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Pharmacologic Category
Dosing: Adult
Protectant: Topical: Apply as required to affected areas several times daily
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Note: Approved uses and ages for pediatric patients may vary by product; consult product specific labeling.
Skin protectant: Infants, Children, and Adolescents: Topical:
Cream, ointment, paste, stick: Apply generously to affected area as needed, especially with each diaper change or after incontinence episodes
Powder: Apply as needed
Use: Labeled Indications
Protective coating for mild skin irritations and abrasions; soothing and protective ointment to promote healing of chapped skin, diaper rash
Administration: Pediatric
Topical:
Cream, paste, stick: For external use only; do not use in the eyes. Gently cleanse affected area and pat dry with a clean soft cloth or allow to air dry. May use dry tissue to remove excess product.
Powder: For external use only; avoid contact with eyes and face or mouth (to avoid breathing in powder). Do not use on broken skin.
Storage/Stability
Avoid prolonged storage at temperatures >30°C.
Medication Patient Education with HCAHPS Considerations
What is this drug used for?
• It is used to treat or prevent diaper rash.
• It is used to treat skin irritation.
• It is used to treat poison oak, ivy, and sumac rashes.
Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:
• A significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.
Contraindications
Hypersensitivity to zinc oxide or any component of the formulation
Pregnancy Considerations
Zinc oxide is not expected to be absorbed systemically following topical administration to healthy skin (Newman, 2009). Systemic absorption would be required in order for zinc oxide to cross the placenta and reach the fetus.
Adverse Reactions
1% to 10%:
Hypersensitivity: Local hypersensitivity reaction
Local: Local irritation
Metabolism/Transport Effects
None known.
Drug Interactions Open Interactions
There are no known significant interactions.
Dosage Forms: US
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Aerosol, topical:
Dr. Smith's Diaper Rash: 10% (100 g) [contains methylparaben, polysorbate 80, propylene glycol, and propylparaben]
Dr. Smith's Adult Barrier: 10% (170 g) [contains methylparaben, polysorbate 80, propylene glycol, and propylparaben]
Cream, topical:
Balmex: 11.3% (60 g, 120 g, 480 g) [contains aloe, benzoic acid, soybean oil, and vitamin E]
Desitin Rapid Relief: 13% (57 g, 113 g)
Elta Seal Moisture Barrier: 6% (114 g [DSC])
Cream, topical [stick]:
Balmex: 11.3% (56 g) [contains aloe, benzoic acid, soybean oil, and vitamin E]
Ointment, topical:
AmeriDerm PeriShield: 3.8% (100 g)
Boudreaux's Butt Paste: 16% (10 g, 28 g, 57 g, 113 g, 454 g)
CareAll: 20% (28 g, 56 g, 425 g)
Dr. Smith's Diaper Rash: 10% (57 g, 85 g, 227 g)
PeriGuard: 3.8% (100 g)
Pharmabase Barrier: 9.38% (500 g)
Generic: 20% (30 g, 60 g, 454 g); 40% (120 g)
Paste, topical:
Calazime Skin Protectant: 16.5% (113 g [DSC]) [contains calamine, menthol]
Critic-Aid Thick Moist Barrier: 20% (71 g, 170 g) [DSC]
Desitin Maximum Strength Original: 40% (28 g, 57 g, 85 g, 120 g, 113 g, 454 g) [contains cod liver oil and lanolin]
Triple Paste: 12.8% (57 g, 454 g, 227 g)
Powder, topical:
Ammens® Original Medicated: 9.1% (312 g)
Ammens® Shower Fresh: 9.1% (312 g)
Generic Available (US)
Yes: Ointment
Pricing: US
Aerosol (Dr Smiths Adult Barrier External)
10% (per gram): $0.10
Aerosol (Dr Smiths Diaper Rash External)
10% (per gram): $0.08
Cream (Secura Protective External)
10% (per gram): $0.18
Ointment (AmeriDerm PeriShield External)
3.8% (per gram): $0.02
Ointment (Boudreauxs Butt Paste External)
16% (per gram): $0.07
40% (per gram): $0.07
Ointment (Dr Smiths Adult Barrier External)
10% (per gram): $0.08
Ointment (Dr Smiths Diaper External)
10% (per gram): $0.08
Ointment (Pharmabase Barrier External)
9.38% (per gram): $2.60
Ointment (Triple Paste External)
12.8% (per gram): $0.12
Ointment (Zinc Oxide External)
20% (per gram): $0.02 - $0.16
Paste (Zinc Oxide External)
25% (per gram): $0.14
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Mechanism of Action
Mild astringent with weak antiseptic properties
Local Anesthetic/Vasoconstrictor Precautions
No information available to require special precautions
Effects on Dental Treatment
No significant effects or complications reported
Effects on Bleeding
No information available to require special precautions
Index Terms
Base Ointment; Lassar's Zinc Paste
References
Adam R, "Skin Care of the Diaper Area," Pediatr Dermatol, 2008, 25(4):427-33.[PubMed 18789081]
Ammens Medicated Powder Original (zinc oxide) [prescribing information]. El Paso, TX: Idelle Labs, Ltd.; May 2013.
Balmex Adult Care Rash (zinc oxide) [prescribing information]. Chattanooga, TN: Chattem, Inc.; April 2013.
Balmex Diaper Rash Stick (zinc oxide) [prescribing information]. Chattanooga, TN: Chattem, Inc.; January 2010.
Desitin Maximum Strength Original (zinc oxide) [prescribing information]. Skillman, NJ: Johnson & Johnson Consumer Products Company; November 2015.
Newman MD, Stotland M, and Ellis JI, "The Safety of Nanosized Particles in Titanium Dioxide- and Zinc Oxide-Based Sunscreens," J Am Acad Dermatol, 2009, 61(4):685-92.[PubMed 19646780]
Periguard (zinc oxide) [prescribing information]. North Bergen, NJ: DermaRite Industries LLC; November 2014.
Visscher MO, "Update on the Use of Topical Agents in Neonates," Newborn & Infant Nursing Reviews, 2009, 9(1):33362-80.
Brand Names: International
Baby Rash Free (EG); Curash (AU, NZ, PH); De-Rash (LK); Desitin (MX); Double-Care (EG); Mixtura Alba (CZ); Napi-Care (EG); Pasta de Lassar (MX); Pasta Zinci (PL); Rashfree (PH); Unguentum Zinci Oxydati (PL); Zinxyderm (BE)
Last Updated 3/25/20
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