., Zarbin M.A., and Kuhar, M.J.  Opioid Receptors Undergo Axonal Flow.  Science 210: 76‑78, 1980.

58.            Murrin, L.C., Coyle, J.T., and Kuhar, M.J.  Striatal Opiate Receptors:  Pre‑ and Postsynaptic Localization.  Life Sci. 27: 1175‑1183, 1980.

59.            Batzold, F., DeHaven, R., Kuhar M.J., and Birdsall, N.  Inhibition of High Affinity Choline Uptake:  Structure Activity Studies.  Biochem. Pharmacol. 29: 2413‑2416, 1980.

60.            Wamsley, J.K., Zarbin, M.A., Birdsall, N.J.M., and Kuhar, M.J.  Muscarinic Cholinergic Receptors:  Autoradiographic Localization of High and Low Affinity Binding Sites.  Brain Res., 200: 1‑12, 1980.

61.            Goodman, R.R., Snyder, S.H., Kuhar, M.J., and Young, W.S., III.  Differentiation of Delta and Mu Opiate Receptor Localizations by Light Microscopic Autoradiography.  Proc. Natl. Acad. Sci. (USA) 77: 6239‑6243, 1980.

62.            Young, W.S., III, and Kuhar, M.J.  Alpha‑2 Adrenergic Receptors are Associated with Renal Proximal Tubules.  Eur. J. Pharmacol. 67: 493‑495, 1980.

63.            Wamsley, J.K., Lewis, M.S., Young, W.S., III, and Kuhar, M.J.  Autoradiographic Localization of Muscarinic Cholinergic Receptors in Rat Brainstem.  J. Neurosci. 1: 176-1912, 1981.

64.            Young, W.S., III, Niehoff, D.L., Kuhar, M.J., Beer B., and Lippa, A.S.  Multiple Benzodiazepine Recep­­tor Localization by Light Microscopic Radiohistochemistry. J. Pharmacol. Exp. Ther. 216: 425‑430, 1981.

65.            Palacios, J.M., Wamsley, J.K., and Kuhar, M.J.  The Distribution of Histamine‑H1 Receptors in the Rat Brain: An Autoradiographic Study.  Neuroscience 6: 15‑38, 1981.

66.            Palacios, J.M., Niehoff, D.L., and Kuhar, M.J.  [3H]‑Spiperone Binding Sites in Brain:  Autoradiographic Localization of Multiple Receptors.  Brain Res. 213: 277‑289, 1981.

67.            Zarbin, M.A., Wamsley, J.K., and Kuhar, M.J.  Glycine Receptor: Light Microscopic Autoradiographic Localization with [3H]‑Strychnine.  J. Neurosci. 1: 532‑547, 1981.

68.            Palacios, J.M., Kuhar, M.J., Rapoport S.I., and London, E.D.  Increases and Decreases in Local Cerebral Glucose Utilization in Response to GABA Agonists.  Eur. J. Pharmacol. 71: 333‑336, 1981.

69.            Kuhar, M.J., Taylor, N., Wamsley, J.K., Hulme, E.C., and Birdsall, N.J.M.  Muscarinic Cholinergic Receptor Localization in Brain by Electron Microscopic Autoradiography.  Brain Res. 216: 1‑10, 1981.

70.            Wamsley, J.K., Zarbin, M.A., and Kuhar, M.J.  Muscarinic Cholinergic Receptors Flow in the Sciatic Nerve.  Brain Res. 217: 155‑161, 1981.

71.            Zarbin, M.A., Wamsley, J.K., Innis R.B., and Kuhar, M.J.  Cholecystokinin Receptors:  Presence and Axonal Flow in the Rat Vagus Nerve.  Life Sci. 29: 697‑705, 1981.

72.            Palacios, J.M., Niehoff, D.L., and Kuhar, M.J.  Receptor Autoradiography with Tritium‑Sensitive Film:  Potential for Computerized Densitometry.  Neurosci. Lett. 25: 101‑105, 1981.

73.            Wamsley, J.K., Palacios, J.M., and Kuhar, M.J.  Autoradiographic Localization of Opioid Receptors in the Mammalian Retina.  Neurosci. Lett. 27: 19-24, 1981.

74.            Unnerstall, J.R., Kuhar, M.J., Niehoff, D.L., and Palacios, J.M.  Benzodiazepine Receptors are Coupled to a Subpopulation of Gamma-Aminobutyric Acid (GABA) Receptors: Evidence from a Quantitative Autoradiographic Study.  J. Pharmacol. Exp. Ther. 218: 797-804, 1981.

75.            Palacios, J.M. and Kuhar, M.J.  Neurotensin Receptors are Located on Dopamine‑Containing Neurons in Rat Midbrain.  Nature 294: 587‑589, 1981.

76.            Wamsley, J.K., Zarbin, M.A., Young, W.S., III, and Kuhar, M.J.  Distribution of Opiate Receptors in the Monkey Brain:  An Autoradiographic Study.  Neuroscience 7: 595‑613, 1982.

77.            Kuhar, M.J.  Receptors for Clonidine in Brain: Insights into Therapeutic Actions.  J. Clin. Psychiat. 43, 17‑19, 1982.

78.            Niehoff, D.L., Mashal, R.D., Horst, W.D., O'Brien, R.A., Palacios, J.M., and Kuhar, M.J.   Binding of a Radiolabeled Triazoloprydazine to a Subtype of Benzodiazepine Receptor in the Rat Cerebellum.  J. Pharmacol. Exp. Ther. 221: 670‑675, 1982.

79.            Kuhar, M.J. and Unnerstall, J.R.  In vitro Receptor Autoradiography: Loss of Label during Ethanol Dehydration and Preparative Procedures.  Brain Res. 244: 178‑181, 1982.

80.            Palacios, J.M., Kuhar, M.J., Rapoport, S.I., and London, E.D.  Effects of Gamma‑aminobutyric Acid and Antagonist Drugs on Local Cerebral Glucose Utilization.  J. Neurosci. 2: 853‑860, 1982.

81.            Zarbin, M.A., Wamsley, J.K., and Kuhar, M.J.  Axonal Transport of Muscarinic Cholinergic Receptors in Rat Vagus Nerve: High and Low Affinity Agonist Receptors Move in Opposite Directions and Differ in Nucleotide Sensitivity.  J. Neurosci. 2: 934‑941, 1982.

82.            Unnerstall, J.R., Niehoff, D.L., Kuhar, M.J., and Palacios, J.M.  Quantitative Receptor Autoradiog­raphy Using [3H]‑Ultrofilm: Application to Multiple Benzodiazepine Receptors.  J. Neurosci. Meth. 6: 59‑73, 1982.

83.            Unnerstall, J.R., Molliver, M.E., Kuhar, M.J., and Palacios, J.M.  Ontogeny of Opiate Binding Sites in the Hippocampus, Olfactory Bulb and Other Regions of the Rat Forebrain by Autoradiographic Methods.  Dev. Brain Res. 7: 157‑169, 1983.

84.            Whitehouse, P.J., Wamsley, J.K., Zarbin, M.A., Price, D.L., Tourtellotte, W.W., and Kuhar, M.J.  Amyotrophic Lateral Sclerosis: Alterations in Neurotransmitter Receptors.  Ann. Neurol. 14: 8‑16, 1983.

85.            Wagner, Jr., H.N., Burns, H.D., Dannals, R.F., Wong, D.F., Langstrom, B., Duelfer, T., Frost, J.J., Ravert, H.T., Links, J.M., Rosenbloom, S.B., Lukas, S.E., Kramer A.V., and Kuhar, M.J.  Imaging Dopamine Receptors in the Human Brain by Positron Tomography.  Science 221(4617): 1264‑1266, 1983.

86.            Zarbin, M.A., Palacios, J.M., Wamsley J.K., and Kuhar, M.J.  Axonal Transport of Beta‑Adrenergic Receptors: Antero‑ and Retrogradely Transported Receptors Differ in Agonist Affinity and Nucleotide Sensitivity.  Molec. Pharmacol. 24: 341‑348, 1983.

87.            Lo, M.M.S., Niehoff, D.L., Kuhar, M.J., and Snyder, S.H.  Autoradiographic Differentiation of Multiple Benzodiazepine Receptors by Detergent Solubilization and Pharmacologic Specificity.  Neurosci. Lett. 39: 37‑44, 1983.

88.            Niehoff, D.L., Mashal, R.D., and Kuhar, M.J.  Benzodiazepine Receptors:  Preferential Stimulation of Type 1 Receptors by Pentobarbital.  Eur. J. Pharmacol. 92: 131‑134, 1983.

89.            Niehoff, D.L. and Kuhar, M.J.  Benzodiazepine Receptors:  Localization in Rat Amygdala.  J. Neurosci. 3: 2091‑2097, 1983.

90.            Lo, M.M.S., Niehoff, D.L., Kuhar, M.J., and Snyder, S.H.  Differential Localization of Type I and II Benzodiazepine Binding Sites in Substantia Nigra.  Nature 306: 57‑60, 1983.

91.            Summers, R.J. and Kuhar, M.J.  Autoradiographic Localization of Alpha‑adrenoceptors in Rat Kidney.  Eur. J. Pharmacol. 91: 305‑310, 1983.

92.            Smith, G.T., Moran, T.H., Coyle, J.T., Kuhar, M.J., O'Donohue, T.L., and McHugh, P.R.  Anatomic Localization of Cholecystokinin Receptors to the Pyloric Sphincter.  Am. J. Physiol. 246: R127‑R130, 1984.

93.            Wagner, H.N., Jr., Burns, H.D., Dannals, R.F., Wong, D.F., Langstrom, B., Duelfer, T., Frost, J.J., Ravert, H.T., Links, J.M., Rosenbloom, S.B., Lukas, S.E., Kramer A.V., and Kuhar, M.J.  Assess­ment of Dopamine Receptor Densities in the Human Brain with Carbon‑11 Labeled N‑Methylspiperone.  Ann. Neurol. 15(Suppl.): S79‑S84, 1984.

94.            De Souza, E.B., Perrin, M.H., Rivier, J., Vale, W.W., and Kuhar, M.J.  Corticotropin‑Releasing Factor Receptors in Rat Pituitary Gland: Autoradiographic Localization. Brain Res. 296: 202‑207, 1984.

95.            Unnerstall, J.R., Kopajtic, T.A., and Kuhar, M.J.  Distribution of Alpha‑2 Agonist Binding Sites in the Rat and Human Central Nervous System: Analysis of Some Functional, Anatomical Correlates of the Pharmacologic Effects of Clonidine and Related Adrenergic Agents.  Brain Res. Rev. 7: 69‑101, 1984.

96.            Wamsley, J.K., Zarbin, M.A., and Kuhar, M.J. Distribution of Muscarinic Cholinergic High and Low Affinity Agonist Binding Sites: A Light Microscopic Autoradiographic Study.  Brain Res. Bull. 12: 233‑243, 1984.

97.            Uhl, G.R. and Kuhar, M.J.  Chronic Neuroleptic Treatment Enhances Neurotensin Receptor Binding in Human and Rat Substantia Nigra.  Nature 309: 350‑352, 1984.

98.            Whitehouse, P.J., Lynch, D., and Kuhar, M.J.  Effects of Postmortem Delay and Temperature on Neurotransmitter Receptor Binding in a Rat Model of the Human Autopsy Process.  J. Neurochem. 43: 553‑559, 1984.

99.            De Souza, E.B., Perrin, M.H., Insel, T.R., Vale W., and Kuhar, M.J.  Corticotropin‑Releasing Factor Receptors in Rat Forebrain: Autoradiographic Identification.  Science 224: 1449‑1451, 1984.

100.         De Souza, E.B. and Kuhar, M.J.  Dopamine Receptors in the Anterior Lobe of the Human Pituitary Gland: Autoradiographic Localization.  Brain Res. 306: 391‑395, 1984.

101.         Peroutka, S.J. and Kuhar, M.J.  Autoradiographic Localization of 5‑HT1 Receptors to Human and Canine Basilar Arteries.  Brain Res. 310: 193‑197, 1984.

102.         Wong, D.F., Wagner, H.N., Jr., Dannals, R.F., Links, J.M., Frost, J.J., Ravert, H.T., Wilson, A.A., Rosenbaum, A.E., Gjedde, A., Douglass, K.H., Petronis, J.D., Folstein, M.F., Thomas Toung, J.K., Burns H.D., and Kuhar, M.J.  Effects of Age on Dopamine and Serotonin Receptors Measured by Positron Tomography in the Living Human Brain.  Science 226: 1393‑1396, 1984.

103.         Lepor, H. and Kuhar, M.J.  Characterization and Localization of the Muscarinic Cholinergic Receptor in Human Prostatic Tissue.  J. Urol. 132: 397‑402, 1984.

104.         Lepor, H. and Kuhar, M.J.  Characterization of Muscarinic Cholinergic Receptor Binding in the Vas Deferens, Bladder, Prostate and Penis of the Rabbit.  J. Urol. 132: 392‑396, 1984.

105.         Burns, H.D., Dannals, R.F., Langstrom, B., Ravert, H.T., Zemyan, S.E., Duelfer, T., Wong, D.F., Frost, J.J., Kuhar, M.J., and Wagner, H.N., Jr.  (3‑N‑[11C]methyl)Spiperone, a Ligand Binding to Dopamine Receptors: Radiochemical Synthesis and Biodistribution Studies in Mice.  J. Nucl. Med. 25(11): 1222‑1227, 1984.

106.         Uhl, G.R., Whitehouse, P.J., Price, D.L., Tourtelotte, W.W., and Kuhar, M.J.  Parkinson's Disease: Depletion of Substantia Nigra Neurotensin Receptors.  Brain Res. 308: 186‑190, 1984.

107.         Summers, R.J., Stephenson, J.A., and Kuhar, M.J.  Localization of Beta‑Adrenoceptor Subtypes in Rat Kidney by Light Microscopic Autoradiography.  J. Pharmacol. Exp. Ther. 232: 561‑569, 1985.

108.         De Souza, E.B., Anholt, R.H., Murphy, K.M., Snyder, S.H., and Kuhar, M.J.  Peripheral‑Type Benzo­diazepine Receptors in Endocrine Organs: Autoradiographic Localization in Rat Pituitary, Adrenal, and Testis.  Endocrinology 116: 567‑573, 1985.

109.         Frost, J.J., Wagner, H.N., Jr., Dannals, R.F., Ravert, H.T., Links, J.M., Wilson, A.A., Burns, H.D., Wong, D.F., McPherson, R.W., Rosenbaum, A.E., Kuhar, M.J., and Snyder, S.H.  Imaging Opiate Receptors in the Human Brain by Positron Tomography.  J. Comput. Assist. Tomogr. 9: 231‑236, 1985.

110.         De Souza, E.B., Perrin, M.H., Whitehouse, P.J., Rivier, J., Vale, W., and Kuhar. M.J.  Corticotropin-Releasing Factor Receptors in Human Pituitary Gland: Autoradiographic Localization.  Neuroendo­crinology 40: 419‑422, 1985.

111.         Titeler, M., De Souza, E.B., and Kuhar, M.J.  [3H]Nitrendipine Binding to Calcium Channels in Bovine and Rat Pituitary.  J. Neurochem. 44(6): 1955‑1958, 1985.

112.         Inoue, Y., Wagner, H.N., Jr., Wong, D.F., Links, J.M., Frost, J.J., Dannals, R.F., Rosenbaum, A.E., Takeda, K., DiChiro, G., and Kuhar, M.J.  Atlas of Dopamine Receptor Images (PET) of the Human Brain.  J. Comput. Assist. Tomogr. 9: 129‑140, 1985.

113.         Whitehouse, P.J., Wamsley, J.K., Zarbin, M.A., Price D.L., and Kuhar, M.J.  Neurotransmitter Receptors in Amyotrophic Lateral Sclerosis: Possible Relationship to Sparing of Eye Movements (Letter to the Editor).  Ann. Neurol. 17: 518, 1985.

114.         De Souza, E.B., Insel, T.R., Perrin, M.H., Rivier, J., Vale, W.W., and Kuhar, M.J.  Differential Regulation of Corticotropin‑Releasing Factor in Anterior and Intermediate Lobes of Pituitary and in Brain Following Adrenalectomy in Rats.  Neurosci. Lett. 56: 121‑128, 1985.

115.         Wagner, H.N., Dannals, R.F., Frost, J.J., Wong, D.F., Ravert, H.T., Wilson, A.A., Links, J.M., Burns, H.D., Kuhar, M.J., and Snyder, S.H.  Imaging Neuroreceptors in the Human Brain in Health and Disease.  Radioisotopes 34: 103‑107, 1985.

116.         Goeders, N.E., Horst, W.D., O'Brien, R., Bautz, G., and Kuhar, M.J.  Benzodiazepine Receptor Binding with a New Ligand, Ro 22‑8515.  Eur. J. Pharmacol. 113: 147‑148, 1985.

117.         Millington, W.R., Aizenman, E., Bierkamper, G.G., Zarbin, M.A., and Kuhar, M.J.  Axonal Transport of Alpha‑Bungarotoxin Binding Sites in Rat Sciatic Nerve.  Brain Res. 340: 269‑276, 1985.

118.         Zarbin, M.A., Kuhar, M.J., O'Donohue, T.L., Wolf, S.S., and Moody, T.W.  Autoradiographic Localization of (125I‑TYR4) Bombesin‑Binding Sites in Rat Brain.  J. Neurosci. 5: 429‑437, 1985.

119.         Whitehouse, P.J., Trifiletti, R.R., Jones, B.E., Folstein, S., Price, D.L., Snyder, S.H., and Kuhar, M.J.  Neurotransmitter Receptor Alterations in Huntington's Disease: Autoradiographic and Homogenate Studies with Special Reference to Benzodiazepine Receptor Complexes.  Ann. Neurol. 18(2): 202‑210, 1985.

120.         Wong, D.F., Wagner, H.N., Jr., Pearlson, G., Dannals, R.F., Links, J.M., Ravert, H.T., Wilson, A.A., Suneja, S., Bjorvvinssen, E., Kuhar, M.J., and Tune, L.  Dopamine Receptor Binding of C‑11‑2‑N‑ Methylspiperone in the Caudate in Schizophrenia and Bipolar Disorder:  A Preliminary Report.  Psychopharmacol. Bull. 21(3): 595‑598, 1985.

121.         Zarbin, M.A., Wamsley, J.K., Palacios, J.M., and Kuhar, M.J.  Autoradiographic Localization of High Affinity GABA, Benzodiazepine, Dopaminergic, Adrenergic and Muscarinic Cholinergic Receptors in the Rat, Monkey and Human Retina.  Brain Res. 374: 75‑92, 1986.

122.         Wong, D.F., Wagner, H.N., Jr., Dannals, R.F., Links, J.M., Kuhar, M.J., and Gjedde, A.  Human Brain Receptor Distribution.  Science 232: 1269‑1271, 1986.

123.         Wong, D.F., Gjedde, A., Wagner, H.N., Jr., Dannals, R.F., Douglass, K.H., Links, J.M., and Kuhar, M.J.  Quantification of Neuroreceptors in the Living Human Brain, II. Inhibition Studies of Receptor Density and Affinity.  J. Cereb. Blood Flow Metab. 6: 147‑153, 1986.

124.         De Souza, E.B., Goeders, N.E., and Kuhar, M.J.  Benzodiazepine Receptors in Rat Brain are Altered by Adrenalectomy.  Brain Res. 381: 176‑181, 1986.

125.         De Souza, E.B., Whitehouse, P.J., Kuhar, M.J., Price, D.L., and Vale, W.W.  Reciprocal Changes in Corticotropin‑Releasing Factor (CRF)‑Like Immunoreactivity and CRF Receptors in Cerebral Cortex of Alzheimer's Disease.  Nature 319: 593‑595, 1986.

126.         Lyon, R.A., Titeler, M., Frost, J.J., Whitehouse, P.J., Wong, D.F., Wagner, H.N., Jr., Dannals, R.F., Links, J.M., and Kuhar, M.J.  3H‑3‑N‑Methylspiperone Labels D2 Dopamine Receptors in Basal Ganglia and S2 Serotonin Receptors in Cerebral Cortex.  J. Neurosci. 6(10): 2941‑2949, 1986.

127.         Wong, D.F., Wagner, H.N., Jr., Tune, L.E., Dannals, R.F., Pearlson, G.D., Links, J.M., Tamminga, C.A., Broussolle, E.P., Ravert, H.T., Wilson, A.A., Thomas Toung, J.K., Malat, J., Williams, J.A., O'Tuama, L.A., Snyder, S.H., Kuhar, M.J., and Gjedde, A.  Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug‑Naive Schizophrenics.  Science 234: 1558‑1563, 1986.

128.         Ko, G.N., Unnerstall, J.R., Kuhar, M.J., Wyatt, R.J., and Kleinman, J.E.  Lower α‑2 Agonist Binding Sites in Schizophrenic Brains.  Psychopharmacol. Bull. 22: 1011‑1016, 1986.

129.         Goeders, N.E. and Kuhar, M.J.  Chronic Cocaine Administration Induces Opposite Changes in Dopamine Receptors in the Striatum and Nucleus Accumbens.  Alcohol Drug Res. 7: 207‑216, 1987.

130.         Jampel, H.D., Lynch, M.G., Brown, R.H., Kuhar M.J., and De Souza, E.B.  ß‑Adrenergic Receptors in Human Trabecular Meshwork.  Invest. Ophthalmol. Vis. Sci. 28: 772‑779, 1987.

131.         Frost, J.J., Smith, A.C. , Kuhar, M.J., Dannals R.F., and Wagner H.N., Jr.  In vivo Binding of 3H‑N‑Methyl­spiperone to Dopamine and Serotonin Receptors.  Life Sci. 40: 987‑995, 1987.

132.         Ritz, M.C., Lamb, R.J., Goldberg S.R., and Kuhar, M.J.  Cocaine Receptors on Dopamine Transporters are Related to Self‑administration of Cocaine.  Science 237: 1219‑1223, 1987.

133.         Battaglia, G., Yeh, S.Y., O'Hearn, E., Molliver, M.E., Kuhar, M.J., and De Souza, E.B. 3,4‑Methylene­dioxymethamphetamine and 3,4‑Methylenedioxyamphetamine Destroy Serotonin Terminals in Rat Brain: Quantification of Neurodegeneration by Measurement of [3H]Paroxetine‑Labeled Serotonin Uptake Sites.  J. Pharmacol. Exp. Ther. 242: 911‑916, 1987.

134.         Whitehouse, P.J., Vale, W.W., Zweig, R.M., Singer, H.S., Mayeux, R., Kuhar, M.J., Price, D.L., and De Souza, E.B.  Reductions in Corticotropin‑Releasing Factor‑Like Immunoreactivity in Cerebral Cortex in Alzheimer's Disease, Parkinson's Disease, and Progressive Supranuclear Palsy.  Neurology 37: 9805‑909, 1987.

135.         Goeders, N.E., Ritz, M.C., and Kuhar, M.J.  Buspirone Enhances Benzodiazepine Receptor Binding in vivo.  Neuropharmacology 27: 275‑280, 1988.

136.         Sharkey, J., Glen, K.A., Wolfe, S., and Kuhar, M.J.  Cocaine Binding at Sigma Receptors.  Eur. J. Pharmacol. 149: 171‑174, 1988.

137.         O'Hearn, E., Battaglia, G., De Souza, E.B., Kuhar, M.J., and Molliver, M.E.  Methylenedioxy­amphetamine (MDA) and Methylenedioxymethamphetamine (MDMA) Cause Selective Ablation of Serotonergic Axon Terminals in Forebrain: Immunocytochemical Evidence for Neurotoxicity.  J. Neurosci. 8: 2788‑2803, 1988.

138.         Grigoriadis, D.E., Wilson, A.A., Lew, R., Sharkey, J.S., and Kuhar, M.J.  Dopamine Transport Sites Selectively Labeled by a Novel Photoaffinity Probe: 125I‑DEEP.  J. Neurosci. 9(8): 2664‑2670, 1989.

139.         Porrino, L.J., Ritz, M.C., Goodman, N.L., Sharpe, L.G., Kuhar, M.J., and Goldberg, S.R. Differential Effects of the Pharmacological Manipulation of Serotonin Systems on Cocaine and Amphetamine Self-administration in Rats.  Life Sci. 45: 1529‑1535, 1989.

140.         Sanchez-Roa, P.M., Grigoriadis, D.E., Wilson, A.A., Sharkey, J., Dannals, R.F., Villemagne, V.L., Wong, D.F., Wagner, H.N., and Kuhar, M.J.  [125]I‑Spectramide: A Novel Benzamide Displaying Potent and Selective Effects at the D2 Dopamine Receptor.  Life Sci. 45: 1821‑1829, 1989.

141.         Titeler, M., Lyon, R.A., Kuhar, M.J., Frost, J.F., Dannals, R.F., Leonhardt, S., Bullock, A., Rydelek, L.T., Price, D.L., and Struble, R.G.  Opiate Receptors are Selectively Labelled by [3H]-Carfentanil in Human and Rat Brain.  Eur. J. Pharmacol. 167: 221‑228, 1989.

142.         Boja, J.W. and Kuhar, M.J.  [3H]Cocaine Binding and Inhibition of [3H]-Dopamine Uptake is Similar in Both the Rat Striatum and Nucleus Accumbens.  Eur. J. Pharmacol. 173: 215‑217, 1989.

143.         Scheffel, U., Boja, J.W., and Kuhar, M.J.  Cocaine Receptors: In vivo Labeling With 3H‑(‑)Cocaine, 3H‑WIN 35,065‑2, and 3H‑WIN 35,428.  Synapse 4: 390‑392, 1989.

144.         Ritz, M.C., Cone, E.J., and Kuhar, M.J.  Cocaine Inhibition of Ligand Binding at Dopamine, Norepinephrine and Serotonin Transporters: A Structure‑Activity Study.  Life Sci. 46: 635‑645, 1990.

145.         Kuhar, M.J., Boja, J.W., and Cone, E.J.  Phencyclidine Binding to Striatal Cocaine Receptors.  Neuropharmacology 29: 295‑297, 1990.

146.         Zarbin, M.A., Wamsley, J.K., and Kuhar, M.J.  Anterograde Transport of Opioid Receptors in Rat Vagus Nerves and Dorsal Roots of Spinal Nerves: Pharmacology and Sensitivity to Sodium and Guanine Nucleotides.  Exp. Brain Res. 81: 267‑278, 1990.

147.         Ritz, M.C., Boja, J.W., Grigoriadis, D., Zaczek, R., Carroll, F.I., Lewis, A.H., and Kuhar, M.J.  [3H]WIN 35,065‑2: A Ligand for Cocaine Receptors in Striatum.  J. Neurochem. 55: 1556‑1562, 1990.

148.         Lew, R., Grigoriadis, D., Wilson, A.A., Boja, J.W., Simantov, R., and Kuhar, M.J.  Dopamine transporter: Deglycosylation with Exo‑ and Endo-glycosidases.  Brain Res. 539: 239‑246, 1991.

149.         Boja, J.W., Rahman, M.A., Abraham, P., Lewin, A.H., Carroll, F.I., and Kuhar, M.J.  Isothiocyanate Derivatives of Cocaine: Irreversible Inhibition of Ligand Binding at the Dopamine Transporter.  Mol. Pharmacol. 39: 339‑345, 1991.

150.         Carroll, F.I., Lewin, A.H., Philip, A., Parham, K., Boja, J.W., and Kuhar, M.J.   Synthesis and Ligand Binding of Cocaine Isomers at the Cocaine Receptor.  J. Med. Chem. 34: 883‑886, 1991.

151.         Boja, J.W., Patel, A., Carroll, F.I., Rahman, M.A., Philip, A., Lewin, A.H., and Kuhar, M.J.  [125I]RTI‑55: A Potent Ligand for Dopamine Transporters.  Eur. J. Pharmacol. 194: 133‑134, 1991.

152.         Lew, R., Vaughan, R., Simantov, R., Wilson, A., and Kuhar, M.J. Dopamine Transporters in the Nucleus Accumbens and the Striatum Have Different Apparent Molecular Weights.  Synapse 8: 152‑153, 1991.

153.         Scheffel, U., Pögün, S., Stathis, M., Boja, J.W., and Kuhar, M.J.  In vivo Labeling of Cocaine Binding Sites on Dopamine Transporters with [3H]WIN 35,428. J. Pharmacol. Exp. Ther. 257(3): 954‑958, 1991.

154.         Shimada, S., Kitiyama, S., Lin, C.-L., Patel, A., Nanthakumar, E., Gregor, P., Kuhar, M.J., and Uhl, G. Cloning and Expression of a Cocaine‑Sensitive Dopamine Transporter Complementary DNA.  Science, 254: 576‑578, 1991.

155.         Kuhar, M.J., Lloyd, D.G., Appel N and Loats, H.L.  Imaging Receptors by Autoradiography: Computer‑Assisted Approaches.  J. Chem. Neuroanat. 4: 319‑327, 1991.

156.         Vaughan, R.A., Simantov, R., Lew, R., and Kuhar, M.J.  A Rapid Binding Assay for Solubilized Dopamine Transporters Using [3H]WIN 35,428.  J. Neurosci. Meth. 40: 9-16, 1991.

157.         Carroll, F.I., Rahman, M.A., Abraham, P., Parham, K., Lewin, A.H., Dannals, R.F., Shaya, E., Scheffel, U., Wong, D.F., Boja, J.W., and Kuhar, M.J.  [123I]3b‑(4‑Iodophenyl)Tropan‑2b‑Carboxylic Acid Methyl Ester (RTI‑55), A Unique Cocaine Receptor Ligand for Imaging the Dopamine and Serotonin Transporters in vivo.  Med. Chem. Res. 1: 289-294, 1991.

158.         Lewin, A.H., Gao, Y., Abraham, P., Boja, J.W., Kuhar M.J., and Carroll, F.I.   2b-Substituted Analogues of Cocaine.  Synthesis and Inhibition of Binding to the Cocaine Receptor.  J. Med. Chem. 35: 135-140, 1992.

159.         Abraham, P., Pitner, J.B., Lewin, A.H., Boja, J.W., Kuhar, M.J., and Carroll, F.I. N-Modified Analogues of Cocaine: Synthesis and Inhibition of Binding to the Cocaine Receptor.  J. Med. Chem. 35: 141-144, 1992.

160.         Shaya, E.K., Scheffel, U., Dannals, R.F., Racaurte, G.A., Carroll, F.I., Wagner, H.N., Jr., Kuhar, M.J., and Wong, D.F.  In vivo Imaging of Dopamine Reuptake Sites in the Primate Brain Using Single Photon Emission Computed Tomography (SPECT) and Iodine-123 Labeled RTI-55.  Synapse 10: 169-172, 1992.

161.         Cline, E.J., Scheffel, U., Boja, J.W., Carroll, F.I., Katz, J.L., and Kuhar, M.J.  Behavioral Effects of Novel Cocaine Analogs:  A Comparison with in vivo Receptor Binding Potency.  J. Pharmacol. Exp. Ther. 260: 1174-1179, 1992.

162.         Patel, A., Boja, J.W., Lever, J., Lew, R., Simantov, R., Carroll, F.I., Lewin, A.H., Philip, A., Gao, Y., and Kuhar, M.J.  A Cocaine Analog and a GBR Analog Label the Same Protein in Rat Striatal Membranes.  Brain Res. 576: 173-174, 1992. 

163.         Cline, E.J., Terry, P., Carroll, F.I., Kuhar, M.J., and Katz, J.L.  Stimulus Generalization from Cocaine to Analogs with High in vitro Affinity for Dopamine Uptake Sites. Behav. Pharmacol. 3: 113-116, 1992.

164.         Scheffel, U., Dannals, R.F., Cline, E.J., Ricaurte, G.A., Carroll, F.I., Abraham, P., Lewin, A.H., and Kuhar, M.J.  [123/125I]RTI-55, an in vivo Label for the Serotonin Transporter.  Synapse 11: 134-139, 1992.

165.         Carroll, F.I., Gao, Y., Abraham, P., Lewin, A.H., Lew, R., Patel, A., Boja, J.W., and Kuhar, M.J.  Probes for the Cocaine Receptor.  Potentially Irreversible Ligands for the Dopamine Transporter.  J. Med. Chem. 35: 1813-1817, 1992.

166.         Lew, R., Patel, A., Vaughan, R., Wilson, A., and Kuhar, M.J.  Microheterogeneity of Dopamine Transporters in Rat Striatum and Nucleus Accumbens.  Brain Res. 584: 266-271, 1992.

167.         Boja, J.W., Mitchell, W.M., Patel, A., Kopajtic, T.A., Carroll, F.I., Lewin, A.H., Abraham, P., and Kuhar, M.J.  High-Affinity Binding of [125I]RTI-55 to Dopamine and Serotonin Transporters in Rat Brain.  Synapse 12: 27-36, 1992.

168.         Rostene, W., Boja, J.W., Scherman, D., Carroll, F.I., and Kuhar, M.J.  Dopamine Transport: Pharmaco­logical Distinction between the Synaptic Membrane and the Vesicular Transporter in Rat Striatum.  Eur. J. Pharmacol. 218: 175-177, 1992.

169.         Scheffel, U., Dannals, R.F., Wong, D.F., Yokoi, F., Carroll, F.I., and Kuhar, M.J.  Dopamine Transporter Imaging with Novel, Selective Cocaine Analogs.  NeuroReport 3: 969-972, 1992.

170.         Vaughan, R.A., Uhl, G., and Kuhar, M.J.  Recognition of Dopamine Transporters by Antipeptide Antibodies.  Mol. Cell. Neurosci. 4: 209-215, 1993.

171.         Cerruti, C., Walther, D.M., Kuhar, M.J. and Uhl, G.R.  Dopamine Transporter mRNA Expression is Intense in Rat Midbrain Neurons and Modest Outside Midbrain.  Mol. Brain Res. 18: 181-186, 1993.

172.         Wong, D.W., Yung, B., Dannals, R.F., Shaya, E.S., Ravert, H.T., Chen, C.A., Chan, B., Folio, T., Scheffel, U., Ricaurte, G., Neumeyer, J.L., Wagner, H.N. Jr., and Kuhar, M.J.  In vivo Imaging of Baboon and Human Dopamine Transporters by Positron Emission Tomography Using [11C]WIN 35,428.  Synapse 15: 130-142, 1993.

173.         Brouard, A., Pelaprat, D., Boja, J.W., Carroll, F.I., Vial, M., Kuhar, M.J., and Rostene, W.  Potent Cocaine Analogs Inhibit [3H]-Dopamine Uptake in Rat Mesencephalic Cells in Primary Cultures: Pharma­cological Selectivity of Embryonic Cocaine Sites.  Dev. Brain Res. 75: 13-17, 1993. 

174.         Cerruti, C., Pilotte, N.S., Uhl, G., and Kuhar, M.J.  Reduction in Dopamine Transporter mRNA after Cessation of Repeated Cocaine Administration.  Mol. Brain Res. 22: 132-138, 1994.

175.         Pögün, S., Baumann, M.H., and Kuhar, M.J.  Nitric Oxide Inhibits [3H]-Dopamine Uptake.  Brain Res. 641: 83-91, 1994.

176.         Scheffel, U., Kim, S., Cline, E.J., and Kuhar, M.J.  Occupancy of the Serotonin Transporter by Fluoxetine, Paroxetine, and Sertraline: In vivo Studies with [125I] RTI-55. Synapse 16: 263-268, 1994.

177.         Boja, J.W., Kuhar, M.J., Kopajtic, T., Yang, E., Abraham, P., Lewin, A.H., and Carroll, M.J.  Secondary Amine Analogues of 3b-(4'-Substituted phenyl)tropan-2b-carboxylic Acid Esters and N-Norco­caine Exhibit Enhanced Affinity for Serotonin and Norepinephrine Transporters.  J. Med. Chem. 37(18):  1220-1223, 1994.

178.         Pilotte, N.S., Sharpe, L.G., and Kuhar, M.J.  Withdrawal of Repeated Intravenous Infusions of Cocaine Persistently Reduces Binding to Dopamine Transporters in the Nucleus Accumbens of Lewis Rats.  J. Pharmacol. Exp. Ther. 260: 963-969, 1994.

179.         Pögün, S., Dawson, V., and Kuhar, M.J.  Nitric Oxide Inhibits 3H-Glutamate Transport in Synapto­somes. Synapse 18: 21-26, 1994.

180.         Brown, D.J., Luthra, S.K., Brown, G.D., Carroll, F.I., Kuhar, M.J., Osman, S., Waters, S.L., and Brady, F.  [11C]RTI-121 - A Potential Radioligand for PET Studies of the Dopamine Transporter.  J. Labelled Compd. Radiopharmaceut. 35: 483, 1994.

181.         Volkow, N.D., Gatley, S.J. Fowler, J.S., Chen, R., Logan, J., Dewey, S.L., Ding, Y.-S., Pappas, N., King, P., MacGregor, R.R., Kuhar, M.J., Carroll, F.I. and Wolf, A.P. Long-Lasting Inhibition of in vivo Cocaine Binding to Dopamine Transporters by 3b-(4-Iodophenyl)Tropane-2-Carboxylic Acid Methyl Ester: RTI-55 or bCIT.  Synapse 19(3): 206-211, 1995.

182.         Freed, C., Revay, R., Vaughan, R.A., Kriek, E., Grant, S., Uhl, G.R., and Kuhar, M.J.  Dopamine Transporter Immunoreactivity in Rat Brain.  J. Comp. Neurol., 359: 340-349, 1995.

183.         Kotian, P., Abraham, P., Lewin, A.H., Mascarella, S.W., Boja, J.W., Kuhar, M.J., and Carroll, F.I.  Synthesis and Ligand Binding Study of 3b-(4'-Substituted phenyl)-2b-(heterocyclic)tropanes.  J. Med. Chem., 38(18): 3451-3453, 1995.

184.         Scheffel, U., Taylor, G.F., Kepler, J.A., Carroll, F.I., and Kuhar, M.J.  In vivo Labeling of Neuronal Nicotinic Acetylcholine Receptors with Radiolabeled Isomers of Norchloroepibatidine.  Neuro­Report 6: 2483-2488, 1995.

185.         Stathis, M., Scheffel, U., Lever, S.Z., Boja, J.W., Carroll, F.I., and Kuhar, M.J.  Rate of Binding of Various Inhibitors at the Dopamine Transporter in vivo.  Psychopharmacology, 119: 376-384, 1995.

186.         Pilotte, N.S., Sharpe, L.G., Rountree, S.D., and Kuhar, M.J.  Cocaine Withdrawal Reduces Dopamine Transporter Binding in the Shell of the Nucleus Accumbens.  Synapse 22: 87-92, 1996.

187.         Nirenberg, M.J., Vaughan, R.A., Uhl, G.R., Kuhar, M.J., and Pickel, V.M.  The Dopamine Transporter is Localized to Dendritic and Axonal Plasma Membranes of Nigrostriatal Dopaminergic Neurons.  J. Neurosci. 16(2): 436-447, 1996.

188.         Gatley, S.J., Volkow, N.D., Chen, R., Fowler, J.S., Carroll, F.I., and Kuhar, M.J.  Displacement of RTI-55 from the Dopamine Transporter by Cocaine.  Eur. J. Pharmacol. 296: 145-151, 1996.

189.         Lever, J.R., Scheffel, U., Stathis, M., Seltzman, H.H., Wyrick, C.D., Abraham, P., Parham, K., Thomas, B.F., Boja, J.W., Kuhar, M.J., and Carroll, F.I.  Synthesis and in vivo Studies of a Selective Ligand for the Dopamine Transporter:  3b-(4-[125I]Iodophenyl) Tropan-2b-Carboxylic Acid Isopropyl Ester ([125I]RTI-121). Nuclear Med Biol. 23: 277-284,1996.

190.         Vaughan, R.A., Brown, V.L., McCoy, M.T., and Kuhar, M.J.  Species- and Brain Region-Specific Dopamine Transporters: Immunological and Glycosylation Characteristics. J. Neurochem. 66: 2146-2152, 1996.

191.         Hume, S.P., Luthra, S.K., Brown, D.J., Opacka-Juffry, J., Osman, S., Ashworth, S., Myers, R., Brady, F., Carroll, F.I., Kuhar, M.J., and Brooks, D.J.  Evaluation of [11C]RTI-121 as a Selective Radioligand for PET Studies of the Dopamine Transporter.  Nucl. Med. Biol. 23: 377-384, 1996.

192.         Fleckenstein, A.E., Kopajtic, R.A., Boja, J.W., Carroll, F.I. and Kuhar, M.J.  Highly Potent Cocaine Analogs Cause Long-Lasting Increases in Locomotor Activity.  Eur. J. Pharmacol. 311: 109-114, 1996.

193.         Vaughan, R.A. and Kuhar, M.J.  Dopamine Transporter Ligand Binding Domains.  J. Biol. Chem. 271: 21672-21680, 1996.

194.         Blough, B.E., Abraham, P., Lewin, A.H., Kuhar, M.J., Boja, J.W. and Carroll, F.I.  Synthesis and Transporter Binding Properties of 3b-(4'-Alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2b-carboxylic Acid Methyl Esters: Serotonin Transporter Selective Analogs.  J. Med. Chem. 39: 4027-4035, 1996.

195.         Holmquist, C.R., Keverline-Frantz, K.I., Abraham, P., Boja, J.W., Kuhar, M.J. and Carroll, F.I.3a-(4'-Substituted phenyl)tropane-2b-carboxylic Acid Methyl Esters: Novel Ligands with High Affinity and Selectivity at the Dopamine Transporter.  J. Med. Chem. 39: 4139-4141, 1996.

196.         Ding. Y.-S., Gatley, S.J., Fowler, J.S., Volkow, N.D., Aggarwal, D., Logan, J., Dewey, S.L., Liang, F., Carroll, F.I. and Kuhar, M.J.  Mapping Nicotinic Acetylcholine Receptors with PET.  Synapse 24: 403-407, 1996.

197.         Wong, D.F., Harris, J.C., Naidu, S., Yokoi, F., Marenco, S., Dannals, R.F., Ravert, H.T., Yaster, M., Evans, A., Rousset, O., Bryan, R.N., Gjedde, A., Kuhar, M.J. and Breese, G.R.   Dopamine Transporters are Markedly Reduced in Lesch-Nyhan Disease in vivo.  Proc. Natl. Acad. Sci. USA 93: 5539-5543, 1996.

198.         Fleckenstein, A.E., Pögün, S., Carroll, F.I., and Kuhar, M.J.  Recovery of Dopamine Transporter Binding and Function after Intrastriatal Administration of the Irreversible Inhibitor RTI-76 {3b-(3r-Chlorophenyl)Tropan-2b-Carboxylic Acid r-Isothiocyanatophenylethyl Ester Hydrochloride}.  J. Pharmacol. Exp. Ther. 279: 200-206, 1996.

199.         Huff, R.A., Vaughan, R.A., Kuhar, M.J., and Uhl, G.R.  Phorbol Esters Increase Dopamine Transporter Phosphorylation and Decrease Transport Vmax.  J. Neurochem. 68: 225-232, 1997.

200.         Vaughan, R.A., Huff, R.A., Uhl, G.R., and Kuhar, M.J.  Protein Kinase C-mediated Phosphorylation and Func­tional Regulation of Dopamine Transporters in Striatal Synaptosomes.  J. Biol. Chem. 272: 15541-15546, 1997.

201.         Thiruvazhi, M., Abraham, P., Kuhar, M.J., and Carroll, F.I.  Synthesis of the Isomers of (1R)-3-(Pheny­lthio)Tropane-2-Carboxylic Acid Methyl Ester. A New Class of Ligands for the Dopamine Transporter.  Chem. Commun: 555-556, 1997.

202.         Nirenberg, M.J., Chan, J., Vaughan, R.A., Uhl, G.R., Kuhar, M.J., and Pickel, V.M.  Immunogold Localization of the Dopamine Transporter: An Ultrastructural Study of the Rat Ventral Tegmental Area.  J. Neurosci. 17(14): 5255-5262, 1997.

203.         Smith, Y., Koylu, E.O., Couceyro, P., and Kuhar, M.J.  Ultrastructural Localization of CART (Cocaine- and Amphetamine-Regulated Transcript) Peptides in the Nucleus Accumbens of Monkeys.  Synapse 27: 90-94, 1997.

204.         Couceyro, P.R., Koylu, E.O., and Kuhar, M.J.  Further Studies on the Anatomical Distribution of CART by in situ Hybridization.  J. Chem. Neuroanat. 12: 229-241, 1997.

205.         Ding, Y.-S., Liang, F., Fowler, J.S., Kuhar, M.J., and Carroll, F.I.  Synthesis of [18F]Norchlorofluoro­epibatidine and its N-methyl Derivative: New PET Ligands for Mapping Nicotinic Acetylcholine Receptors.  J. Labelled Compd. Radiopharmaceut. 39(10): 827-832, 1997.

206.         Nirenberg, M.J., Chan, J., Pohorille, A., Vaughan, R.A., Uhl, G.R., Kuhar, M.J. and Pickel, V.M.  The Dopamine Transporter: Comparative Ultrastructure of Dopaminergic Axons in Limbic and Motor Compart­ments of the Nucleus Accumbens.  J. Neurosci. 17: 6899-6907, 1997.

207.         Koylu, E.O., Couceyro, P.R., Lambert, P.D., Ling, N.C., DeSouza, E.B., and Kuhar, M.J.  Immuno­histochemical Localization of Novel CART Peptides in Rat Hypothalamus, Pituitary and Adrenal Gland.  J. Neuroendocrinol. 9: 823-833, 1997.

208.         Koylu, E.O., Couceyro, P.R., Lambert, P.D., and Kuhar, M.J.  Cocaine- and Amphetamine-Regulated Transcript Peptide Immunohistochemical Localization in the Rat Brain. J. Comp. Neurol. 391: 115-132, 1998.

209.         Persico, A.M., Reich, S., Henningfield, J.E., Kuhar, M.J., and Uhl, G.R. Parkinsonian Patients Report Blunted Subjective Effects of Methylphenidate.  Exp. Clin. Psychopharmacol. 6: 54-63, 1998.

210.         Houlihan, W.J., Boja, J.W., Kopajtic, T.A., Kuhar, M.J., Degrado, S.J., and Toledo, L.  Positional Isomers and Analogs of Mazindol as Potential Inhibitors of the Cocaine Binding Site on the Dopamine Transporter Site.  Med. Chem. Res. 8(1/2): 77-90, 1998.

211.         Lambert, P.D., Couceyro, P.R., McGirr, K.M., Dall Vechia, S.E., Smith, Y., and Kuhar, M.J.  CART Peptides in the Central Control of Feeding and Interactions with Neuropeptide Y.  Synapse 29: 293-298, 1998.

212.         Boja, J.W., Carroll, F.I., Vaughan, R.A., Kopajtic, T., and Kuhar, M.J.  Multiple Binding Sites for [125I]RTI-121 and Other Cocaine Analogs in Rat Frontal Cerebral Cortex.  Synapse 30: 9-17, 1998.

213.         Dworkin, S.I., Lambert, P., Sizemore, G.M., Carroll, F.I., and Kuhar, M.J.  RTI-113 Administration Reduces Cocaine Self-administration at High Occupancy of Dopamine Transporter.  Synapse 30: 49-55, 1998.

214.         Elias, C.F., Lee, C., Kelly, J., Aschkenasi, C., Ahima, R.S., Couceyro, P.R., Kuhar, M.J., Saper, C.B., and Elmquist, J.K.  Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord.  Neuron 21: 1375-1385, 1998.

215.         Smith, Y., Kieval, J., Couceyro, P.R., and Kuhar, M.J. CART Peptide-Immunoreactive Neurones in the Nucleus Accumbens in Monkeys: Ultrastructural Analysis, Colocalization Studies, and Synaptic Inter­actions with Dopaminergic Afferents.  J. Comp. Neurol. 407: 491-511, 1999.

216.         Lambert, P.D., McGirr, K.M., Ely, T.D., Kilts, C.D., and Kuhar, M.J.  Chronic Lithium Treatment Decreases Neuronal Activity in the Nucleus Accumbens and Cingulate Cortex of the Rat. Neuropsycho­pharmacology 21: 229-237, 1999.

217.         Garzón, M., Vaughan, R.A., Uhl, G.R., Kuhar, M.J., and Pickel, V.M.  Cholinergic Axon Terminals in the Ventral Tegmental Area Target a Subpopulation of Neurons Expressing Low Levels of the Dopamine Transporter.  J. Comp. Neurol. 410: 197-210, 1999.

218.         Kuhar, M.J. and Yoho, L.L.  CART Peptide Analysis by Western Blotting.  Synapse 33: 163-171, 1999.

219.         Vicentic, A., Battaglia, G., Carroll, F.I., and Kuhar, M.J.  Serotonin Transporter Production and Degradation Rates: Studies with RTI-76.  Brain Res. 841: 1-10, 1999.

220.         Broberger, C., Holmberg, K., Kuhar, M.J., and Hökfelt, T.  Cocaine- and Amphetamine-Regulated Transcript in the Rat Vagus Nerve: A Putative Mediator of Cholecystokinin-Induced Satiety.  Proc. Natl. Acad. Sci. USA  96: 13506-13511, 1999.

221.         Broberger, C., Visser, T.J., Kuhar, M.J., and Hökfelt, T.  Neuropeptide Y Innervation and Neuropeptide-Y-Y1-Receptor-Expressing Neurons in the Paraventricular Hypothalamic Nucleus of the Mouse.  Neuroendocrinology 70: 295-305, 1999.

222.         Howell, L.L., Czoty, P.W., Kuhar, M.J., and Carroll, F.I.  Comparative Behavioral Pharmacology of Cocaine and the Selective Dopamine Uptake Inhibitor RTI-113 in the Squirrel Monkey.  J. Pharmacol. Exp. Ther. 292: 521-529, 2000.

223.         Kimmel, H.L., Carroll, F.I., and Kuhar, M.J.:  Dopamine Transporter Synthesis and Degradation Rate in Rat Striatum and Nucleus Accumbens Using RTI-76.  Neuropharmacology 39: 578-585, 2000.

224.         Koylu, E.O., Weruaga, E., Balkan, B., Alonso, J.R., Kuhar, M.J., and Pogun, S.  Co-localization of CART Peptide Immunoreactivity and Nitric Oxide Synthase Activity in Rat Hypothalamus.  Brain Res. 868: 352-357, 2000.

225.         Kimmel, H.L., Gong, W., Dall Vechia, S., Hunter, R.G., and Kuhar, M.J.  Intra-ventral Tegmental Area Injection of Rat Cocaine and Amphetamine-Regulated Transcript Peptide 55-102 Induces Locomotor Activity and Promotes Conditioned Place Preference.  J. Pharmacol. Exp. Ther. 294: 784-792, 2000.

226.         Blough, B.E., Holmquist, C.R., Abraham, P., Kuhar, M.J., and Carroll, F.I.  3a-(4-Substituted Phenyl) nortropane-2-ß-carboxylic Acid Methyl Esters Show Selective Binding at the Norepinephrine Transporter.  Bioorg. Med. Chem. Lett. 10: 2445-2447, 2000.

227.         Murphy, K.G., Abbott, C.R., Mahmoudi, M., Hunter, R., Gardiner, J.V., Rossi, M., Stanley, S.A., Ghatei, M.A., Kuhar, M.J., and Bloom, S.R.  Quantification and Synthesis of Cocaine- and Amphetamine-Regulated Transcript Peptide (79-102)-like Immunoreactivity and mRNA in Rat Tissues.  J. Endocrinol. 166: 659-668, 2000.

228.         Johansen, J.E., Broberger, C., Lavebratt, C., Johansson, C., Kuhar, M.J., Hökfelt, T., and Schalling, M. Hypothalamic CART and Serum Leptin Levels are Reduced in the Anorectic (anx/anx) Mouse.  Mol. Brain Res. 84: 97-105, 2000.

229.         Dall Vechia-Adams, S., Smith, Y., and Kuhar, M.J.  CART Peptide-Immunoreactive Projection from the Nucleus Accumbens Targets Substantia Nigra Pars Reticulata Neurons in the Rat.  J. Comp. Neurol. 434: 29-39, 2001.

230.         Kuhar, M.J., Joyce, A., and Dominguez, G.  Genes in Drug Abuse.  Drug Alcohol Depend. 62: 157-162, 2001.

231.         Elias, C.F., Lee, C.E., Kelly, J.F., Ahima, R.S., Kuhar, M., Saper, C.B., and Elmquist, J.K. Characteri­zation of CART Neurons in the Rat and Human Hypothalamus.  J. Comp. Neurol. 432: 1-19, 2001.

232.         Kuhar, M.J., Carroll, F.I., Bharat, N., and Landry, D.W.  Anticocaine Catalytic Antibodies have no Affinity for RTI Compounds: Implications for Treatment.  Synapse 41: 176-178, 2001.

233.         Kimmel, H.L., Joyce, A.R., Carroll, F.I., and Kuhar, M.J.  Dopamine D1 and D2 Receptors Influence Dopamine Transporter Synthesis and Degradation in the Rat.  J. Pharmacol. Exp. Ther. 298: 129-140, 2001.

234.         Kuhar, M.J. and Joyce, A.R.  Slow Onset of CNS Drugs: Can Changes in Protein Concentration Account for the Delay?  Trends Pharmacol. Sci. 22: 450-456, 2001.

235.         Stanley, S.A., Small, C.J., Murphy, K.G., Rayes, E., Abbott, C.R., Seal, L.J., Morgan, D.G.A., Sunter, D., Dakin, C.L., Kim, M.S., Hunter, R., Kuhar, M., Ghatei, M.A., and Bloom, S.R.  Actions of Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide on Regulation of Appetite and Hypothalamo-Pituitary Axes In Vitro and In Vivo in Male Rats.  Brain Res. 893: 186-194, 2001.

236.         Kimmel, H.L., Carroll, F.I., and Kuhar, M.J.  Locomotor Stimulant Effects of Novel Phenyltropanes in the Mouse.  Drug Alcohol Depend. 65: 25-36, 2001.

237.         Aja, S., Schwartz, G.J., Kuhar, M.J., and Moran T.H.  Intracerebroventricular CART Peptide Reduces Rat Ingestive Behavior and Alters Licking Microstructure.  Am. J. Physiol. Regul. Integr. Comp. Physiol. 280: R1613-R1619, 2001.

238.         Lakatos, A., Dominguez, G., and Kuhar, M.J.  CART Promoter CRE Site Binds Phosphorylated CREB.  Mol. Brain Res. 104: 81-85, 2002.

239.         Dominguez, G., Lakatos, A., and Kuhar, M.J.  Characterization of the Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Gene Promoter and Its Activation by a Cyclic AMP-Dependent Signaling Pathway in GH3 Cells.  J. Neurochem. 80: 885-893, 2002.

240.         Kimmel, H.L., Thim, L., and Kuhar, M.J.  Activity of Various CART Peptides in Changing Locomotor Activity in the Rat.  Neuropeptides 36: 9-12, 2002.

241.         Blough, B.E., Keverline, K.I., Nie, Z., Navarro, H., Kuhar, M.J., and Carroll, F.I.  Synthesis and Transporter Binding Properties of 3ß-[4’-(Phenylalkyl, -phenylalkenyl, and –phenylalkynl)-phenyl]tropane-2ß-carboxylic Acid Methyl Esters: Evidence of a Remote Phenyl Binding Domain on the Dopamine Transporter.  J. Med. Chem. 45: 4029-4037, 2002.

242.         Kimmel, H.L., Carroll, F.I., and Kuhar, M.J.  Withdrawal from Repeated Cocaine Alters Dopamine Transporter Protein Turnover in the Rat Striatum.  J. Pharmacol. Exp. Ther. 304: 15-21, 2003.

243.         Kuhar, M.J. and Joyce, A.R.  Is the Onset of Psychoactive Drug Effects Compatible with a Protein-Synthesis Mechanism?  Neuropsychopharmacology 28: 594-597, 2003.

244.         Damaj, M.I., Martin, B.R., and Kuhar, M.J.  Antinociceptive Effects of Supraspinal Rat Cart (55-102) Peptide in Mice.  Brain Res. 983: 233-236, 2003.

245.         Ekblad, E., Kuhar, M., Wierup, N., and Sundler, F.  Cocaine- and Amphetamine-Regulated Transcript: Distribution and Function in Rat Gastrointestinal Tract. Neurogastroenterol. Motil. 15: 545-557, 2003.

246.         Jaworski, J.N., Kozel, M.A., Philpot, K.B., and Kuhar M.J.  Intra-accumbal Injection of CART (Cocaine-Amphetamine Regulated Transcript) Peptide Reduces Cocaine-Induced Locomotor Activity.  J. Pharmacol. Exp. Ther. 307: 1038-1044, 2003.

247.         Wierup, N., Kuhar, M., Nilsson, B.O., Mulder, H., Ekblad, E., and Sundler, F.  Cocaine- and Amphetamine-Regulated Transcript (CART) is Expressed in Several Islet Cell Types during Rat Development.  J. Histochem. Cytochem. 52: 169-177, 2004.

248.         Kuriyama, G., Takekoshi, S., Tojo, K., Nakai, Y., Kuhar, M.J., and Osamura, R.Y. Cocaine- and amphetamine-regulated transcript peptide in the rat anterior pituitary gland is localized in gonadotrophs and suppresses prolactin secretion.  Endocrinology 145: 2542-2550, 2004.

249. Dominguez, G. and Kuhar, M.J.  Transcriptional Regulation of the CART Promoter in CATH.a Cells.  Mol. Brain Res. 126: 22-29, 2004.

250. Choi Y.H., Della-Fera, M.A., Li, C., Hartzell, D.L., Little, D.E., Kuhar, M.J., and Baile, CA. CART Peptide: Central Mediator of Leptin-Induced Adipose Tissue Apoptosis? Reg. Peptides 121: 155-162, 2004.

251. Damaj, M.I., Hunter, R.G., Martin, B.R., and Kuhar, M.J.  Intrathecal CART (55-102) Enhances the Spinal Analgesic Actions of Morphine in Mice.  Brain Res. 1024: 146-149, 2004.

252. Dominguez, G., del Giudice, E.M., and Kuhar, M.J.  CART Peptide Levels are Altered by a Mutation Associated with Obesity at Codon 34. Mol. Psychiatry 9: 1065-1066, 2004.

253.   Wierup, N., Richards, W.G., Bannon, A.W., Kuhar, M.J., Ahren, B., and Sundler, F.  CART Knock Out Mice have Impaired Insulin Secretion and Glucose Intolerance, Altered Beta Cell Morphology and Increased Body Weight.  Regul. Pept. 129: 203-211, 2005.

254.    Hunter, R.G., Vicentic, A., Rogge, G., and Kuhar, M.J.  The Effects of Cocaine on CART Expression in the Rat Nucleus Accumbens: A Possible Role for Corticosterone. Eur. J. Pharmacol. 517: 45-50, 2005.

255.     Vicentic, A., Lakatos, A., and Kuhar, M.J.  CART (Cocaine- and Amphetamine-Regulated Transcript) Peptide Receptors:  Specific Binding in AtT20 Cells.  Eur. J. Pharm. 528: 188-189, 2005.

256.     Carroll, F.I., Tyagi, S., Blough, B.E., Kuhar, M.J., and Navarro, H.A.  Synthesis and Monoamine Transporter Binding Properties of 3α-(Substituted phenyl)nortropane-2ß-carboxylic Acid Methyl Esters.  Norepinephrine Transporter Selective Compounds.  J. Med. Chem. 48: 3852-3857, 2005.

257. Hemby, S.E., Tang, W., Muly, E.C., Kuhar, M.J., Leonard L., and Mash, D.C.  Cocaine-Induced Alterations in Nucleus Accumbens Ionotropic Glutamate Receptor Subunits in Human and Non-Human Primates.  J. Neurochem. 95: 1785-1793, 2005.

258. Philpot, K.B., Dallvechia-Adams, S., Smith, Y., and Kuhar, M.J. A Cocaine-and Amphetamine-Regulated-Transcript Peptide Projection from the Lateral Hypothalamus to the Ventral Tegmental Area.  Neuroscience 135: 915-925, 2005.

259. Osei-Hyiaman, D., Depetrillo, M., Harvey-White, J., Bannan, A., Cravatt, B.F., Kuhar, M.J., Mackie, K., Palkovits, M., and Kunos, G. Cocaine- and Amphetamine-Related Transcript is Involved in the Orexigenic Effect of Endogenous Anandamine. Neuroendocrinology 81: 273-282, 2005.

260. Hunter, R.G., Lim, M.M., Philpot, K.B., Young, L.J., and Kuhar, M.J. Species Differences in Brain Distribu­tion of CART mRNA and CART Peptide between Prairie and Meadow Voles. Brain Res. 1048: 12-23, 2005.

261. Jaworski, J.N., Francis, D.D., Brommer, C.L., Morgan, E.T., and Kuhar, M.J.  Effects of Early Maternal Separation on Ethanol Intake, GABA Receptors and Metabolizing Enzymes in Adult Rats. Psychopharmacology (Berl.) 181: 8-15, 2005.

262. Wierup, N., Bjorkgvist, M., Kuhar, M.J., Mulder, H., and Sundler, F. CART Regulates Islet Hormone Secretion and Is Expressed in the β-Cells of Type 2 Diabetic Rats. Diabetes 55: 305-311, 2006.

263. Yanik, T., Dominguez, G., Kuhar, M.J., del Giudice, E.M., and Loh Y.P. The Leu34Phe ProCART Mutation Leads to Cocaine- and Amphetamine-Regulated Transcript (CART) Deficiency: A Possible Cause for Obesity in Humans. Endocrinology 147: 39-43, 2006.

264. del Giudice, EM, E., Santoro, N., Fiumani, P., Dominguez, G., Kuhar, M.J., and Perrone, L. Adolescents Carrying a Missense Mutation in the CART Gene Exhibit Increased Anxiety and Depression. Depress. Anxiety 23: 90-92, 2006.

265.      Joyce, A.R., Easterling, K., Holtzman, S.G., and Kuhar, M.J. Modeling the Onset of Drug Dependence: A Consideration of the Requirement for Protein Synthesis. J. Theor. Biol. 240: 531-537, 2006.

266.       Imad Damaj, M., Zheng, J., Martin, B.R., and Kuhar, M.J. Intrathecal CART (55-102) Attenuates Hyperalgesia and Allodynia in a Mouse Model of Neuropathic but not Inflammatory Pain. Peptides 27: 2019-2023, 2006.

267.     Vicentic, A., Francis, D., Moffett, M., Lakatos, A., Rogge, G., Hubert, G.W., Harley, J., and Kuhar, M.J. Maternal Separation Alters Serotonergic Transporter Densities and Serotonergic 1A Receptors in Rat Brain. Neuroscience 140: 355-365, 2006.

268.     Moffett, M.C., Harley, J., Francis, D., Sanghani, S.P., Davis, W.I., and Kuhar, M.J. Maternal Separation and Handling Affects Cocaine Self-administration in Both the Treated Pups as Adult and the Dams. J. Pharmacol. Exp. Ther. 317: 1210-1218, 2006.

269.     Hunter, R.G., Jones, D., Vicentic, A., Hue, G., Rye, D., and Kuhar, M.J. Regulation of CART mRNA in the Rat Nucleus Accumbens via D3 Dopamine Receptors. Neuropharmacology 50: 858-864, 2006.

270.     Moffett, M., Stanek, L., Harley, J., Rogge, G., Asnicar, M., Hsiung, H., and Kuhar, M.  Studies of Cocaine- and Amphetamine-Regulated Transcript (CART) Knockout Mice. Peptides 27: 2037-2045, 2006.

271.     Carroll, F.I., Fox B.S., Kuhar, M.J., Howard, J.L., Pollard, G.T., and Schenk, S.  Effects of Dopamine Transporter Selective 3-Phenyltropane Analogs on Locomotor Activity, Drug Discrimination, and Cocaine Self-administration after Oral Administration. Eur. J. Pharmacol.: 553(1-3): 149-156, 2006.

272.     Jones, DC and Kuhar, MJ. Cocaine-amphetamine-regulated transcript expression in the rat nucleus accumbens is regulated by adenylyl cyclase and the cyclic adenosine 5'-monophosphate/protein kinase a second messenger system.  J Pharmacol Exp Ther. 317(1):454-61., 2006.  PMID 16322355.

273.   Gunnarsdottir A, Wierup N, Larsson LT, Kuhar MJ, Ekblad E.  CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung’s disease.  Eur J Pediatr Surg 17:184-9, 2007.  PMID 17638157.

274.   Jones DC, Kuhar MJ.  CART receptor binding in primary cell cultures of the rat nucleus accumbens.  Synapse. Feb;62(2):122-7. 2008. PMID 18000808.

275.   van der Burg JM, Bacos K, Wood NI, Lindqvist A, Wierup N, Woodman B, Wamsteeker JI, Smith R, Deierborg T, Kuhar MJ, Bates GP, Mulder H, Erlanson-Albertsson C, Morton AJ, Brundin P, Petersén A, Björkqvist M.  Increased metabolism in the R6/2 mouse model of Huntington's disease.  Neurobiol Dis. Jan;29(1):41-51. 2008 PMID 17920283.

276.   Jaworski JN, Hansen ST, Kuhar MJ, Mark GP.  Injection of CART peptide into the nucleus accumbens reduces     cocaine self-administration in the rat.  Behav Brain Res 191:266-271, 2008.  PMID: 18485497.

277.   Francis DD and Kuhar MJ. Frequency of maternal licking and grooming correlates negatively with vulnerability to cocaine and alcohol use in rats.  Pharmacol Biochem Behav 90:497-500, 2008.  PMID: 18271022

278.   Hubert GW and Kuhar MJ.  Cocaine administration increases the fraction of CART cells in the rat nucleus accumbens that co-immunostain for c-Fos.  Neuropeptides 42:339-43, 2008.  PMID18314190.

279.     Bartell SM, Isales CM, Baile CA, Kuhar MJ, Hamrick MW.  CART deficiency increases body weight but does not alter bone strength.  J Musculoskelet Neuronal Interact 8:151-158, 2008.  PMID 18622083.

280.    Rogge GA, Jones DC, Green T, Nestler E, and Kuhar MJ.  Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo.  Brain Res 1251:42-52, 2009.  PMID 19046951.

281.   Jones DC, Lakatos A, Rogge GA, Kuhar MJ.  Regulation of CART mRNA expression by calcium-mediated signaling in GH3 cells.  Neuroscience. 160(2):339-347, 2009.  PMID 19258027

282.     Kuhar, MJ.  Measuring levels of proteins by various technologies: can we learn more by measuring turnover?  Biochem Pharmacol.  79(5):665-8, 2010.  PMID: 19814998

283.     Rogge GA, Shen LL, and Kuhar MJ.  Chromatin immunoprecipitation assays revealed CREB and serine 133 phospho-CREB binding to the CART gene proximal promoter.  Brain Res ­1344:1-12, 2010.  PMID:20451507

284.     Moffett MC, Song J, and Kuhar, MJ.  CART peptide inhibits locomotor activity induced by simultaneous stimulation of D1 and D2 receptors, but not by stimulation of individual dopamine receptors.  Synapse Jan; 65(1):1-7, 2011.  PMID:20506412. PMCID: PMC2939215.

285.     Lin Y, Hall RA, Kuhar MJ.  CART peptide stimulation of G protein-mediated signaling in differentiated PC12 Cells: Identification of PACAP 6-38 as a CART receptor antagonist.  Neuropeptides.  2011, 45:351-358.  PMID: 21855138. PMCID: PMC3170513.

286.     Brennan DJ, O'Connor DP, Laursen H, McGee SF, McCarthy S, Zagozdzon R, Rexhepaj E, Culhane AC, Martin FM, Duffy MJ, Landberg G, Ryden L, Hewitt SM, Kuhar MJ, Bernards R, Millikan RC, Crown JP, Jirström K, Gallagher WM. The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα and is an independent prognostic factor in node-negative breast cancer.  Oncogene. 2012 Jul 26;31(30):3483-94. doi: 10.1038/onc.2011.519. Epub 2011 Dec 5.  PMID: 22139072

287.     Balkan B, Keser A, Gozen O, Koylu EO, Dagci T, Kuhar MJ, Pogun S. Forced swim stress elicits region-specific changes in CART expression in the stress axis and stress regulatory brain areas.  Brain Res. 2012 Jan 13;1432:56-65. Epub 2011 Nov 9.  PMID: 22137563

288.   Balkan B, Gozen O, Koylu EO, Keser A, Kuhar MJ, Pogun S. Region- and sex-specific changes in CART mRNA in rat hypothalamic nuclei induced by forced swim stress. Brain Res. 2012 Oct 15;1479:62-71. PMID: 22960117.  PMCID: PMC3468742.

289.   Job MO and Kuhar MJ. Intraperitoneal Administration of CART-55-102 Inhibits Psychostimulant-Induced Locomotion. J Drug and Alcohol Res. 2012 January 1;1.  Doi:10.4303/jdar/235601. PMCID: PMC3659824

290.   Job MO, Shen LL, Kuhar MJ. The inhibition of cocaine-induced locomotor activity by CART 55-102 is lost after repeated cocaine administration. Neurosci Lett. 2013 Jun 29. doi:pii: S0304-3940(13)00586-7. 10.1016/j.neulet.2013.06.039. [Epub ahead of print]. PMID: 23819981.  PMCID: PMC3901563

291.   Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N. CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion. Diabetologia. 2016 Sep;59(9):1928-37. doi: 10.1007/s00125-016-4020-6. PMID:27338624

292.   Job MO. and Kuhar MJ. Cart Peptide in the Nucleus Accumbens Regulates Psychostimulants: Correlations Between Psychostimulant and Cart Peptide Effects.  Neuroscience. Online February 16, 2017. http://dx.doi.org/10.1016/j.neuroscience.2017.02.012.

293.    Kuhar MJ, and Job MO, CART Peptide Regulates Psychostimulant-Induced Activity and Exhibits a Rate Dependency (A commentary), Journal of Drug and Alcohol Research, 6 (2017), art236032. doi:10.4303/jdar/236032

Abstracts: While not listed here, the number of abstracts are about equal to the number of journal articles.

          SELECTED BOOK CHAPTERS, REVIEWS AND OTHER

          There are about 195 items in this category, but only selected ones are shown.

1.       Snyder, S.H., Kuhar, M.J., Green, A.I., Coyle, J.T., and Shaskan, E.G.  Uptake and Subcellular Localization of Neurotransmitters in the Brain.  Int. Rev. Neurobiol., Vol. 13, C.C. Pfeiffer and J.R. Smythies (Eds.), Academic Press, New York, pp. 127‑158, 1970.

2.       Aghajanian, G.K., Bunney, B.S., and Kuhar, M.J.  Use of Single Unit Recording in Correlating Transmitter Turnover with Impulse Flow in Monoamine Neurons.  In: New Concepts in Neurotransmitter Regulation, A.J. Mandel (Ed.).  Plenum Publ. Corp., New York, pp. 115‑134, 1973.

3.     Kuhar, M.J., Simon, J.R., and Rommelspacher, H.  Studies of Central Cholinergic Neurons.  In: Current Developments in Psychopharmacology, Vol. II, W.B. Essman and L. Valzelli (Eds.). Spectrum Publ., Inc., Holliswood, NY, pp. 3-27, 1975.

4.     Bird, S.J., Atweh, S.F., and Kuhar, M.J.  Microiontophoretic Study of the Effects of Opiates on Autoradio­graphically Localized Opiate Receptors.  In: Opiates and Opioid Peptides, H. Kosterlitz (Ed.). Elsevier/ North-Holland Biomedical Press, Amsterdam, pp. 199‑204, 1976.

5.     Pert, C.B., Snyder, S.H., and Kuhar, M.J.  Opiate Receptor Binding in Intact Animals.  In: Tissue Response to Addictive Drugs, D.H. Ford and D.H. Clouet (Eds.).  Spectrum Publ., Inc., Holliswood, New York, pp. 89‑101, 1976.

6.     Kuhar, M.J.  Autoradiographic Localization of Receptor Sites in the CNS in vivo.  In: Psycho­pharma­cology: A Generation of Progress, M.A. Lipton, A. DiMascio and K.F. Killam (Eds.). Raven Press, New York, pp. 371‑376, 1978.

7.     Kuhar, M.J.  Characteristics and Significance of Sodium‑Dependent, High Affinity Choline Uptake.  In: Cholinergic Mechanisms and Psychopharmacology, D. Jenden (Ed.).  Plenum Publ. Corp., New York,  pp. 447‑456, 1978.

8.     Kuhar, M.J. and Uhl, G.R.  Histochemical Localization of Opiate Receptors and the Enkephalins. In: Neuro­chemical Mechanisms of Opiate Action, D.H. Ross and H.H. Loh (Eds.).  Raven Press, New York, pp. 53‑68, 1978.

9.     Kuhar, M.J.  Histochemical Localization of Neurotransmitter Receptors.  In: Neurotransmitter Receptor Binding, H.I. Yamamura, S.J. Enna, and M.J. Kuhar (Eds.).  Raven Press, New York, pp. 113‑126, 1978.

10.   Young, W.S., III, and Kuhar, M.J.  Opiate Receptor Autoradiography: In vitro Labeling of Tissue Slices.  In: Characteristics and Function of Opioids, J.M. VanRee and L. Terenius (Eds.).  Elsevier/North Holland Biomedical Press, Amsterdam, pp. 451‑452, 1978.

11.    In: Centrally Acting Peptides, J. Hughes (Ed.).  University Park Press, Baltimore, pp. 85‑97, 1978.

12.   Murrin, L.C., Klemm, N. and Kuhar, M.J.  Autoradiographic Localization of Dopamine and Neuroleptic Receptors in the Rat Brain Using 3H‑Spiperone.  In: Catecholamines: Basic and Clinical Frontiers, E. Usdin, I. Kopin and J. Barchas (Eds.).  Pergamon Press, New York, pp. 598‑600, 1978.

13.   Young, W.S., III, and Kuhar, M.J.  Opioid Receptor Autoradiography in Brains of Humans and Animals.  In: Endogenous and Exogenous Opiate Agonists and Antagonists, E.L. Way (Ed.).  Pergamon Press, New York, pp. 131‑134, 1980.

14.     Kuhar MJ. The benzodiazepine receptor: anatomical aspects. NIDA Res Monogr. 1980;(33):12-21.  PMID:6275269

15.   Wamsley, J.K., Young, W.S., III, and Kuhar, M.J.  Anatomical Localization of Enkephalin Immuno­reactive Sites in Rat Forebrain.  In: Neural Peptides and Neuronal Communication, E. Costa and M. Trabucchi (Eds.). Raven Press, New York, pp. 257‑270, 1980.

16.   Palacios, J.M., Young, W.S., III, and Kuhar, M.J.  GABA and Benzodiazepine Receptors in Rat and Human Brain: Autoradiographic Localization by a Novel Technique.  In: Enzymes and Neurotransmitters in Mental Disease, E. Usdin, T.L. Sourkes and M.B.H. Youdin (Eds.).  John Wiley and Sons, New York, pp. 573‑583, 1980.

17.   Palacios, J.M., Wamsley, J.K., Zarbin, M.A., and Kuhar, M.J.  GABA and Glycine Receptors in Rat Brain: Autoradiographic Localization.  In: Amino Acid Neurotransmitters, F.V. DeFeudis and P. Mandel (Eds.). Adv. Biochem. Psychopharm. Vol. 29, (E. Costa and P. Greengard, Series Eds.). Raven Press, New York, pp. 445‑451, 1981.

18.   Wamsley, J.K., Zarbin, M.A., Birdsall, N.J.M., and Kuhar, M.J.  Muscarinic Cholinergic Receptor Localization by Radiohistochemistry.  In: Cholinergic Mechanisms, G. Pepeu and H. Ladinsky (Eds.).  Adv. Behav. Biol. 25.  Plenum Press, New York, pp. 587‑595, 1981.

19.   Kuhar, M.J.  The Benzodiazepine Receptor: Anatomical Aspects. In: Benzodiazepines: A Review of Research Results, 1980, (NIDA Research Monograph Series 33), S.I. Szara and J.P. Ludford (Eds.). U.S. Government Printing Office, Washington, DC, pp. 12‑21, 1981.

20.   Young, W.S., III, and Kuhar, M.J.  The Light Microscopic Radiohistochemistry of Drug and Neurotrans­mitter Receptors Using Diffusible Ligands.   In: Current Trends in Morphological Techniques, Vol. III, J.E. Johnson, Jr. (Ed.).  CRC Press, Boca Raton, FL, pp. 119‑135, 1981.

21.   Kuhar, M.J.  Localization of Drug and Neurotransmitter Receptors in Brain by Light Microscopic Auto­radiography.  In: The Handbook of Psychopharmacology, Vol. 15, S.D. Iversen, L.L. Iversen and S.H. Snyder (Eds.).  Plenum Publ. Co., New York, pp. 299‑320, 1982.

22.   Kuhar, M.J.  Opioid Receptors and Peptides in Pain Control.  In: Diagnosis and Treatment of Chronic Pain, N.H. Hendler, D.M. Long and T.N. Wise (Eds.). Johns Wright Publishing, Inc., Boston, pp. 193‑199, 1982.

23.   Kuhar, M.J.  Radiohistochemical Localization of Benzodiazepine Receptors.  In: Pharmacology of Benzo­diazepines, E. Usdin, P. Skolnick, J.F. Tallman, Jr., D. Greenblatt, and S.M. Paul (Eds.).  Macmillan Press, New York, pp. 149‑154, 1982.

24.   Pögün, S., Duelfer, T., Corley, E.G., Dannals, R.F., Dranbauer, B.J., Scheffel, U., Waud, J.M., O'Brien, H.A., Kuhar, M.J., Burns, H.D., and Wagner, H.N., Jr.  Radiolabeled Spiperone Analogues for Imaging Dopamine Receptors.  In: Nuclear Medicine and Biology Advances. Proceedings of the Third World Congress of Nuclear Medicine and Biology, Vol. IV, C. Raynaud (Ed.).  Pergamon Press, Paris, pp. 3606‑3609, 1982.

25.   Kuhar, M.J.  Autoradiographic Localization of Drug and Neurotransmitter Receptors.  In: Methods in Chemical Neuroanatomy; Vol. 1, Handbook of Chemical Neuroanatomy, A. Björklund and T. Hökfelt (Eds.). Elsevier, Amsterdam, pp. 398‑415, 1983.

26.   Wagner, H.M., Jr., Burns, H.D., Dannals, R.F., Wong, D.F., Langstrom, B., Duelfer, T., Frost, J.J., Ravert, H.T., Links, J.M., Rosenbloom, S., Lukas, S.E., Kramer, A.V., and Kuhar, M.J.  Assessment of Dopamine Receptor Activity in the Human Brain with Carbon‑11 N‑Methylspiperone.  In: Proceed­ings from the Third Symposium on the Medical Application of Cyclotrons, Turku, Finland, June 13‑16, 1983.  Ann. Univ. Turkvensis D 17: 263‑268, 1984.

27.   Wagner, H.N., Burns, H.D., Dannals, R.F., Wong, D.F., Langstrom, B., Duelfer, T., Frost, J.J., Ravert, H.T., Links, J.M., Rosenbloom, S., Lukas, S.E., Kramer, A.V., and Kuhar, M.J.  In: The Metabolism of the Human Brain Studied with Positron Emission Tomography, T. Greitz et al. (Eds.).  Raven Press, New York, pp. 251‑267, 1985.

28.   Freed, W.J., Olson, L., Ko, G.N., Morihisa, J.M., Niehoff, D., Stromberg, I., Kuhar, M.J., Hoffer, B.J., and Wyatt, R.J.  Intraventricular Substantia Nigra and Adrenal Medulla Grafts: Mechanisms of Action and [3H]Spiroperidol Autoradiography.  In: Neural Grafting in the Mammalian CNS, A. Bjorklund and U. Stenevi (Eds.).  Elsevier Science Publishers, New York, pp. 471‑489, 1985.

29.   Kuhar, M.J., Unnerstall, J.R., and De Souza, E.B.  Receptor Mapping in Neuropharmacology by Auto­radiography: Some Technical Problems.  NIDA Research Monograph 62: 1‑12, 1985.

30.   Whitehouse, P.J., Loats, H.L., Price, D.L., Lloyd, D.G., Kuhar, M.J., and Altschuler, R.J.  New Approaches in Quantitative Neuropathology.  In: Biological Psychiatry, C. Shagass et al. (Eds.). Elsevier Science Publishing Co., New York, pp. 1385‑1387, 1986.

31.   Wagner, H.N., Jr., Dannals, R.F., Frost, J.J., Wong, D.F., Ravert, H.T., Wilson, A.A., Links, J.M., Burns, H.D., Kuhar, M.J., and Snyder, S.H.  Imaging Dopamine and Opiate Receptors in the Human Brain in Health and Disease.  In: Biomedical Imaging, O. Hayaishi (Ed.).  Academic Press, New York, pp. 285‑296, 1986.

32.   Kuhar, M.J.  Human Brain Mapping.  In: Molecular Biology of the Human Brain, E.G. Jones (Ed.). Alan R. Liss, New York, pp. 185-190, 1988.

33.   Kuhar, M.J., Ritz, M.C., and Sharkey, J.  Cocaine Receptors on Dopamine Transporters Mediate Cocaine-Reinforced Behavior.  In: Mechanisms of Cocaine Abuse and Toxicity (NIDA Research Monograph Series 88), D. Clouet, K. Asglan and R. Brown (Eds.).  U.S. Government Printing Office, Washington, DC, pp. 14‑22, 1988.

34.   Wong, D.F. and Kuhar, M.J.  In vivo PET and SPECT Receptor Imaging: New Technology and Tactics for Receptor Measurement.  In: Neuroreceptors and Signal Transduction, S. Kito, T. Segawa, K. Kuriyama, M. Tohyama and R.W. Olsen (Eds.).  Plenum Press, New York, pp. 181‑193, 1988.

35.   Wagner, H.N., Weinberger, D.R., Kleinman, J.E., Casanova, M.F., Gibbs, C.J., Gur, R.E., Hornykiewicz, O., Kuhar, M.J., Pettegrew, J.W., and Seeman, P.  Scientific Directions: A Plan for Research on Schizo­phrenia.  Neuroimaging and Neuropathology Panel.  A National Plan for Schizo­phrenia Research:  Report of the National Advisory Mental Health Council.  DHHS Publication No. (ADM) 88‑1571, pp. 19‑22, 1988.

36.   Kuhar, M.J. and De Souza, E.B.  Autoradiographic Imaging: Localization of Binding Sites Other Than Neurotransmitter Receptors.  In: Visualizations of Brain Functions, D. Ottoson and W. Rostene (Eds.). Stockton Press, New York, pp. 57‑66, 1989.

37.   Kuhar, M.J.  Perspectives.  In: Brain Imaging Techniques and Applications, N.A. Sharif and M.E. Lewis (Eds.).  John Wiley & Sons, New York, pp. 13‑17, 1989.

38.   Kuhar, M.J.  Introduction to Neurotransmitters and Neuroreceptors.  In: Quantitative Imaging: Neuro­receptors, Neurotransmitters, and Enzymes, J.J. Frost and H.W. Wagner, Jr. (Eds.).  Raven Press, New York, pp. 1‑7, 1990.

39.   Carroll, F.I., Rahman, M.A., Philip, A., Lewin, A.H., Boja, J.W., and Kuhar, M.J.  Synthesis and Receptor Binding of Cocaine Analogs.  In: Problems of Drug Dependence 1990: Proceeding of the 52nd Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc. (NIDA Research Monograph Series 105), L.S. Harris (Ed.).  U.S. Government Printing Office, Washington, DC, pp. 147‑153, 1991.

40.   Kuhar, M.J., Ritz, M.C., Grigoriadis, D., Lew, R., and Sharkey, J.  A Cocaine Receptor Associated with Dopamine Transport and Drug Self-administration.  In: Cocaine Pharmacology, Physiology and Clinical Strategies, J.M. Lakoski, M.P. Galloway and F.J. White (Eds.). CRC Press, Boca Raton, pp. 191-202, 1992.

41.   Kuhar, M.J. and DeSouza, E.B.  Receptor Autoradiography as an Aid in Explaining Drug Action.  In: Imaging

Drug Action in the Brain, E.D. London (Ed.).  CRC Press, Boca Raton, pp. 49-60, 1993.

42.   Scheffel, U., Dannals, R.F., Suehiro, M., Ricaurte, G.A., Carroll, F.I., Kuhar, M.J., and Wagner, H.N., Jr.  Development of PET/SPECT Ligands for the Serotonin Transporter.  NIDA Res. Monogr. 138: 111-130, 1994.

43.   Kuhar, M.J.  Discussion.  In: Sites of Drug Action in the Human Brain, A. Beigon and N.D. Volkow (Eds.). CRC Press, Boca Raton, pp. 173-178, 1995.

44.   Kuhar, M.J.  In vitro Labeling Autoradiography: Development and Perspectives.  In: Auto­radiography and Correlative Imaging, W.E. Stumpf and H.F. Solomon (Eds.).  Academic Press, San Diego, pp. 203-219, 1995.

45.   Zarbin, M.A., Unnerstall, J.R., and Kuhar, M.J.  Axonal Transport of Receptors: Emphasis on a2-Adrenic Binding Sites.  In: Autoradiography and Correlative Imaging, W.E. Stumpf and H.F. Solomon (Eds.).  Academic Press, San Diego, pp. 309-320, 1995.

46.   Kuhar, M.J. and Schuster, C.R.  Integrative Neurobehavioral Pharmacology: Focus on Cocaine.  In:  Pharmacological Aspects of Drug Dependence: Toward an Integrated Neurobehavioral Approach, Vol. 118, Handbook of Experimental Pharmacology, C.R. Schuster and M.J. Kuhar (Eds.).  Springer-Verlag, New York, pp. 53-80, 1996.

47.   Carroll, F.I., Lewin, A.H. and Kuhar, M.J.  Chapter 9: Dopamine Transporter Uptake Blockers.  In: Neurotransmitter Transporters: Structure, Function and Regulation, M.E.A. Reith (Ed.).  Humana Press, Clifton, NJ, pp. 263-295, 1997.

48.   Kuhar, M.J., Carroll, F.I., Lewin, A.H., Boja, J.W., Scheffel, U., and Wong, D.F.  Imaging Trans­porters for Dopamine and Other Neurotransmitters in Brain.  In: Neurotransmitter Trans­porter: Struc­ture, Function, and Regulation, M.E.A. Reith (Ed.).  Humana Press, Clifton, NJ, pp. 297-313, 1997.

49.   Patel, A.P., Carroll, F.I., and Kuhar, M.J.  Turnover of Rat Dopamine Transporter Protein in rDAT-LLC-PK1 Cells.  In:  Neurotransmitter Release and Uptake, S. Pögün (Ed.).  Springer-Verlag, Berlin/ Heidelberg, pp. 231-236, 1997.

50.   Wong, D.F., Ricaurte, G., Gründer, G., Rothman, R., Naidu, S., Singer, H., Harris, J., Yokoi, F., Villemagne, V., Szymanski, S., Gjedde, A., and Kuhar, M.  Dopamine Transporter Changes in Neuropsychiatric Disorders.  In: Catecholamines: Bridging Basic Science with Clinical Medicine, D.S. Goldstein, G. Eisenhofer, and R. McCarty (Eds.).  Academic Press, San Diego, pp. 219-222, 1998.

51.   Vaughan, R.A., Huff, R.A., Uhl, G.R., and Kuhar, M.J.  Phosphorylation of Dopamine Transporters and Rapid Adaptation to Cocaine.  In: Catecholamines: Bridging Basic Science with Clinical Medicine, D.S. Goldstein, G. Eisenhofer, and R. McCarty (Eds.).  Academic Press, San Diego, pp. 1042-, 1998.

52.   Kuhar, M.J.  Addiction.  In: The Dana Brain Science Guide: Resources of Secondary and Post-Secondary Teachers and Students.  The Dana Press, New York, pp. 47-48, 1999.

53.   Dallvechia-Adams, S., and Kuhar, M.J.  CART (CART Peptides).  In: Wiley Encyclopedia of Molecular Medicine.  John Wiley & Sons, New York, pp. 479-481, 2002.

54.   Kuhar, M.J., Minneman, K., and Muly, E.C. Catecholamines.  In: Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 7th Edition, G.J. Siegel, R.W. Albers, S.T. Brady and D.L. Price (Eds.). Elsevier Academic Press: Burlington, MA, pp. 211-225, 2006.

141.   Philpot, K.B. and Kuhar, M.J.  CART Peptide and Ingestive Behavior. In: Handbook of Biologically Active Peptides, A.J. Kastin (Ed.). Elsevier Academic Press: Burlington, MA, pp. 913-918, 2006.

142.   Kuhar, M.J.  Why Just Saying No Is Not Enough.  In: 2007 Advances in Brain Research, B. Rich (Ed.). Dana Foundation Press, pp. 11-12, 2007.

143.   Kuhar, M.J.  Introduction of the Nathan B. Eddy Recipient.  NIDA Research Monograph Series No. 187.  Problems of Drug Dependence, 2006: Proceedings of the 68th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc., pp 69-70, 2007.

144.    Carroll FI, Howard, JL, Howell LL, Fox BS, Kuhar MJ.  Development of the Dopamine Transporter selective RTI-336 as a Pharmacotherapy for cocaine abuse.  In: Drug Addiction: from basic research to therapy, Rapaka RS and Sadee W (Eds).  Springer, pp 1179-192, 2008.

STUDENTS, FELLOWS AND VISITORS

     More than seventy pre- and postdoctoral students, visitors and other trainees have spent time training in Dr Kuhar’s laboratory in research. Many went on to important positions in academia, industry, and government. A detailed list is availble on request.

TEACHING AND RELATED CONTRIBUTIONS (January 1995 to June 2022 at Emory University)

Dr Kuhar has been involved in teaching and training: graduate students in the Neuroscience Program and in the Molecular and Systems Pharmacology Program, medical students in the psychiatry and pharmacology courses, post-doctoral fellows and PGY IV residents in the Addictions Psychiatry Program.  He also gives lectures in eight courses in various programs. (Note that in addition to this teaching and mentoring at Emory, He did similar work in the Depts of Pharmacology and Neuroscience at The Johns Hopkins University School of Medicine from 1972 to 1985 as faculty, and then from 1985 to 1995 as an Adjunct.)

Molecular and Systems Pharmacology Graduate Program:

1.     Executive Committee for 3 years.

2.     Director of student qualifying exams, 2 years.

3.     Director of IBS 531, the main Pharmacology course for incoming graduate students, for 3 years.

4.     Lectures in IBS 531, 532, 506Y, 717, 501, 570R

5.     Course Director for IBS 717, Neuropharmacology, and course Director for MSP501 Ethics.

6.     Involvement in new student interviewing and recruiting.

7.     Since 1995, mentored about 30 trainees.

8.     Thesis committees for 15 students.

Neuroscience Graduate Program:

1.     Mentored rotation students, about 2 per year.

2.     Chair of Nominating Committee for new program directors and committee members, for 6 years.

3.     Thesis committees.

4.     Involvement in new student interviewing and recruiting.

5.     Course Director for Frontiers in Neuroscience, a required seminar course for 2 years.

6.     Course C0-Director for NS570 and IBS717.

7.     Lectures in Systems Neuroscience Course and in Frontiers of Neuroscience Series.

8.     Executive Committee, 3 years.

Medical Students:

1.     Lectures on antidepressant, antipsychotic and Alzheimer’s drugs in the Pharmacology Course.

2.     Lectures on psychostimulants in the Behavioral Neuroscience and Psychiatry Course.

3.     Lectures on Pharmacokinetics in Module 1.

PGY IV Addictions Psychiatry Program:

1.     Advisor to Program Director since inception of the program.

2.     Lectures on general drug abuse, psychostimulants, buprenorphine and drug development to residents and Fellows in Addiction Psychiatry.

Postdoctoral Fellows:

1.     Mentor to 20 fellows.

Other:

1. In the role of Senior Scientist and Chief of the Neuroscience Division at Yerkes, I both formally and informally mentored young faculty as well as students and fellows.

2. Lectures in Grants Workshop for Emory faculty and fellows and students.

3. Director of the Institutional NIDA Training Program (2003 – 2014), “The Neurobiology of Drug Abuse”, which provided 10 training slots to our training faculty per year.

4.     Ethics lectures on Authorship, Research Misconduct, Mentoring, Data Management and Collegial Ethics

5.     Lectures to Tibetan monks in the ETSI program in India, 3 consecutive summers (2008-11), on drug Addiction.

6.     Lectures on drug addiction to Anesthesiology Associates and in IBS532, NS570, IBS506, MSP501, and IBS717. Also, discussion leader on Research Misconduct in GAH601.

7.     Development and presentation of a MOOC with Emory and Coursera: “The Addicted Brain”

8.     Numerous lectures on ethics and addiction to the community in various forums or courses.

9.     Mentor to trainee in the Center for Ethics.

10.   Various lectures on ethical topics in a variety of meetings and forums.

Grant Support

     In addition to university funds and salary, Dr Kuhar’s research and teaching has been supported by grant funds; these amounted to more than 38 million dollars. 

The federal sources of these grants include the National Institute of Mental Health, the National Institute on Drug Abuse, The National Institute of General Medical Sciences, The National Institute of Neurologic Disorders and Stroke, and The Office of National Drug Control Policy,

State sources include the Georgia Research Alliance.

Private and industry sources include Pfizer, Hoffman-La Roche, Lederle, Upjohn, Solvay, the Mcknight Foundation, and the Huntington’s Disease Fund.

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