Investigating regeneration through genetics

and single-cell analysis

Melanie I. Worley, Ph.D.

mworley@berkeley.edu

UC Berkeley, Hariharan Lab

  • How do tissues effectively regulate and coordinate regeneration?

  • To uncover the molecular and cellular mechanisms that regulate regenerative growth and repatterning.

  • I am combining genetics, developmental biology, and single-cell analysis.

Ets21C sustains a pro-regenerative transcriptional program in blastema cells of Drosophila imaginal discs | Current Biology

Melanie I. Worley*, Nicholas J. Everetts*, Riku Yasutoi, Rebecca J. Chang, Shrey Saretha, Nir Yosef, and Iswar K.Hariharan

<Current Biology link>

Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions | eLife


Nicholas J. Everetts*, Melanie I. Worley*, Riku Yasutomi, Nir Yosef, and Iswar K. Hariharan *co-first authors

<eLife link> <GitHub> <GEO Data>

The transcriptional co-repressor CtBP is a negative regulator of growth that antagonizes the Yorkie and JNK/AP-1 pathways

Taryn M. Sumabat, Melanie I. Worley, Brett J. Pellock, Justin A. Bosch, Iswar K. Hariharan


<link>

Regeneration and Transdetermination in Drosophila Imaginal Discs | Annual Reviews Genetics


Melanie I. Worley, Linda Setiawan, and Iswar K. Hariharan

<Review link>

Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc | Dev Cell

Rachel Smith-Bolton, Melanie I. Worley, Hiroshi Kanda, Iswar K. Hariharan

<Dev Cell link> <Dev Cell Preview>