Investigating regeneration through genetics

and single-cell analysis

Melanie I. Worley, Ph.D.

mworley@berkeley.edu

UC Berkeley, Hariharan Lab

  • How do tissues effectively regulate and coordinate regeneration?

  • To uncover the molecular and cellular mechanisms that regulate regenerative growth and repatterning.

  • I am combining genetics, developmental biology, and single-cell analysis.

Ongoing Work: Single-cell analysis + regeneration!


Critical genetic program for Drosophila imaginal disc regeneration revealed by single-cell analysis | Melanie I. Worley, Nicholas J. Everetts, Riku Yasutoi, Nir Yosef, and Iswar K.Hariharan


Nicholas J. Everetts*, Melanie I. Worley*, Riku Yasutomi, Nir Yosef, and Iswar K. Hariharan *co-first authors

The transcriptional co-repressor CtBP is a negative regulator of growth that antagonizes the Yorkie and JNK/AP-1 pathways

Taryn M. Sumabat, Melanie I. Worley, Brett J. Pellock, Justin A. Bosch, Iswar K. Hariharan


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Rachel Smith-Bolton, Melanie I. Worley, Hiroshi Kanda, Iswar K. Hariharan

<Dev Cell link> <Dev Cell Preview>