Michael Bottery

I am a Wellcome-funded research fellow within the Manchester Fungal Infection Group at the University of Manchester. I am an evolutionary microbiologist focused on understanding the ecological and evolutionary selective drivers of antimicrobial resistance (AMR) in fungal and bacterial pathogens. My work aims to explore how the genomic context of a pathogen interacts with its environment to alter the evolution and spread of AMR within microbial populations. My current work focuses on the evolution of AMR within the human fungal pathogen Aspergillus fumigatus: how resistance arises within individuals and populations, the molecular mechanisms of resistance, and the environmental selective drivers of resistance. I use a combination of mathematical and computational modelling, experimental evolution, and molecular microbiology to investigate the selective dynamics and trajectories of AMR evolution.