Molecular and Integrative Biology Laboratory
“Where Molecular Discoveries Drive Translational Medicine.”
Our Vision, Goals, and Research Focus
“We strive, driven by curiosity, to provide one of the keys to unlocking new paradigms in aging and regeneration for humanity.”
Discover key pathways of muscle, mitochondrial, and metabolic homeostasis in aging
Identify culprit biomarkers and therapeutic targets in muscle, mitochondrial, and metabolic homeostasis
Develop novel therapeutic options promoting healthy aging and slowing aging
Elucidate how skeletal muscle mediates the positive systemic effects of exercise
Discover and characterize mitokines, exerkines, and myokines with physiological and pathological significance
Translate novel interventions such as NAD⁺ boosters, myokines, and natural compounds including microbiota-derived metabolites
Foster global collaborations across academia, hospitals, and industry
Train the next generation of biomedical scientists and engineers
Aging and Muscle Biology
Mitochondrial dynamics and energy metabolism
Myokines, mitokines, and exerkines as systemic signaling factors
NAD⁺ metabolism and interventions
Multi-omics and translational disease models
Dongryeol Ryu, Ph.D.
Associate Professor
Department of Biomedical Science and Engineering (BMSE)
Gwangju Institute of Science and Technology (GIST)
Dongryeol Ryu, Ph.D., is an Associate Professor at GIST, where he leads the Molecular and Integrative Biology (MIB) Laboratory. He earned his Ph.D. in Molecular Cell Biology from Sungkyunkwan University (SKKU) School of Medicine under Prof. Seung-Hoi Koo and completed his postdoctoral training with Prof. Johan Auwerx at the Swiss Federal Institute of Technology Lausanne (EPFL). Before joining GIST, he held faculty positions at Sungkyunkwan University and Pusan National University.
He currently serves as the principal investigator of the “Consortium for Multimodal Sarcopenia Therapeutics (2024–2028)” under Korea’s ARPA-H program (HAPPY : Holistic Approach for Promoting Physical Youthfulness), leading a nationwide effort to develop next-generation therapeutic strategies for sarcopenia.
“Where Molecular Discoveries
Drive Therapeutic Innovation.”
“Exploring the Biology of Aging, Metabolism,
and Muscle for Healthier Lifespan.”
Prof. Ryu’s research focuses on aging biology, metabolism, muscle biology, and mitochondrial homeostasis, aiming to uncover molecular mechanisms and therapeutic strategies that promote healthy aging. His recent work highlights small metabolites and integrative biological approaches that enhance mitochondrial function and delay age-related decline.
He has authored over 150 peer-reviewed publications with more than 16,000 citations. His scientific impact has been recognized internationally, being named a Clarivate Highly Cited Researcher (Top 1%) in 2022 and ranked among the world’s top 2% of scientists by Stanford University and Elsevier from 2022 to 2025.
Through these efforts, Prof. Ryu and the MIB Lab strive to advance the understanding of molecular signaling pathways in aging and metabolism, while also training the next generation of scientists in biomedical research. (As of March. 2026)
Meet the Team
Shibo Wei, M.D., Ph.D.
Postdoctoral Research Fellow | Cardiothoracic Surgeon & Physician-Scientist pursuing diverse regenerative medicine projects
Yan Zhang, M.D., Ph.D.
Postdoctoral Research Fellow | Endocrinologist & Physician-Scientist conducting projects on NAD⁺ metabolism
EunJu Jin, Ph.D.
Postdoctoral Research Fellow | Developing novel technologies for muscle regeneration
Wonyoung Park, T.M.D., Ph.D.
Postdoctoral Research Fellow | Studying metabolic regulation of epigenetic reprogramming
Thanh T. Nguyen, M.D.
Ph.D. Candidate | Endocrinologist researching therapeutic development for muscle aging and novel roles of exercise
Tam Dao, M.D.
Ph.D. Candidate | Studying aging through multi-omics analyses using bioinformatics approaches
Yingqi Xue, M.D.
Ph.D. Student | Developing novel approaches to promote healthy aging using
C. elegans
Sei Kim, B.A.
Ph.D. Student | Investigating mechanisms of muscle aging and muscle memory
Suenjun Jeong, B.A.
Integrated M.S.–Ph.D. Student | Researching aging and regeneration of muscle and connective tissue
Hạnh Minh, B.A.
Integrated M.S.–Ph.D. Student | Investigating novel myokines regulating hormesis and resilience
Ms. Soyoung Jeong
Administrative Support
Lab Alumni
Assistant Professor
Wonkwang University
School of Medicine
Assistant Professor
Konkuk University
College of Medicine
Minjeong Kim, MS
Heejung Choi, BS
Jin-Mo Koo, KMD
Hea-Ju Kim, KMD
Jeong Ho Kwon, PhD
Yuna Kim, PhD
Baeki E. Kang, PhD
Junhyeon Park, MS
Junho Choi, MD candidagte
Younghyun Choi, KMD candi.
Recent Featured Papers
Lab News
Prof. Dongryeol Ryu has been continuously listed among the World’s Top 2% Scientists (Stanford University & Elsevier, 2022–2025).
Oct, 2025
Congratulations on
your professorship!
교수임용 축하드려요!
C11 4F 회의실
August, 2025
켄싱턴리조트 지리산하동
August, 2025
Moments at the MIB Lab
The 2025 KSBMB International Symposium
사석상 수상 (Sasuk Award)